OBJECTIVE To investigate pathogenetic condition and fungal detection on evaluating acute exacerbation of COPD(AECOPD),and the relation of the severity and risk of death during hospital stay.METHODS Samples of sputum,blood and pleural effusion from patients with bronchopulmonary candidiasis in our respiratory department were collected since from Jul 2007 to Jun 2007.All of patients carried out APACHEⅡ integrating,according to the results of APACHEⅡsubset to Knaus equations to calculate the risk of death during hospital stay.RESULTS Twenty-two strains of fungi were isolated from 119 patients(18.4%).Blood gas analysis of severe COPD patients indicated a respiratory failure tendency,the fungal detection rate was higher than that of mild or median COPD patients.The higher of APACHEⅡ accumulated points,the higher of fungal detection rate,and the higher of risk of death.CONCLUSIONS The most organisms in respiratory tract infection are bacterium.With number of admission times in hospital and severity of pathogenetic condition increased are,the opportunity of fungal infection is raised.Furthermore,the fungal infection associatively with exacerbation.Fungi become the ascendant causative organisms inducing the decrese in pulmonary function and severity of patients,we should think about of it when the therapeutic efficacy is worse.

Objective To study the expression level and clinical significance of Galectin-3 and miRNA-21 in non-small-cell lung carcinoma(NSCLC).Methods One hundred and fifty patients with NSCLC were chosen as cancer group,and 1 50 patients with benign pulmonary diseases were chosen as control group.The expression level of Galectin-3 and that of miRNA-21 between two groups were compared,and the relevance between expression level of Galectin-3 and that of miRNA-21 and clinical feature were analysed.Results In cancer group,the expression level of Galectin-3 was 6.75±2.38,and that of control group was 1.12 ±0.29;the expression level of miRNA-21 was 5.91 ± 1.59,and that of control group was 0.97 ± 0.1 7,and the difference between two groups had statistical significance(P <0.05 ).The relevance between expression level of Galectin-3 and stage,differentiation,lym-phatic metastasis,diameter of carcinoma and PFS,OS of patients had statistical significance(P <0.05).The relevance between ex-pression level of miRNA-21 and stage,differentiation,diameter of carcinoma and PFS,OS of patients had statistical significance(P <0.05).In the diagnosis of NSCLC,the sensitivity of the expression level of Galectin-3 was 90.20%,and its specificity was 70.69%, while the sensitivity of expression level of miRNA-21 was 88.24% and its specificity was 69.97%.The difference between the di-agnostic value of Galectin-3 and that of miRNA-21 had no statistical significance(P >0.05 ).Conclusion The expression level of Galectin-3 and that of miRNA-21 can be applied in the diagnosis and prognosis of non-small-cell lung carcinoma.