There are the descriptions on the development of domestic and international biological systems' modeling and simulation as well as the importance of course for undergraduates. The curriculum structure is discussed about the basic knowledge of modeling and simulation, traditional methods of modeling and simulation on biomedical engineering indus- tries and academic fields, visual modeling and simulation of blood circulatory system and model analysis of biological sta- tistical information, etc. On the basis of teaching experience, the method how to combine curriculum structure and scien- tific research field is explored, and one pattern is provided that could induce undergraduates to as soon as possible study science and research on professional knowledge for the biomedical engineering undergraduate courses. It is an inevitable trend of combination between curriculum and scientific research to develop the construction of our country undergraduate courses.