Aneusomy is an early genetic event and a characteristic feature of many solid tumors. It is often associated with poor prognosis in cancer patients. The involvement of PAX8-PPARγ rearrangement in tumorigenesis of follicular thyroid lesions has been widely assessed. However, there were few reports on aneusomy of the PPARγ gene at the 3p25 locus in follicular thyroid lesions. It remains undetermined whether these abnormalities can be translated into improved diagnosis, classification, or outcome prediction. Herein, we report three cases of follicular thyroid neoplasms [two follicular thyroid carcinomas (FTCs) and one Hurthle cell adenoma (HCA)] with 3p25 aneusomy detected by fluorescence in situ hybridization (FISH). 3p25 trisomy was observed in one FTC and one HCA while 3p25 tetrasomy was observed in one FTC. Furthermore, all three lesions did not show overexpression of PPARγ protein. Hurthle cell neoplasms (HCN) are distinct clinically and histologically from other follicular thyroid neoplasms (FTN). However, the presence of the aneusomy in HCA and FTC indicates that there could be a biological continuum between the two and chromosomal gains might play an important role in the pathogenesis of these two types of neoplasms. Despite their differences, HCN and FTN may share the same early genetic event in tumour development.

A 47-year-old lady, presented with progressive proptosis of left eye with deterioration of vision. She had a history of left solitary fibrous tumour and had undergone left frontal craniotomy and orbitotomy in 2004. Surveillance Magnetic resonance imaging (MRI) six years later showed tumour recurrence with intracranial extension. However, she did not follow-up and only presented again 3 years, later. Tumour resection and left exenteration was performed. Histology showed ‘patternless’ pattern of neoplastic cells, and CD34 staining was diffusely positive. Diagnosis of recurrent solitary fibrous tumour with intracranial extension was made.
Solitary Fibrous Tumors ; Neoplasms

Solitary fibrous tumour (SFT) adalah neoplasma fibrotik, juga dikenali sebagai hemangiopericytoma. STAT6 merupakan protein yang berfungsi sebagai transduser isyarat dan penggerak transkripsi keluarga STAT6 dalam fungsi imun dan pertumbuhan sel awal. Perubahan onkogen STAT6 memainkan peranan penting sebagai pemacu tertentu untuk genetik SFT melalui gen gabungan NAB2-STAT6. Tujuan kajian ini adalah untuk membandingkan dan menilai ekspresi STAT6 di antara SFT dan tumor yang menyerupai SFT. Kami menilai sebanyak 30 kes blok tisu parafin yang sebelum ini didiagnosis SFT (n=14) dan tumor yang menyerupai SFT (n=16) selama tempoh 15 tahun. Empat belas kes SFT (100%) menunjukkan ekspresi nuklear STAT6. Semua jenis tumor yang lain adalah negative untuk STAT6 kecuali satu kes liposarcoma dediferensiasi satu tumor stromal gastrointestinal dan satu lipoma yang menunjukkan pewarnaan sitoplasma yang tidak spesifik dan lemah. Ekspresi nuklear STAT6 adalah berguna dan boleh dipercayai sebagai penanda adjunksi SFT apabila diagnosis tidak boleh dibuat melalui kaedah konvensional.