Background: Burnout has become a problem that is increasing among doctors. Burnout syndrome consists of emotional exhaustion, depersonalization, and reduced personal accomplishment, which results from the accumulation of stress in a workplace. Objectives: This study aimed to determine the prevalence and associated factors of burnout among resident doctors in Tabuk, Saudi Arabia. Methods: A cross-sectional study was conducted among 230 resident doctors at King Salman Armed Forces Hospital in Northwestern Region in Tabuk City, Saudi Arabia between September 2020 and January 2021. Data were collected by using a self-administered questionnaire. The Maslach Burnout Inventory Human Services Survey for Medical Personnel (MBI-HSS (MP)) was used to measure burnout. Sources of stress were assessed by 20 items. Univariate and multivariate analysis were used to examine the factors associated with burnout. Results: The overall prevalence of burnout was 89.1%. This study found that 32.2% of participants scored high on all the subscales. Burnout was associated with gender (p=0.012), chronic disease (p=0.018), level of training (p<0.05), dissatisfaction with work-life balance (p<0.001), work overload (p<0.001), and sources of stress in the workplace (p<0.05). Conclusion: The prevalence of burnout among medical residents in Tabuk was high. Burnout was mainly associated with work-related sources of stress. There is a need for a comprehensive assessment of burnout and stress among medical residents at different levels and specialties. Thus, these findings may help diagnose such problems earlier and trace them to find better solutions,