Objective: To evaluate the therapeutic effects of early enteral nutrition in the treatment of severe acute pancreatitis by nasojejunal tube.Methods: Forty-one cases of SAP were retrospectively analyzed and divided into 2 groups.There were 20 cases in conventional therapy group and 21 cases in enteral nutrition group.Major causes,treatments and clinical results were analyzed and APACHEⅡ score,CT score,serum albumin and prealbumin were compared between two groups.Results: Fortyone cases were cured and no one needed surgical intervention except six pateints with pseudocysts.EN cases were fed via a nasojejunal tube placed at the seventh day after admission.EN was well tolerated throughout the course of disease.The improvement of APACHEⅡ score of the EN group was significantly higher than that of conventional therapy group(P

Objective Visceral hypersensitivity is an important feature of irritable bowel syndrome (IBS). This investigation was to establish an animal model of visceral hypersensitivity associated with IBS, and to test its effectiveness by two different ways. Methods The model was established by intrarectal administration of acetic acid daily in the neonatal rats between postnatal 8 and 21 days. The threshold of abdominal withdrawal reflex(AWR) was evaluated during rectal distension at postnatal 6,8 and 10 weeks respectively, and the changes of rectal sensitivity were identified by the abdominal electrical activity measured at postnatal 12 weeks. Results In contrast to neonatal rats subjected to saline intrarectally (NS group) and adult rats subjected to acetic acid intrarectally (AA group), neonatal rats subjected to acetic acid intrarectally(NA group) showed a significant decrease(P

Objective It has been know that visceral hypersensitivity is one of the important features of irritable bowel syndrome(IBS) and psychological factors may be implicated in the etiology of IBS. The aim of our study was to investigate the influence of an acute psychological stress on the rectal sensitivity in rats and the role of mast cell in this response. Methods A stress model was established by mild restraint lasting 2 hours and the effect of acute stress on visceral sensitivity to rectal distension(RD) was measured by abdominal electromyography. The number of mast cells was counted and mast cell activation was determined by histamine release after in vitro stimulation with substance P(SP) in colonic pieces from stressed and control rats. We also studied the effect of acute stress on somatic nociception and colonic transit. Results Abdominal response to RD for all volumes of distension(0.5, 0.8, 1.2, 1.6 ml)was significantly enhanced by acute restraint stress compared with sham stress( P 0.05 ). Acute stress also stimulated colonic transit and produced significant somatic analgesia. Conclusion Acute stress enhanced rectal sensitivity in response to rectal distension and colonic mast cell activation may be involved in this response.