In medical researches,large-scale collaborations spanning institutions and disciplines have emerged a key pattern for tackling major research subjects.Contract writing for medical research collaboration,as a legal means to address the rights and obligations of the parties,should be fair,reasonable,scientific and strict as much as possible.The author probed into problems found in current writing of medical research contracts,and came up with corresponding remedies.

Capillary leak syndrome (CLS) is a common and life-threatening disorder in children.The common pathogenies are sepsis,severe trauma,shock,asphyxia,extracorporeal circulation,ischemical reperfusion injury and so on.It is characterized by shock resulting from leakage of plasma,which is refected by accompanying hemoconcentration,hypoalbuminemia and edema,sometimes followed by multiple organ dysfunction syndrome.Clinicians should consider the diagnosis in patients with unexplained edema and hypotension.To know the pathophysiology and clinical course will be benefit to proper medicine choosen.

AIM: To introduce a new kind of wrist-hand orthosis.METHODS: The major frame of wrist-hand orthosis is composed of dorsal carpal guard plate and carpal bracket; while, a U-shaped anterior bracket is fixed on the anterior side of the major frame. Ferrules of index finger, middle finger, fourth finger and little finger respectively connect to dorsal carpal guard plate of the major frame via elastic brace; ferrule of thumb is fixed on one side of ferrule of index finger by using steel wires; an abduct elastic sleeve is designed on the lateral dorsal carpal guard plate of ferrule of little finger by using steel wires. According to experimental demands, wrist with the palms upward or downward puts into the major frame, which is composed of dorsal carpal guard plate and carpal bracket. The hand is anterior to the major frame; ferrules are located over rolling sleeve by forward and fingers are located below the rolling sleeve by forward; ferrules are respectively rang the index, middle, fourth and little fingers; ferrule of thumb is rang the thumb. Continuously, wrist rotates based on orthopaedic demands to realize various orthopaedic functions.RESULTS: The wrist-hand orthosis is used to help the hand maintain extension after extensor tendon injury operation in order to restrict active areas of fingers and promote healing of injured side. On the other hand, this new orthosis is also used to help wrist joint and digital joint maintain flexion after extensor tendon injury operation in order to improve flexion and extension of wrist joint, enlarge active area of flexion of wrist joint, enlarge drifting active area of radialis of wrist joint, and increase muscle strength of radial flexor muscle, ulnar flexor muscle, extensor carpi radialis muscle, extensor carpi ulnaris muscle, extensor carpi ulnaris muscle, flexor carpi ulnaris muscle, extensor digitorum communis muscle, superficial flexor muscle and deep flexor muscle.CONCLUSION: The wrist-hand orthosis refers to protection of wrist and hand after operations of nerve, tendon, muscle and vessel injuries and recovery of motor dysfunction of wrist joint and digital joint induced by wrist-hand fracture; on the other hand, this new orthosis can improve active area of wrist joint and strengthen muscle force.

Aged, 80 and over ; Heart Septal Defects, Atrial ; Humans ; Male

To create a novel kind of orthosis to correct the dysfunction of antebrachium, wrist, metacarpus and digit and to facilitate the protection and functional training after injury of forearm and hand. The orthosis is constituted of a cardinal shelf, a stem shelf of metacarpophalangeal joint, a front bracket, finger ferrules, elastic strings and steel wires. The cardinal shelf is composed of a backplate for dorsal palm and a bracket for wrist with a U-shaped rack fixed in front of it. Ferrules of index finger, middle finger and fourth finger and little finger are connected to the backplate on the cardinal shelf through elastic strings. The thumb ferrule is set outside the ferrule of index finger on the backplate with steel wires. Another ferrule that is used to enclose the wrist and antebrachium is linked to the crossbar of the U-shaped rack through elastic strings. This orthosis plays an effective role in the protection of nerves, tendons, extremity of vascular anastomosis and the prevention of allotopia after fracture due to different trainings. It can improve the range of motion of wrist joint, metacarpophalangeal joint, and articulationes interphalangeae and strengthen the muscle power of pronator teres, pronator quadratus, supinator, wrist extensor, wrist flexor, extensor digitoium, perforans manus and musculus flexor digitorum sublimes. This orthosis could be applied for patients after the operation of antebrachium,wrist and manus to promote the recovery of their functions.

Objective:To investigate the protection mechanism of adenosine A1 receptor agonist(2-chloro-N6-cyclopentyladenosine, CCPA)delayed preconditioning for rabbit myocardium during ischemia reperfusion.Methods:Thirty New Zealand male white rabbits were randomly assigned to Sham group,I/R group and CCPA group,with ten in each.Group CCPA was given CCPA 0.1 mg/kg before myocardial ischemia.Twenty-four hours later the I/R and CCPA underwent 40 min of coronary occlusion followed by 2 h of reperfusion.Blood samples were taken from arterial line at 20 min before occlusion(T)1,20 min after occlusion(T2),40 min after occlusion(T)3,1 h after reperfusion(T)4and 2 h after reperfusion(T)5for determination of the plasma levels of IL-10.At the end of the reperfusion,infarct size(IS)and area at risk(AAR)were defined by Evans blue and TTC staining.The heart was harvested and levels of the HSP70 were determined by Western blot analysis,and ultrastructures were observed under the electron microscopy.Results:The IL-10 and HSP70 levels of group CCPA was higher than those of group I/R.The CCPA(P

Objective:To explore the efficiency of comprehensive sedation nursing in MRI examination to the epilepsy children underthe age of 4.Methods:180 children were randomly divided into the test group and the control group.The test group was given comprehensive sedation nursing,while the control group was only given the simple drug sedation by oral medicine called 10%chloral hydrate.The effective rate,the time children fell to sleep after given the drug and one-time success rate were recorded and analyzed between the two groups.Results:The effective rate,the time children fell to sleep after giving the drug and one-time success rate all have siganificant difference between these two groups(P

Objective:To study acute toxicity of Xidan suspensions in mice.Methods:To measure the LD50 and to observe the response to machinery stimulation and the autonomic activity of the experimental animals when Xidan suspensions is taken orally into the mice.Results:The LD_(50) of Xidan suspensions is 148.08g(crude medicinal materials)/kg in the mice by ig.When it is taken orally(ig)into the mice at the dosage of LD_(50) or more [180g(crude medicinal materials)/kg],it is found that the response to machinery stimulation,the autonomic activity the muscle tone and the regulation of balance ability decreased obviously.Conclusion:It is indicated that Xidan suspensions could be toxic to the nervous system of mice.

Objective:To study anti-tumor activity of Xidan Suspensions in vivo.Methods: The mice were transported by armpit or intraperitoneum injection of H22,EC or P388 tumor cells.Results: Xidan Suspensions inhibited markedly the growth of H22,EC or P388 tumor cells(P

AIM: The fingerprints of Acanthopanax Senticosus(Puper.et Maxim) Harms was studied by microemulsion electrokinetic chromatography(MEEKC) in comparison with micellar electrokinetic capillary chromatography(MEKC) and capillary zone electrophoresis(CZE). METHODS: The electrophoretic electrolyte was composed of a 1.0 %(w/w) SDS,6.6 %(w/w) n-butanol,0.7 %(w/w) n-heptane,91.6 %(w/w) 25 mmol/L borate solution(adjusted pH 9.5 with NaOH solution). RESULTS: The MEEKC-FP had good precision,stability and reproducibility with the relative standard deviations(RSD) of the relative migration time less than 3.4 % and the RSD of the relative peak area was about 6.3 %. CONCLUSION: This method provides a standard for the better quality controlling of Acanthopanax Senticosus(Puper.et Maxim) Harms.than MEKC and CZE.