The status and progress in research of anti-AIDS agents at home and abroad are reviewed, some suggestions have been made for further steps in this research work.

OBJECTIVE: There are some people in population susceptible to acute mountain sickness. Therefore, it is important to analyse, assess and integrate certain research results to build prediction system and mathematics model in order to predict those susceptible people when army goes to tableland.DATA SOURCES: Computer was used to search databases such as Medline, PubMed and PML to find articles regarding prediction of people susceptible to acute mountain sickness from January 1970 to December 2002 with the search words "acute mountain sickness, susceptible population,prediction" . The language was limited to English. At the same time, Chinese Journal Full-text Database, Chinainfo and CBMdisc were searched to find articles from January 1970 to August 2004 by the Chinese language of "acute mountain sickness, susceptible population and prediction". The research targets are susceptible people to acute mountain sickness. At last,trace-back method was used to supplement some literature and monographs.DATA SELECTION: After systematically analyzed and concluded the literature information and screened researches without conducting experiment, full text of the rest literature was searched and used as selective criteria if it could be used as prediction indicator of susceptible people to acute mountain sickness.DATA EXTRACTION: Totally there were 19 prediction indicators generalized. After conducting systemic analysis, Delphi method and analytic hierarchy process(AHP) to the indicators, 13 were selected while the other 6 were excluded.DATA SYNTHESIS: The indicators were classified according to nervous-humoral regulation ability, oxygen capture ability of respiratory system,anti-anoxia ability of central nervous system, mental health and health service ability. Based on these, system analysis, Delphi method and AHP method were used to screen prediction indicators, establish indictor system, confirm the weighted indicators and weighted indicator system as well as standardize the prediction indicators.CONCLUSION: According to the principle of prediction model and model methods, weighted linear synthesis method was used to build the predictive mathematic model. The project of susceptible population prediction of acute mountain sickness in army when entering tableland urgently was proposed combining the health service ability of army.

Acupuncture Therapy ; Adult ; Bursitis ; immunology ; therapy ; Chronic Disease ; therapy ; Female ; Hip Joint ; immunology ; Humans ; Male ; Middle Aged

Objective: To establish the ultrafiltration process of concentrating insulin-like growth factor-1 (IGF-1) from Cervi Cornu Pantotrichum (CCP). Methods: The ultrafiltration technique was utilized to concentrate the IGF-1 with CCP freeze-dried powder as raw material. The polyethersulfone (PES) membrane and modified PES membrane were compared and studied. The effects of relative molecular weight cutoff (RMWCO), pressure, and pH value on IGF-1 ultrafiltration process were investigated. Furthermore, the cleaning methods were investigated, and the optimal conditions were obtained. Results: The optimal conditions were as follows: The RMWCO of PES membrane was 4 000, the RMWCO of modified PES membrane was 5000, the pressure was 0.3 MPa, and the pH value was 12. The recovery rate of IGF-1 and protein reached 68.32% and 69.20%, respectively by the PES membrane, while the recovery rate of IGF-1 and protein reached 57.17% and 87.43% respectively by the modified PES membrane. Four different methods were employed to clean the membrane. The results showed that the membrane immersed in 0.4% NaOH-0.1% NaClO solution for 24 h was the appropriate cleaning method, by which the PES membrane permeation flux recovery rate could reach 98.65% and the modified PES membrane permeation flux recovery rate could reach 93.75%. Conclusion: The IGF-1 could be easily concentrated and separated using the ultrafilter condensing technique. The process is easy and stable, and the membrane is easy to be cleaned and has high recovery rate, which has the high potential of industrial production and application.

Objective To evaluate the quality of examination papers of otolaryngology among students of grade 2007 in the first clinical college of Chongqing Medical University.Methods Totally 202 copies of examination papers of otolaryngology from grade 2007 students in our college were taken as research references.SASS 15.0 software was used to statistically analyze total score of every student and score of each question.Mean score,standard deviation,difficulty coefficient and discrimination coefficient of each question were counted and normality test was conducted.Results Scores were in negative skewness distribution,with mean score of 80.9,standard deviation of 10.9,the lowest score of 56.5,the highest score of 98.0,difficulty coefficient of 0.781,and discrimination coefficient of 0.308.Conclusions Examination papers are well designed and discriminated and can objectively reflect students' command of the course.However,distribution of sores is unreasonable and examination paper is relatively easy to complete,indicating the weakness in the teaching process.

Objective To isolate and observe Pityrosporum yeasts from a patient with onychomycosis. Methods The involved nail specimens were investigated by means of culture, pathological and scanning electron microscopic examination and 20% KOH preparation. Results Physical examination showed that each finger and toe nail appeared brownish black, rough and thick, some of the fore part of the nail plate detached from the nail bed. Fingernail specimen's culture results showed that Trichophyton rubrum grew on Sabouraud's dextrose agar and Pityrosporum ovale grew on the medium containing rapeseed oil. The pathological examination revealed P.ovale yeast involvement in the fissure of the nail plate. Under the scanning electron microscopy, a lot of P.ovale yeasts with characteristic collarette structure inserted in the nail tissue was noticed. In the 20% KOH preparations of nail incubated at 56℃for 1h and stained with Quink Parker ink, spores and hyphae were identified morphologically with P.ovale and T.rubrum respectively. The patient received intermittent pulse therapy with itraconazole, the color of the nails became much brighter 1 to 2 months after the fourth cycle of therapy, but no further improvement was observed afterwards. P.ovale and T.rubrum grew again 6 months after treatment when the clippings of the fingernail were cultured. Conclusion This is the first document of onychomycosis related with P.ovale in China.

Objective To study the efficacy of consecutive drugs in the treatment of chronic prostatitis. Methods 153 cases of moderate & severes chronic prostatitis were treated with consecutive drugs with sensitive antibiotics,? 1-blocker,inhibitor of cox-2 and traditional Chinese herb,20 cases being chronic bacterial and 133 nonbacterial. They were classified and evaluated according to the CPSI & EPS examinations as analyzed by T test. Results All cases were followed up for an average of 11.8 months(8～18 months).The average CPSI score was 32.6(32.7?5.3) before treatment and 13.4(12.8?7.3) after treatment (P

As a new therapy in past twenty years,biological agents have been approved for the treatment of inflammatory bowel disease (IBD). However,biological agents currently used for IBD treatment require intravenous or subcutaneous injections,and some require infusion under close observation. Therefore,it is of positive clinical significance to find a safe and effective oral biological agent. This article reviewed recent advances in study on novel oral biological agents in the treatment of IBD.

Objective To analyse the personality characteristics of medical undergraduate and graduate newcomers. Methods Cattell 16 Personality Factor Questionnaires (16PF) were employed to assess the personality of 675 undergraduate newcomers (306 males and 369 females) and 155 graduate newcomers (76 males and 79 females),and the results were compared with the established findings of the country. Results Compared with male undergraduate newcomers,the scores of rule-consciousness,self-reliance and environmental adaptation of male graduate newcomers were higher,while those of sensitivity,openness to change,tension,cowardice and bravery were lower (P

Objective To observe the clinical effect of electroacupuncture combined with massage in the treatment of cervical spondylotic radiculopathy.Methods 120 patients with cervical spondylotic myelopathy who were treated in Wuhan Traditional Chinese and Western Medicine Hospital from October 2015 to December 2016 were randomly divided into control group and study group.The control group was treated with electroacupuncture.The control group was treated in the control group on the basis of the treatment of massage, compared the two groups of patients with treatment, before and after treatment changes in symptoms, and the treatment of adverse events during the situation.Results The total effective rate was 96.67% in the study group, which was significantly higher than that in the control group(81.67%, P<0.05).The clinical symptoms and work of the two groups before treatment were statistically significant (P<0.05).The scores of the three groups were significantly higher than those of the control group (P<0.05).The adverse events of the study group were significantly higher than those in the control group (P<0.05)The incidence was slightly lower than the control group, the difference was not statistically significant.Conclusion Electroacupuncture combined with massage can effectively improve the total effective rate of treatment, alleviate the clinical symptoms, reduce the incidence of adverse events and improve the safety, and show good application prospects.