1.Ameliorating effects of Raphanus sativus leaves on sodium arsenite-induced perturbation of blood indices in Swiss albino mice
Dilruba SAYADA ; Hasibuzzaman M. M. ; Rahman MASHIUR ; Mohanto Chandra NAYAN ; Aktar SHARMIN ; Rahman ATIQUR ; Hossain Imam MD ; Nikkon FARJANA
Asian Pacific Journal of Tropical Biomedicine 2017;7(10):915-920
Objective: To evaluate the ameliorating effects of Raphanus sativus leaves (RSL) against sodium arsenite(Sa)-induced adverse effects through mice experiments. Methods: Swiss albino mice were divided into four equal groups: control, Sa, RSL, RSL + Sa. Sa (10 mg/kg body weight/day), and powder form of RSL (50 mg/kg body weight/day) were provided as food supplement orallty. Blood indices were measured using commercially available kits through colorimetric methods. Results: It was observed that lactate dehydrogenase, alkaline phosphatase, alanine aminotransferase,and aspartate aminotransferase activities were significantly(P<0.05) higher in Sa-treated mice than those in the control group.RSL significantly reduced Sa-induced elevation of the activities of these enzymes in serum significantly (P < 0.05). Serum butyrylcholinesterase activity and high density lipoproteins cholesterol levels in Sa-treated mice were significantly (P < 0.05) lower than the control group, and the food supplementation of RSL could significantly(P<0.05)prevent the reduction of Sa-mediated serum butyryl cholinesterase activity and high density lipoproteins cholesterol levels.RSL could also reduce the Sa-induced elevation of serum urea level significantly(P<0.05). Conclusions: Results of this study suggest the protective or ameliorating effects of RSL on Sa-induced perturbation of blood indices are related to the hepatic,cardiovascular and kidney dysfunction.Therefore,RSL may be useful to reduce arsenic toxicity in human in the future.
2.Protective effects of Moringa oleifera Lam. leaves against arsenic-induced toxicity in mice
Sheikh Afzal ; Yeasmin Fouzia ; Agarwal Smita ; Rahman Mashiur ; Islam Khairul ; Hossain Ekhtear ; Hossain Shakhawoat ; Karim Rezaul Md ; Nikkon Farjana ; Saud Alam Zahangir ; Hossain Khaled
Asian Pacific Journal of Tropical Biomedicine 2014;(z1):353-358
Objective: To evaluate the protective role of leaves of Moringa oleifera (M. oleifera) Lam. against arsenic-induced toxicity in mice.Methods:non-treated control group while, the second, third, and fourth groups were treated with M.oleifera leaves (50 mg/kg body weight per day), sodium arsenite (10 mg/kg body weight per day) and sodium arsenite plus M. oleifera leaves, respectively. Serum indices related to cardiac, liver and renal functions were analyzed to evaluate the protective effect of Moringa leaves on arsenic-induced effects in mice.Results:Swiss albino male mice were divided into four groups. The first group was used as induced elevation of triglyceride, glucose, urea and the activities of alkaline phospatase, aspartate aminotransferase and alanine aminotransferase in serum. M. oleifera leaves also prevented the arsenic-induced perturbation of serum butyryl cholinesterase activity, total cholesterol and high density lipoprotein cholesterol.Conclusions:The results indicate that the leaves of M. oleifera may be useful in reducing the It revealed that food supplementation of M. oleifera leaves abrogated the arsenic-effects of arsenic-induced toxicity.
3.Protective effects of Moringa oleifera Lam. leaves against arsenic-induced toxicity in mice.
Afzal SHEIKH ; Fouzia YEASMIN ; Smita AGARWAL ; Mashiur RAHMAN ; Khairul ISLAM ; Ekhtear HOSSAIN ; Shakhawoat HOSSAIN ; Md Rezaul KARIM ; Farjana NIKKON ; Zahangir Alam SAUD ; Khaled HOSSAIN
Asian Pacific Journal of Tropical Biomedicine 2014;4(Suppl 1):S353-8
OBJECTIVETo evaluate the protective role of leaves of Moringa oleifera (M. oleifera) Lam. against arsenic-induced toxicity in mice.
METHODSSwiss albino male mice were divided into four groups. The first group was used as non-treated control group while, the second, third, and fourth groups were treated with M. oleifera leaves (50 mg/kg body weight per day), sodium arsenite (10 mg/kg body weight per day) and sodium arsenite plus M. oleifera leaves, respectively. Serum indices related to cardiac, liver and renal functions were analyzed to evaluate the protective effect of Moringa leaves on arsenic-induced effects in mice.
RESULTSIt revealed that food supplementation of M. oleifera leaves abrogated the arsenic-induced elevation of triglyceride, glucose, urea and the activities of alkaline phospatase, aspartate aminotransferase and alanine aminotransferase in serum. M. oleifera leaves also prevented the arsenic-induced perturbation of serum butyryl cholinesterase activity, total cholesterol and high density lipoprotein cholesterol.
CONCLUSIONSThe results indicate that the leaves of M. oleifera may be useful in reducing the effects of arsenic-induced toxicity.