1.Pain in Times of Stress
Asma Hayati Ahmad ; Rahimah Zakaria
Malaysian Journal of Medical Sciences 2015;22(Special Issue):51-60
Stress modulates pain perception, resulting in either stress-induced analgesia or stress-induced hyperalgesia, as reported in both animal and human studies. The responses to stress include neural, endocrine, and behavioural changes, and built-in coping strategies are in place to address stressors. Peculiar to humans are additional factors that modulate pain that are experienced in times of stress, notably psychological factors that potentially influence the directionality of pain perception.
2.Klebsiella Pneumoniae Liver Abscess With Hematogenous Long Bone Osteomyelitis
Malaysian Orthopaedic Journal 2019;13(Supplement A):138-
3.Distribution of alpha thalassaemia in 16 year old Malaysian Students in Penang, Melaka and Sabah
Rahimah Ahmad ; Nisha Sabrina ; Safiah Bahrin ; Roshida Hassan ; Punithawathy Yelumalai ; Nurul Hidayat ; Syahzuwan Hassan ; Zubaidah Zakaria
The Medical Journal of Malaysia 2012;67(6):565-570
Objectives: Alpha thalassaemia is wide spread in Malaysia
and is a public health problem. This study aimed to describe the carrier frequencies of α‒thalassaemia and its
distribution among major ethnic groups in three states of
Malaysia.
Methods: Educational forums were organised and study was
explained to students from three schools. Students were
invited to take part in the screening with parent consent. A total of 8420 adolescent students aged 16 years volunteered to participate in the study. Peripheral blood samples were analysed for complete blood counts, haemoglobin quantification and typing, and serum ferritin levels. Genomic DNA was used for screening alpha thalassaemia alleles by PCR based molecular methods.
Results: We identified seven α‒globin gene defects in 341
(4.08%) students: amongst them α+‒ and α0‒thalassaemias
were detected in 232 (2.77%) and 107 (1.28%) students
respectively. Genotype ‒α3.7/αα was the most prevalent
among sub-populations of Malay, indigenous communities
of Sahab and Indian, while ‒‒SEA/αα deletion is more
prevalent in Malaysian Chinese. It is estimated that 63
pregnancies annually are at risk of Hb Bart’s hydrops fetalis.
Conclusions: We have demonstrated the prevalence and
mutation patterns of α‒thalassaemia in the 16 year olds in
three states of Malaysia. High α0‒thalassaemia deletions
amongst the study subjects place these carriers at an
increased risk of conceiving fetuses with HbH disease and
Hb Bart’s hydrops fetalis should they choose another
heterozygous partner. It is therefore highly recommended to
institute community screening programmes and provide
prospective carriers with genetic counselling to help them
make informed choices.
4.Detection of β-globin Gene Mutations Among β-thalassaemia Carriers and Patients in Malaysia: Application of Multiplex Amplification Refractory Mutation System– Polymerase Chain Reaction
Syahzuwan Hassan ; Rahimah Ahmad ; Zubaidah Zakaria ; Zefarina Zulkafli ; Wan Zaidah Abdullah
Malaysian Journal of Medical Sciences 2013;20(1):13-20
Background: β-thalassaemia is one of the most common single-gene disorders worldwide. Each ethnic population has its own common mutations, accounting for the majority of cases, with a small number of mutations for the rarer alleles. Due to the heterogeneity of β-thalassaemia and the multi-ethnicity of Malaysians, molecular diagnostics may be expensive and time consuming.
Methods: A simple polymerase chain reaction (PCR) approach involving a multiplex amplification refractory mutation system (MARMS) and one amplification refractory mutation system (ARMS), consisting of 20 β-globin gene mutations, were designed and employed to investigate β-thalassaemia patients and carriers.
Results: Out of 169 carriers tested with the MARMS, Cd 41/42 (–TTCT), Cd 26 (A–G) HbE, IVS 1–1 (G–T), and IVS 1–5 (G–C) were the most common mutations, accounting for 78.1%. Among the Malays, Cd 26 (A–G) HbE, Cd 41/42 (–TTCT), IVS 1–1 (G–T), and IVS 1–5 (G–C) were the most common mutations, accounting for 81.4%, whereas Cd 41/42 (–TTCT) and IVS 2–654 (C–T) were most common among the Chinese (79.1%).
Conclusion: We propose the use of this cheap, easy to interpret, and simple system for the molecular diagnostics of β-thalassaemia among Malaysians at the Institute for Medical Research (IMR)
7.Correlation Of FRAX Risk Score And Hip Fragility Fractures In Elderly Patients
Syed Ahmad Kabeer SJ ; Mohd Farid M ; Nur Atiqah MJ ; Zulaikha Z ; Mohammad Rostam S ; Ikhwan S ; Naim N ; Kuhanrajan R ; Syahril RA ; Kamarul Haqq AG ; Kamil MK
Malaysian Orthopaedic Journal 2018;12(Supplement A):237-
8.Haemoglobin Sickle D Punjab: - A Case Report
Rahimah Ahmad ; Syahira Lazira Omar ; Siti Hida H M Arif ; Faidatul Syazlin A Hamid ; Nur Aisyah Aziz ; Nik Hafidzah N Mustapha ; Zubaidah Zakaria
The Medical Journal of Malaysia 2014;69(1):42-43
Haemoglobin S D-Punjab is a rare compound heterozygous
haemoglobinopathy characterised by the presence of two β
globin gene variants: β6(GAG→GTG) and β121(GAA→CAA).
These patients’ clinical and haematological features mimic
haemoglobin S disease. We describe the first case of doubly
heterozygous HbSD-Punjab from Malaysia managed with
regular blood transfusion at the age of one. This case
highlights the propensity for occurrence of rare phenotypes
within our multi-ethnic population and emphasises the
importance of accurate genotyping to avoid erroneous
counselling, and to plan an effective patient management
strategy before complication evolves.
9.Retrospective Analysis of Patch Test Results Between 2011 and 2013 in Hospital Selayang, Malaysia
Fei Yin NG ; Wan Ahmad Kamal Wan Syameen Afira ; Logesh A/P SINNAIYAH ; Hazfaneza Ab HALIM ; Rohna RIDZWAN
Malaysian Journal of Dermatology 2018;40(June):6-9
Introduction:Patch test is the gold standard diagnostic test for contact allergy. Periodic analysis of the trend ofcontact allergy provides a valuable guide to clinicians. We aim to study the pattern of contact allergyin adults at Hospital Selayang.Methods:This is a retrospective review of patch test data in adults suspected with allergic contact dermatitisbetween January 2011 and December 2013 at Hospital Selayang.Results:There were 705 subjects with 247 males (35%) and 458 females (65%). At least 1 positive reactionwas detected in 546 (77.4%) subjects patch tested with European Baseline Series (EBS) and additionalseries. The top 5 common allergens in the EBS were nickel sulfate (28.7%), cobalt chloride (13.6%),paraben mix (11.6%), balsam of peru (10.6%), and potassium dichromate (10.5%). Among thosepatch tested with rubber additives series, the top 3 allergens were N,N-Diphenylguanidine (DPG),N-Cyclohexyl-N-phenyl-4-phenylenediamine (CPPD), and N-Cyclohexylthiophthalimide. Of thetop 5 common allergens in the group tested with fragrance series, all except Ylang ylang oil werecomponents of fragrance mix I. Among the subjects tested with fragrance series, the top 5 commonallergens were individual components of fragrance mix I and Ylang ylang oil.Conclusion:A multicentre study would reflect better the pattern of allergen exposure of the nation. Furtherevaluation of the prevalence of contact allergy to DPG, CPPD, N-Cyclohexylthiophthalimide andYlang ylang oil would guide the need to incorporate these allergens in routine testing along with EBS.
10.Surgical Management of Distal Tibia Fracture: Towards An Outcome-based Treatment Algorithm
Rushdi I ; Che-Ahmad A ; Abdul-Ghani KAH ; Mohd-Rus R
Malaysian Orthopaedic Journal 2020;14(No.3):57-65
Introduction: Distal tibia fractures are frequently associated
with an extensive soft tissue injury which then leads to a
higher risk of complications such as infection, non-union and
eventually poor overall outcome. The purpose of this study is
to measure the outcome of distal tibia fractures treated with
internal fixation, external fixator or Ilizarov external
fixator(IEF). We aim to propose an algorithm for
management of distal tibia fractures by evaluating the
treatment options, outcomes and risk factors present.
Material and Methods: This study is a cross-sectional study
of all distal tibia fractures treated surgically in Tengku
Ampuan Rahimah Hospital, Klang from 1st January 2016 till
30th June 2018. Patient records were reviewed to analyse the
outcomes of surgical treatment and risk factors associated
with it.
Results: Ninety-one patients were included with a mean age
of 41.5 years (SD = 16.4). Thirty-nine cases (42.9%) were
open fractures. Thirty-eight patients (41.8%) were treated
with internal fixation, 27 patients (29.7%) were treated with
IEF and 26 patients (28.6%) were treated with an external
fixator. Among open fractures cases, no significant finding
can be concluded when comparing each surgical option and
its outcome, although one option was seen better than the
other in a particular outcome. Initial skeletal traction or
temporary spanning external fixator in close fractures
reduced the risk of mal-alignment (p value=0.001). Internal
fixation is seen superior to IEF and external fixator in close
fractures in term of articular surface reduction (p value =
0.043) and risk of mal-alignment (p value = 0.007).
Conclusion: There is no single method of fixation that is
ideal for all pilon fractures and suitable for all patients. This
proposed algorithm can help surgeons in deciding treatment
strategies in the challenging management of distal tibia
fractures to reduce associated complications.