1.Zero-line Automatic Calibration and Application for the Intelligent Medical Instrument
Zhirong XU ; Yi ZHU ; Xingyun RUAN
Chinese Medical Equipment Journal 2009;30(7):104-105
The intelligent level of the modern medical equipments is higher than before and the automatic calibration circuits are largely used. The control circuit of the intelligent equipments is quite complicated and its working modes have been simplified to four-terminal or double terminal nets. The intelligent medical equipments such as CT, MRI, DR, PET/ CT have more chances to have some "soft" errors that are usually related to the zero-line calibration. In actual use, it can be noticed and performed, and the detecting and servicing for the medical equipments can be much easier than before.
2.Clinical study of plasma exchange in the treatment of refractory idiopathic thrombocytopenic purpur with 2∶2∶1 exchange liquid.
Linhai RUAN ; Zhongqiao YUAN ; Yi XIE
Clinical Medicine of China 2001;0(06):-
Objective To study the effect of the plasma exchange in the treatment of RITP with 2∶2∶1 exchange liquid.Methods 32 cases of RITP were treated with plasma exchange using CS 3000 blood cell separator.Results Plasma exchange could reduce the levels of harmful substances like PA Ig,PA C 3,CIC and raise the levels of platelet by 3 times.Conclusion Plasma exchange is effective in the treatment of RITP with 2∶2∶1 exchange liquid,with reliable outcome.
3.The loss of heterozygosity on chromosome 3 of plasma free DNA of small cell lung cancer
Bin YI ; Heping YANG ; Zhihua RUAN ;
Journal of Third Military Medical University 1983;0(04):-
Objective To study the diagnostic and monitoring values of the loss of heteroxygosity(LOH) of 3p loci in free plasma DNA of small cell lung cancer. Methods PCR silver staining was used for the detection of LOH of three microsatellite sites in the 3p loci of plasma free DNA and tissue of SCLC. Results In 33 cases of tissue, the incidence rate of LOH was 54.5%(18/33), but the positive rate of LOH in plasma free DNA was 42.4%(14/33). The correlation between them was 78.8%(14/18). Conclusion The plasma free DNA in patients with lung cancer is primarily originated from the tumor tissue. LOH of plasma free DNA may be valuable molecular markers in the diagnosis of SCLC.
4.The significance of microsatellite analysis of plasma free DNA in diagnosis of lung cancer
Bin YI ; Heping YANG ; Zhihua RUAN ;
Journal of Third Military Medical University 1988;0(05):-
Objective To study the diagnostic value of LOH and MSI of free DNA 3p microsatellite point in plasma of lung cancer patients. Methods Using PCR and sliver dye techniques, LOH and MSI of three microsatellite sites of plasma DNA on chromosome 3p in resected fresh tissue from 37 patients and whole blood sample from 94 patients were detected. Results The plasma free DNA concentration of most lung cancer patients was above microgramme level. Above 70% of tissues and plasma were positive. No significant difference was found at different stages and in different pathologic types. The result of patients with lymph node metastasis was significantly different from that of the patients without lymph node metastasis. Conclusion Plasma DNA of lung cancer patients is a good medium for gene diagnosis and may be used widely in the future.
6.A comparison of surface electromyographic signals recorded from the paraspinal muscles of adolescents with idiopathic scoliosis during three loading tests
Chuhuai WANG ; Yi XU ; Qi LIANG ; Jingwen RUAN ; Jianyang LAI
Chinese Journal of Physical Medicine and Rehabilitation 2009;31(11):753-755
Objective Using surface electromyography (sEMG) techniques to investigate the patterns of frequency domain indexes of sEMC signals recorded from adolescent idiopathic scoliosis (AIS) patients' paraspinal muscles. Methods Twenty-five AIS patients were enrolled. All the patients undertook the Biering Sorensen test ( BST) ,the object-lifting test and a semi-bridge test, the ME3000P sEMG instrument was applied to record the electric activities of paraspinal muscles (convex/concave) of all subjects, and the time domain indexes such as averaged EMG(AEMG)and spectrum area(SPA) were analyzed, values in three tests were compared with one way ANOVA. Results The differences of AEMGs and SPAs on both convex and concave sides among the three tests showed no statistical significances (P = 0. 10,0.23, 0. 24 and 0. 45, respectively). Conclusions Any of the Biering Sorensen test( BST) , the object-lifting test or the semi-bridge test can be used to test the electric activities of paraspinal muscles (convex/concave) of AIS patients.
8.Antimicrobial prophylaxis in the prevention of incisional infection after tension-free inguinal hernioplasty: a meta-analysia
Yong WANG ; Jingjing ZHANG ; Yan CAO ; Yang WU ; Yi RUAN
Chinese Journal of General Surgery 2013;(6):460-463
Objective We conducted a systematic review and meta-analysis of the published literature to evaluate the efficacy of prophylactic antibiotics in the prevention of incisional infection of inguinal tension-free hernioplasty.Methods Articles of randomized controlled trials about the efficacy of prophylactic antibiotics in the prevention of incisional infection in the inguinal tension-free hernioplasty published from January 1975 to October 2012 was retrieved and systematically reviewed.Results A total of 11 randomized controlled trials meeting the inclusion criteria were screened.Among the 4159 cases of patients,130 cases had wound infection,and the infection rate was 3.13%.In the prophylactic antibiotics group of 1845 cases,wound infection occurred in 45 cases; the infection rate was 1.94%.In the control group of 2314 cases,85 cases had incision infection; the infection rate was 3.67%.The preventive use of antimicrobial drugs reduced surgical site infection of inguinal tension-free hernioplasty (OR 0.55,95% CI 0.38-0.80,P =0.002).Conclusions The use of prophylactic antibiotics can effectively reduce the incisional infection in the inguinal tension-free hernioplasty.
9.A Relevant Research on Changes in Characteristics of N-glycan in Gastric Cancer and Its Relationship with TCM Syndromes
Weixing ZHANG ; Yi RUAN ; Qunhao GU ; Jianpeng JIAO ; Long LIU
Chinese Journal of Information on Traditional Chinese Medicine 2014;(9):36-39,40
ObjectiveTo discuss the changes in characteristics of N-glycan in gastric cancer and its relationship with TCM syndromes.Methods The blood samples of 138 gastric cancer patients and 120 healthy volunteers were collected. The changes in N-glycan were detected by DNA sequencer-assisted and fluorophore-assisted carbohydrate electrophoresis (DSA-FACE), and differences of N-glycan among different TCM syndromes were compared.Results At least 9 N-glycan peaks could be identified in all samples. Compared with the healthy volunteers, Peak1, Peak5, Peak9 and Peak2 of gastric cancer patients obviously increased (P<0.05,P<0.01), whereas Peak3, Peak6 significantly decreased (P<0.01). Peak6 of gastric cancer in stage I was obviously higher than stages II, III, and IV (P<0.01), while Peak9 in stage I was obviously lower than the other three stages (P<0.01). Peak1 was significantly lower in disharmony between liver and stomach type than stagnation of phlegm-dampness type, interior retention of toxin stagnation type, deficiency of both Qi and blood type (P<0.05,P<0.01);lower in impairment of yin due to stomach heat type, deficiency-cold in spleen and stomach type than deficiency of both Qi and blood type (P<0.01);lower in stagnation of phlegm-dampness type, interior retention of toxin stagnation type than deficiency of both Qi and blood type (P<0.05). Peak6 was higher in disharmony between liver and stomach type than impairment of yin due to stomach heat type, stagnation of phlegm-dampness type, interior retention of toxin stagnation type than deficiency of both Qi and blood type (P<0.01). Peak9 was much higher in deficiency of both Qi and blood type than disharmony between liver and stomach type (P<0.01), impairment of yin due to stomach heat type and deficiency-cold in spleen and stomach type (P<0.05, P<0.01).Conclusion The expression of N-glycan was specifically changed in gastric cancer. These variations could promote the metastasis of gastric cancer and potentially have certain correlation with TCM syndromes.
10.Achievement of science and technology innovation mode study-Evaluation of the effectiveness of taking medicine as the example
Xueyuan YI ; Weihua LIU ; Yun PENG ; Peng RUAN
Chinese Journal of Medical Science Research Management 2016;29(2):113-119,124
The current evaluation for scientific and technological achievements and innovation is mainly based on novelty retrieval report conducted by professional organizations.However, such retrieval could not measure the actual value of a scientific and technological achievements comprehensively, such as the practicality and economic value of the outcome;and possibility to be adopted by industry, etc.Current study, from the application aspective, was trying to evaluate the scientific and technological achievements using effectiveness appraisal theory, which emphasis on pre-ethical assessment, demand and adoption assessment, and economic value assessment.It reveals the special phenomenon that that the outcome of innovation may decay over time, however, the effectiveness of innovation would enhance over time.This study also designed a mathematical model and the empirical use.