A study on 128 patients with ages of 2 and above indicated the blood and blood product transfussion in the pediatric department of the Hue Central hospital during 11/1998-12/199 has shown that the hematologic diseases were most frequent in which bone marrow failure: 26.6% and leukemia: 20.3%. The anemia related diseases are out hematopoietic system were the nephrotic syndrome:11.8% and malnutrition: 11.1%. The ratio of blood group O transfussed was highest in the total blood transfussion. The blood group B was highest rate in the hematocyte transfussion. The blood group A was highest rate in the serum transfussion.
Intubation, Intratracheal ; rocuronium ; surgery

BACKGROUND: This study compared the onset of action of Rocuronium given as single bolus versus divided dosing, using Propofol as an induction agent. The intubating conditions and hemodynamic changes accompanying laryngoscopy and tracheal intubation were assessed following the induction techniques. METHODS: Forty ASA I and II patients who underwent elective surgical procedures under general endotracheal anesthesia, aged 15 to 65 years old and categorized under Mallampati classifications I and II were included. They were randomly assigned to two groups. For Group A intubation sequence was Rocuronium 0.6 mg./kg., Propofol 2 mgs./kg., then 5 m1s. of plain isotonic solution. Group B sequence was: Rocuronium 0.4 mg./kg., Propofol 2 mgs./kg., then Rocuronium 0.2 mg./kg. Single twitch stimulation and train-of-four were used to monitor the onset time and intubation time. Statistical analysis was done by descriptive statistics and paired students T-test with a P-value0.05 considered significant RESULTS: Onset time and intubation time for the group given a divide dose of Rocuronium were shorter. No significant change in mean arterial pressures was seen in both groups, although there was an increase in cardiac rate for the group given a single bolus. CONCLUSION: The combination of Propofol and Rocuronium in divided dose is ideal for rapid sequence intubation.
Human ; Aged ; Middle Aged ; Adult ; Young Adult ; Adolescent ; HEMODYNAMICS ; LARYNGOSCOPY ; INTUBATION ; TRACHEAL, ANESTHESIA ; ROCURONIUM ; PROPOFOL

Purpose: Succinylcholine has been the agent of choice when clinical conditions require emergency airway protection during a rapid-sequence induction of anesthesia. However, the administration of succinylcholine is not without its problems. One of its side effects is the occurrence of fasciculations. To prevent fasciculations, a nonparalyzing dose of a nondepolarizing neuromuscular-blocking drug (pretreatment) is given prior to the actual administration of succinylcholine. Atracurium is one of the most popular nondepolarizing muscle relaxants used for pretreatment. Rocuronium is a novel non depolarizing muscle relaxant, that has a promising potential as a pretreatment drug. The objective of this trial was to determine the efficacy of rocuronium as a pretreatment drug and compare it with atracurium and placebo. Methods: Sixty ASA I and II patients about to undergo an emergency operation under rapid sequence induction of general anesthesia patients were enrolled in this double blind study. They were randomly divided into 3 groups of 20 according to the nondepolarizing pretreatment to be used: 0.9 percent NaCl (control), 0.05 mg/kg atracurium and 0.06 mg/kg rocuronium. Two minutes after pretreatment, succinylcholine at 1.5 mg/kg was injected. The presence and magnitude of fasciculations and the ease of tracheal intubation were assessed. Results: There was no difference among the three groups with respect to age, sex distribution and weight. Fasciculations occurred in 42 (70 percent) out of the 60 patients: 9 (45 percent) in the rocuronium group, 13 (65 percent) in the atracurium group and 20 (100 percent) in the saline group, P0.05. The severity of fasciculations was significantly lowest in the rocuronium group, followed by the atracurium group, and was highest with the saline or control group. Intubating conditions were rated as excellent, good, fair or poor in all patients. There was no statistically significant difference among groups. Conclusion: Rocuronium is superior to atracurium in preventing and reducing the intensity of fasciculations induced by succinylcholine, with no difference in the intubating conditions. Its use therefore in rapid-sequence induction of anesthesia as pretreatment is highly recommended, because it facilitates immediate airway intubation devoid of fasciculations and its undesirable effects. (Author)
Human ; Male ; Female ; Middle Aged ; Adult ; Young Adult ; Adolescent ; FASCICULATIONS ; ROCURONIUM ; ATRACURIUM ; SUCCINYLCHOLINE ; ANESTHESIA, GENERAL ; INTUBATION

OBJECTIVE: Robot-assisted radical prostatectomy (RARP) requires pneumoperitoneum (Pnp) and a steep head-down position that may disturb respiratory system compliance (C_rs) during surgery. Our aim was to compare the effects of different degrees of neuromuscular block (NMB) on C_rs with the same Pnp pressure during RARP. METHODS: One hundred patients who underwent RARP were enrolled and randomly allocated to a deep or moderate NMB group with 50 patients in each group. Rocuronium was administered to both groups: in the moderate NMB group to maintain 1-2 responses to train-of-four (TOF) stimulation; and in the deep NMB group to maintain no response to TOF stimulation and 1-2 responses in the post-tetanic count. Pnp pressure in both groups was 10 mmHg (1 mmHg=133.3 Pa). Peak inspiratory pressure (P_peak), mean pressure (P_mean), C_rs, and airway resistance (R_aw) were recorded after anesthesia induction and at 0, 30, 60, and 90 min of Pnp and post-Pnp. Surgical space conditions were evaluated after the procedure on a 4-point scale. RESULTS: Immediately after the Pnp, P_peak, P_mean, and R_aw significantly increased, while C_rs decreased and persisted during Pnp in both groups. The results did not significantly differ between the two groups at any of the time points. There was no difference in surgical space conditions between groups. Body movements occurred in 14 cases in the moderate NMB group and in one case in the deep NMB group, and all occurred during obturator lymphadenectomy. A significant difference between the two groups was observed. CONCLUSIONS Under the same Pnp pressure in RARP, deep and moderate NMBs resulted in similar changes in C_rs, and in other respiratory mechanics and surgical space conditions. However, deep NMB significantly reduced body movements during surgery.
Aged ; Humans ; Laparoscopy/methods* ; Lung Compliance/physiology* ; Male ; Neuromuscular Blockade ; Prostatectomy/methods* ; Respiratory Mechanics ; Robotic Surgical Procedures/methods* ; Rocuronium/pharmacology*

Objective To investigate diabetes-mediated changes in the neuromuscular pharmacodynamics of rocuronium in rats. Methods Diabetes mellitus was induced by a single injection of streptozotocin in rats.A total of 24 male SD rats were assigned to four groups using random number table:the normal control group,diabetic 2-week group,diabetic 4-week group,and diabetic 8-week group(6 rats per group).The sciatic nerve was stimulated in a rain-of-four(TOF)pattern,and the twitch tension changes in the tibialis anterior muscle were demonstrated by mechanomyography after intravenous injection of rocuronium in vivo.The time course characteristics of rocuronium,including onset time,and the recovery time from rocuronium injection to TOF ratio 75%(RT75%)and 90%(RT90%),were recorded,and half maximal inhibitory concentration(IC)values of rocuronium were determined using a four-parameter dose response curve. Results Compared with the normal controls,the diabetic rats had significantly prolonged onset time of rocuronium,while the RT75% and RT90% were decreased at all rocuronium doses(P<0.001).The time course changes became increasingly significant as the duration of diabetes lengthened(P<0.001).The IC and 95% confidence interval values for rocuronium in the normal control group,diabetic 2-week group,diabetic 4-week group,and diabetic 8-week group were 0.37(0.35-0.38)mg/kg,0.44(0.43-0.46)mg/kg,0.59(0.57-0.61)mg/kg,and 0.64(0.61-0.66)mg/kg,respectively.IC values were significantly higher in the diabetic groups vs.normal control(P<0.001)and gradually increased as the duration of diabetes lengthened(P<0.001).Conclusion Diabetes is associated with the rat skeletal muscle hyposensitivity to rocuronium,which is featured by prolonged onset time of rocuronium,decreased RT 75% and RT 90%,and right shift of the cumulative dose-response curve of rocuronium.
Animals ; Diabetes Mellitus, Experimental ; physiopathology ; Male ; Muscle, Skeletal ; drug effects ; Neuromuscular Nondepolarizing Agents ; pharmacology ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; Rocuronium ; pharmacology

BACKGROUND: The ease and rapidity of endotracheal incubation depends highly on the degree of muscle relaxation. The tracheal intubating conditions following equipotent doses of rocuronium, succinylcholine and vecuronium under general anesthesia with halothane, oxygen and nitrous oxide were studied and evaluated in ninety patients undergoing surgery. METHODOLOGY: Ninety patients, ASA 1-2, were randomly allocated to three groups. Group A was designated to receive 0.6 mg/kg rocuronium intravenously (n=30), group B was designated to receive 1.0 mg/kg succinylcholine intravenously (n=30) and group C was designated to receive 0.1 mg/kg vecuronium intravenously (n=30). All patients were premedicated with nalbuphine and promethazine and received 5 mg/kg thiopental for induction of anesthesia. Sixty seconds after receiving a muscle relaxant, intubation of the trachea was attempted and intubating conditions were graded by the blinded observer. Constant neuromuscular function monitoring was made using a peripheral nerve stimulator. RESULTS: Intubating conditions, sixty seconds after administration of rocuronium were clinically acceptable and comparable with those observed after succinylcholine. Rocuronium produced good to excellent intubating conditions even in the presence of incomplete block of the adductor pollicis muscle. The lag and onset time of action are significantly faster than those of vecuronium. The duration of clinical relaxation with rocuronium is however similar to that of vecuronium. CONCLUSION: Rocuronium is a new intermediate acting non depolarizing muscle relaxant with a brief lag and onset time of action that offers good to excellent interesting conditions at 60 seconds comparable with that of succinylcholine. (Author)
Human ; Middle Aged ; Adult ; Young Adult ; Adolescent ; INTUBATION ; INTUBATION, INTRATRACHEAL ; HEART RATE ; BLOOD PRESSURE ; SUCCINYLCHOLINE ; VECURONIUM BROMIDE ; MUSCLE RELAXANTS, CENTRAL ; ROCURONIUM

OBJECTIVE: To explore the effectiveness and feasibility of dexamethasone combined with oxybuprocaine hydrochloride gel on the prevention of postoperative sore throat after nasal endoscopy. METHODS: In the study, 60 patients with American Society of Anesthesiologist (ASA) physical statuses Ⅰ to Ⅱ, aged 18 to 72 years, scheduled for elective nasal endoscope surgery under general anesthesia requiring endotracheal intubation were randomly divided into dexamethasone combined with oxybuprocaine hydrochloride gel group (G group, n=30) and control group (C group, n=30). The patients in the G group received dexamethasone 0.1 mg/kg before induction and the oxybuprocaine gel was applied to the endotracheal catheter cuff and the front end within 15 cm. The patients in the C group received the same dose of saline and the saline was applied to the endotracheal catheter cuff and the front end within 15 cm. Then, all the patients in the two groups received the same induction and anesthesia maintainance. The operation time, anesthesia time, emergence time, extubation time and departure time were recorded. The intraoperative infusion volume, blood loss volume, propofol, remifentanil, rocuronium dosage were also recorded. The adverse reactions such as intraoperative hypotension, bradycardia and postoperative agitation were recorded. The postoperative sore throat score was recorded at the end of operation and 4 h, 8 h, 12 h, and 24 h after operation. RESULTS: Compared with the C group, the emergence time [(8.4±3.9) min vs. (10.8±4.7) min], extubation time [(8.8±3.7) min vs. (11.9±4.8) min], and departure time [(20.0±5.3) min vs. (23.0±5.8) min] were significantly shorter, and the propofol dosage [(11.8±1.8) mg/kg vs. (15.9±4.6) mg/kg], remifentanil dosage [(10.9±4.7) μg/kg vs. (14.1±3.6) μg/kg] were significantly less in the G group, and there was no difference of rocuronium dosage in the two groups. Compared with the C group the incidence of intraoperative hypotension [10%(3/30) vs. 30%(9/30)], bradycardia [16.7%(5/30) vs. 20%(6/30)] and postoperative agitation [6.7%(2/30) vs. 23.3%(7/30)] were significantly lower in the C group. The postoperative sore throat score at the end of operation, 4 h, 8 h, 12 h and 24 h after operation in the G group were significantly lower than in the C group respectively [0 (0, 1) vs. 1 (1, 2), 0 (0, 0) vs. 1 (1, 2), 0 (0, 0) vs. 1 (1, 2), 0 (0, 0) vs. 1 (0.75, 1), 0 (0, 0) vs. 1 (0, 1)]. CONCLUSION Dexamethasone combined with oxybuprocaine hydrochloride gel was effective and feasible on the prevention of postoperative sore throat after nasal endoscopy.
Adolescent ; Adult ; Aged ; Bradycardia/drug therapy* ; Dexamethasone/therapeutic use* ; Endoscopy/adverse effects* ; Humans ; Hypotension/drug therapy* ; Intubation, Intratracheal/adverse effects* ; Middle Aged ; Pain/drug therapy* ; Pharyngitis/prevention & control* ; Postoperative Complications/prevention & control* ; Procaine/analogs & derivatives* ; Propofol ; Remifentanil ; Rocuronium ; Young Adult