Humans ; Lead ; urine ; Lead Poisoning ; diagnosis ; urine ; Spectrometry, Fluorescence ; methods ; Spectrophotometry, Atomic ; methods

With the appearance of new biological agents represented by infliximab,the medical therapy of crohns' disease has made breakthrough of progress.However,the controversial still remains about the use of infliximab during perioperative period in Crohn's disease patients.The aim of this article is to explore the influence of infliximab on postoperative complications in Crohn's disease patients.

Objective To investigate the clinical outcomes of patients with chronic hepatitis B and its influencing factors,and provide reference for the prognosis of patients with hepatitis B.Methods 102 patients with chronic hepatitis B from January 2009 to June 2014 were selected and divided into the case group of 32 patients and the control group of 70 patients according to whether to occur with cirrhosis or liver cancer.The two groups of patients were analyzed and compared for general information,HBV DNA,serum ALT and other indicators.Results The cumulative cases of negative HBsAg,chronical hepatitis B,liver cirrhosis and liver cancer were 5,65 and 32,respectively.Univariate Logistic regression analysis showed that the differences between the two groups in age,sex,drinking history,HBV DNA levels and serum ALT levels were statistically significant (all P ＜ 0.05).Whether to cirrhosis or liver cancer was the dependent variable,the statistically significant single factors between the two groups were the independent variable,multivariate Logistic regression analysis showed that older age,male sex,alcohol abuse,high level of HBV DNA and high level of serum ALT were the risk factors of leading to cirrhosis,liver cancer for the patients with chronic hepatitis B (OR values were 9.94,14.36,8.25,13.01,120.32,respectively).Conclusions The older age,male,alcohol history,high level of HBV DNA and high level of serum ALT are higher risk factors for patients with chronic hepatitis B to development of cirrhosis and liver cancer.Patients with risk factors should be gave systematic interventions to reduce progression to cirrhosis,liver cancer and improve the quality of life.

Genetic Therapy ; Hepatitis B ; therapy ; Hepatitis C ; therapy ; Humans ; RNA Interference ; RNA, Small Interfering ; genetics ; RNA-Induced Silencing Complex ; genetics

Periodicals as Topic

Climacteric ; Drug Therapy, Combination ; Drugs, Chinese Herbal ; therapeutic use ; Female ; Humans ; Hyperthyroidism ; drug therapy ; Methimazole ; therapeutic use ; Middle Aged ; Phytotherapy

China ; Humans ; Liver Diseases

Enterovirus 71 infection was the most important agent related to severe and fatal cases of hand,foot and mouth disease in children. Some severe and fatal cases had cardiovascular dysfunction, which extremely possibly caused by central nervous system involvement and lesions with EV71 infection. But the mechanism was complex and unclear. Monitoring circulation condition and hemodynamic parameters, assessing cardiac function carefully were helpful to detect children at risk of cardiovascular involvement and dysfunction. Early recognition and intervention of children at risk of cardiovascular disorder is the key to rescue severe cases and reduce the mortality.

Objective To explore the effects of sequential nursing care on patient- ventilator inter-action after cardiovascular surgical procedure. Methods thirty-six patients after cardiovascular surgical procedure in ICU from July 2006 to July 2007 were enrolled, they were randomly divided into the experi-mental group and the control group with 18 patients in each group.The experimental group adopted sequen-tial nursing care, while the control group received conventional nursing care. The condition of patient- venti-lator interaction after cardiovascular surgical procedure was observed and underwent t test. Results Gen-erally, there were significant differences in inspiratory trigger pressure(P-T), inspiratory delay time(D-I), inspiratory trigger time (D-T). The index of arterial blood gas at 4,8,12 hours after patients regain con-sciousness completely was better and the time of mechanical ventilation after operation,the time of ward-ship,the hospi-tal stay time were also significantly shorter in the experimental group than those in the con-trol group. Conclusions The patient-ventilator counteraction can be reduced,and the patient-ventilator synchreny can be alleviated by sequential nursing care.

Objective To observe clinical effects of treming duodenal ulcer with rebeprazole combined with ulcer powder.Methods 78 cases patients with duodenal ulcer were randomly divided into a control group and a treatment group.The control group was treated wlth omeprazole,and the treatment group was treated with rebeprazole combined with ulcer powder.Thetherapeutic effects and adverse reaction were observed in both groups.Ayear's follow-up was performed after the treatment to observe ulcer recurrence rate of the two groups.Results The therapeutic effects of the treatment group were significantly better than the control group,and adverse reaction and ulcer recurrence rate of the treatment group were markedly lower than the control group.Conclusion The therapy of rebeprazole combined with ulcer powder has better effect in treating patients with duodenal ulcer than omeprazole.