Objective To evaluate the clinical application significance of the direct drug susceptibility test and the conventional drug susceptibility test in blood bacterial infection .Methods 280 specimens of positive blood culture in our hospital from March 2012 to April 2014 were randomly selected and performed the the direct drug susceptibility test and the conventional drug suscepti‐bility test .The correlation of the bacterial identification results and the drug susceptibility test results between these two kinds of method was investigated .Results The consistence of the direct bacterial identification method and bacterial identification method was 92 .5% ,the consistence rate of sensitivity ,drug resistance and moderate sensitivity had no statistical differences between the two kinds of method (P>0 .05) .Conclusion The direct drug susceptibility test can shorten the report time of blood culture posi‐tive specimen and effectively guide the rational use of antibiotics in clinic .

Objective To investigate the diagnostic value of procalcitonin(PCT) ,high‐sensitivity C‐reactive protein(hs‐CRP) andwhitebloodcelltestsinpatientswithbrucellosis.Methods 37blood‐culturepositivepatientsweredividedinto4groupsac‐cording to the species of bacteria infected .In addition to that ,PCT ,hs‐CRP and white blood cell were tested and the tests results were compared .Results The PCT and hs‐CRP concentrations of the 4 groups all increased and while the increasing extent of bru‐cella group were lower than the other 3 groups ,the differences were statistically significant(P<0 .05) .The counting of white blood cell(WBC) ,neutrophil(NEUT) and lymphocyte(LYMPH) were all in normal range while the monocyte(MONO) raised to 80 .0%in brucella group .WBC and NEUT apparently were higher in the other 3 groups than in brucella group ,while LYMPH and MONO were lower than brucella group ,the differences were statistically significant(P<0 .05) .Conclusion The determinations of PCT ,hs‐CRP and white blood cell may act as the indicators for early stage of brucellosis .

Objective To investigate the change of high‐sensitivity C‐reactive protein(hs‐CRP) and white blood cell(WBC) in patients with positive sputum culture results .Methods hs‐CRP and WBC were determined in 116 patients with positive sputum culture results ,which were divided into 5 groups according to strains ,and control group of patients with negative sputum culture re‐sults .Levels and abnormal rates of various parameters were compared between each group .Results hs‐CRP levels significantly in‐creased in the 5 sputum culture positive groups ,compared with control group(P<0 .05) ,and that of Candida albicans group was the most high .WBC and neutrophile granulocyte(NEU) levels of 4 positive groups were obviously raised(P<0 .05) besides Haemophi‐lus influenzae group ,and the elevation tendency was the most obvious in Streptococcus pneumoniae group .The 5 positive groups were all with high detectable rates of hs‐CRP elevation .The detectable rate of WBC elevation in Streptococcus pneumoniae group was 64 .7% ,higher than Haemophilus influenzae group(P<0 .05) .Conclusion The majority of patients with positive sputum cul‐ture results could be with inflammatory response because of bacterial infection or colonization .