Objective To investigate the current infection situation of Chlamydia trachomatis (CT) and Ureaplasma urealyticum (Uu) in patients with cervical erosion .Methods CT and Uu were detected in cervical secretions of 562 cases of cervical erosion pa‐tients (observation group) and 218 healthy controls (control group) .Drug susceptibility testing was performed for the patients with Uu infection .Results Positive rate of CT ,Uu and mixed infection was 20 .11% ,42 .35% and 9 .61% ,higher than those of control group (P<0 .05) .The difference of the positive rate between moderate cervical erosion and severe cervical erosion was not signifi‐cant (P>0 .05) ,while the positive rate of CT ,Uu and mixed infection was significantly different between the two groups and mild cervical erosion (P<0 .05) .The highest susceptibility rate of Uu to antimicrobial agents was josamycin (91 .78% ) ,followed by pristinamycin (84 .25% ) .The highest resistant rate of Uu was to ciprofloxacin (85 .96% ) ,followed by ofloxacin(73 .29% ) .Conclu‐sion The infection of CT and Uu could be intimate correlated with cervical erosion and the extent of erosion .Varying degrees of drug resistance of Uu could be found ,and the sensitive and effective antibiotics should be chosen to treat cervical erosion infection of Uu .