OBJECTIVE:To investigate the new management model of the hospital pharmacy established by application of vender managed inventory (VMI) model. METHODS:Concerned about the implementation of VMI model,its effects and prob-lems,new management model of hospital pharmacy were described after the hospital cooperated with two suppliers. The hospital is mainly in charge of the management and application of pharmaceutical staff and equipment,drug capital flow,and the selection and optimization of drug use list;focus on the training of pharmaceutical talents;improve drug quality management,pharmaceuti-cal administration,pharmaceutical care and rational drug use. Two suppliers are mainly in charge of drug logistics,and the alloca-tion of servicer,software and hardware(as automatic medicine dispensing machine);share logistic cost of supply chain. Drug in-formation flow was established by both hospital and supplier. RESULTS:After cooperation,pharmaceutical staff,related equip-ment and inventory cost(floating capital decreased by 10 million yuan each month)were decreased,and the efficiency of distribu-tion improved;the error rate of drug dispensing in outpatient pharmacy were decreased (decreasing from 0.39‰ to 0.12‰) after the establishment of automatic pharmacy. The establishment of early warning system for abnormal patients flowrate in pharmacy window shortened the time of getting medicine,and improved service level and satisfactory degree of patients (increasing from 84.91% to 93.62%). CONCLUSIONS:New management model of hospital pharmacy based on VMI model provides reference for public hospital reform and hospital-enterprise cooperation under New Medical Reform.

Objective This study was to evaluate the usefulness of the model of end-stage liver disease (MELD) score in comparison with the Child-Pugh classification to predict postoperative mortality and short-term survival in liver transplant patients. MethodsMELD score and Child-Pugh score were computed for each patient according to the original formula on admission day. Kaplan-Meier survival curves were made using the cut-off points calculated by Youden index. ResultsSix out of 40 patients died within three months, MELD scores and Child-Pugh scores for non-survivors (32.2?8.0, 12.3?2.0) were higher than those for survivors (13.4?6, 9.12?2.31) significantly (P

Objective:To understand the diagnostic value of tuberculosis (TB) pathogenic detection methods (TPDM) in pathological tissue for TB.Methods:A retrospective study was conducted with 190 pathological specimens from different tissues suspected with TB from Third People′s Hospital of Shenzhen during May 2016 and May 2019. Specimens were divided into four groups according to histomorphology: group one, necrotizing granulomatous inflammation (109 cases); group two, non-necrotic granulomatous inflammation (20 cases); group three, non-granulomatous inflammation (45 cases); group four, non-tuberculous lesions (16 cases). The positive rates of each TPDM among specimens from four groups were compared. The positive rates of all TPDM for specimens from group one were compared. Meanwhile, the influence of antituberculosis treatment course on the TPDM was analyzed. Chi-square test or Fisher′s exact test was used for statistical analysis.Results:The positive rates of Ziehl-Neelsen acid-fast staining among the four groups were 17.4%(19/109), 5.0%(1/20), 4.4%(2/45) and 0(0/16), respectively. The positive rates of Mycobacterium tuberculosis (MTB) complex culture were 32.0%(32/100), 4/19, 4.8%(2/42) and 0(0/16), respectively. The positive rates of Mycobacterium tuberculosis/rifampin resistance real-time quantitative nucleic acid amplification detection system (Xpert MTB/RIF) were 74.3%(81/109), 15.0%(3/20), 13.3%(6/45) and 0(0/16), respectively. The positive rates of fluorescent quantitative polymerase chain reaction (FQ-PCR) were 63.0%(58/92), 0(0/15), 2.6%(1/38) and 0(0/10), respectively. The positive rates of simultaneous amplification and testing (SAT) were 32.4%(24/74), 0(0/10), 0(0/15) and 0(0/10), respectively. The differences of each TPDM among four groups were all statistically significant (all P<0.05). The positive rate of Xpert MTB/RIF in group one specimens was significantly higher than those of acid-fast staining, MTB culture and SAT ( χ2=71.016, 37.162 and 35.679, respectively, all P<0.01), while the difference was not statistically significant when compared with FQ-PCR ( χ2=2.517, P=0.112). The positive rate of combined TPDM (85.3%(93/109)) was significantly higher than Xpert MTB/RIF(74.3%(81/109)) ( χ2=4.100, P=0.043). The positive rates of acid-fast staining group 1A (anti-tuberculosis treatment course was less than one month) and group 1B (anti-tuberculosis treatment course was longer than one month) were 14.3%(7/49) and 20.0% (12/60), respectively ( χ2=0.612, P=0.434); those of MTB culture were 48.9% (22/45) and 18.2% (10/55), respectively ( χ2=10.721, P=0.001); those of Xpert MTB/RIF were 69.4%(34/49) and 78.3%(47/60), respectively ( χ2=1.131, P=0.287); those of FQ-PCR were 55.0%(22/40) and 69.2%(36/52), respectively ( χ2=1.965, P=0.161); those of SAT were 43.3%(13/30) and 25.0%(11/44), respectively ( χ2=2.736, P=0.098). Conclusions:The results of TPDM correlate closely with the typical histomorphological features of tuberculosis. Xpert MTB/RIF possesses significantly higher sensitivity than any other single TPDM, and is not attenuated by early anti-tuberculosis treatment. Combined TPDM could significantly improve the sensitivity of TB pathogenic detection, which is suggested to be applied when the tissue specimen is sufficient.

Objective:To investigate the current status of early pain in patients after total knee arthro-plasty under enhanced recovery mode and analyze the influencing factors.Methods:In the study,142 patients with total knee arthroplasty of a hospital in Beijing were investigated by convenient sampling.Visual analog scale(VAS)was used to describe the degree of pain(including resting pain and activity pain)within 3 days after operation,and the nature and location of pain and satisfaction with the analgesic effect of the patients were recorded.The influencing factors included age,gender,place of residence,education level,body mass index(BMI),years of pain,chronic medical history,surgical history,surgi-cal duration,whether to indwell a drainage tube,type of carer,severity of the disease,sleep quality,anxiety,depression,and preoperative pain level.The investigation tools of influencing factors were the general information questionnaire of patients,pain assessment questionnaire,Pittsburgh sleep quality index(PSQI),self-rating anxiety scale(SAS)and self-rating depression scale(SDS).Firstly,single factor analysis was carried out on the included influencing factors,and then multiple stepwise regression analysis was carried out on the statistically significant variables to clarify the main influencing factors of early pain in patients after total knee arthroplasty.Results:The peak pain of the patient occurred at night on the first postoperative day and in the afternoon on the second postoperative day,with resting pain scores of(2.5±1.2)and(2.7±1.1),and activity pain scores of(3.8±1.5)and(4.0±1.6);the most common pain site was posterior knee pain(68,47.9％),followed by anterior knee combined with posterior knee pain(32,22.5％),anterior knee pain(27,19.1％),anterior knee combined with me-dial knee pain(10,7.0％),and anterior knee combined with lateral knee pain(5,3.5％);the nature of pain was mostly composed of soreness combined with swelling pain(58,40.8％),while the rest in-cluded simple soreness(26,18.3％),simple swelling pain(24,16.9％),hot burning pain(10,7.0％),pricking pain(9,6.3％),spasmodic traction pain(5,3.5％),tearing pain(4,2.8％),knife cutting pain(3,2.2％),and stabbing pain combined with soreness(3,2.2％);the patients who were satisfied and very satisfied with the analgesic effect were 114(80.3％).The results of univariate analysis showed that there were significant differences in sleep quality,disease severity,types of care-givers and depression score(P＜0.05).The results of multiple stepwise regression analysis showed that the main factors affecting the patients'early postoperative pain were preoperative sleep quality,depres-sion,the Knee Society score and the type of care(P=0.002).Conclusion:Most patients under en-hanced recovery after surgery are satisfied with the effect of pain control after operation.Medical staff can carry out predictive intervention in patients'sleep quality,depression to reduce the patients'early post-operative pain.At the same time,the research results suggest that choosing family members to accompany the patients can effectively improve the patients'early postoperative pain experience.