1.Study on Strengthening the Supply Chain Security Competency of Medical Consumables According to JCI
Hua YE ; Qunji CHEN ; Erliang HUANG
Chinese Hospital Management 2016;36(7):64-66
Objective To protect patients and employees from being polluted and the inferiors,and to build a prototype to enhance the supply chain security of medical consumables according to JCI.Method According to the supply chain security model,adopting corresponding measures of the design of the supply chain management of medical consumables.Result The supply chain security capabilities are enhanced and the risk is reduced in accordance with the quality requirements of JCI.Conclusion The security model applied in the supply chain management of medical consumables can effectively strengthen the security of the supply chain.
2.Effect of ligustrazine on pulmonary arterial pressure and pulmonary arterial wall collagen of chronic hypoxic hypercapnic rats
Zhijie GAO ; Liangxing WANG ; Qunji WANG ; Yupeng XIE ; Yanfan CHEN ; Shaoxian CHEN ; Wei WANG
Chinese Journal of Pathophysiology 1989;0(05):-
AIM: To study the effect of ligustrazine on pulmonary hypertensive rats induced by hypoxic hy- percapnia. METHODS: Thirty rats were randomly divided into three groups: control group(A), hypoxic hypercapnic group (B), hypoxic hypercapnia+ligustrazine (lig. ) group(C). RESULTS: (1) Mean pulmonary axterial pressure (mPAP)of group B was significantly higher than that of group A and mPAP of group C was significantly lower than that of group B(P0.05); (2)Electron microscopy and immunohistochemistry showed ligustrazing could inhibit the diposition of col- lagenous fiber(collagen type Ⅰ )in pulmonary arterioles induced by hypoxic hypercapnia; (3) Plasma endothelin level of group C was significantly lower than that of group B (P
3.Effects of Salvia miltiorrhiza Bge on left ventricular hypertrophy in spontaneously hypertensive rats and expression of c-fos
Junyan CHENG ; Zhongqiu LU ; Zhangping LI ; Shouquan CHEN ; Zhi ZHEN ; Qunji WANG
Chinese Journal of Clinical Pharmacology and Therapeutics 2004;0(07):-
AIM: To observe the effects of Salvia miltiorrhiza Bge (SMB) on left ventricular hypertrophy(LVH)in spontaneously hypertensive rats (SHR) and the expression of c-fos. METHODS: 18 SHRs in 8 weeks old were divided into three groups at random. SMB or distilled water(1 g?kg -1?d -1)was injected intraperitoneally to two groups for 10 weeks. Systolic blood pressure (SBP) and left ventricular mass index(LVMI)were measured. HE,VG and immunohistochemical staining combined with computed morphometry were used to evaluated the cardiomyocyte size and diameter, the collagen volume fraction(CVF), perivascular circumferential area (PVCA) and c-fos expression in the left ventricular tissue. RESULTS: Compared with 8-week-old rats, the SBP, LVMI, cardiomyocyte size and diameter, CVF, PCVA, c-fos expression increased markedly in the 18th week of SHRs. The LVH stopped and c-fos expression decreased whereas SBP changed slightly in animals treated with SMB. CONCLUSION: Chronic treatment with SMB can inhibit the development of LVH in SHR, which is probably related to the decease of cardiac c-fos.
4.Relationship between expression of heme oxygenase-1 mRNA and pulmonary hypertention induced by hypoxic hypercapnia
Xiaoying HUANG ; Liangxing WANG ; Shaoxian CHEN ; Zhengjie XU ; Qunji WANG ; Xiaofan FAN
Chinese Journal of Pathophysiology 1999;0(09):-
AIM: To study the effect of chronic hypoxic hypercapnia on expression of heme oxygenase-1(HO-1). METHODS: Sprague-Dawley rats were randomly divided into three groups: control group(A),hypoxic hypercapnic group(B), hypoxic hypercapnia+hemin group(C). HO-1 and HO-1 mRNA were observed in pulmonary arterioles by the technique of immunohistochemistry and in situ hybridization. RESULTS: ① mPAP and weight ratio of right ventricle(RV) to left ventricle plus septum (LV+S) were significantly higher in rats of B group than those of A and C group (P0.05). ② Blood CO concentration was significantly higher in rats of B group than that of A group(P
5.Effect of diltiazem on pulmonary arterial pressure and ceNOS mRNA expression in pulmonary arteries in chronic hypoxic hypercapnic rats
Liangxing WANG ; Shaoxian CHEN ; Zhengjie XU ; Linsheng YU ; Qunji WANG ; Yupeng XIE ; Yanfan CHEN ; Wei WANG ; Hongqin ZHANG
Chinese Journal of Pathophysiology 1999;0(09):-
AIM: To investigate the effect of diltiazem on mean pulmonary arterial pressure(mPAP) and nitric oxide synthase(NOS) in arterioles in chronic hypoxic hypercapnic rats. METHODS: Twenty-four rats were randomly divided into three groups: control group(A),hypoxic hypercapnic group(B), hypoxic hypercapnia+ diltiazem group (C), constitutive endothelial NOS(ceNOS) were observed in arterioles of rats using the technique of immunohistochemistry,ceNOS mRNA were observed by the technique of in situ hybridization . RESULTS: (1)mPAP was significantly higher in rats of B group than that of A and C group( P 0 05),but mCAP was lower in rats of C group than that in B group.(2)Light microscopy showed WA/TA (vessel wall area/total area) was significantly lower in rats of C group than that of B group ( P
6.Research on relationships of gastric cancer with serum trace elements, Helicobacter pylori and COX-2 in gastric tissue.
Yumin LI ; Qunji XUE ; Liren CHEN ; Hao CHEN ; Chen CHAI ; Bing SHI ; Yanming ZHOU
Journal of Biomedical Engineering 2004;21(1):107-110
The relationships of gastric cancer with serum trace elements, helicobacter pylori (HP) and COX-2 in gastric tissue were investigated. We took 50 blood samples from the gastric cancer patients in Hexi region (the gastric cancer group), and 50 blood samples from healthy volunteers (control group) and detected the level of trace elements, the rate of HP infection, and the expression of COX-2 in gastric tissue. The results showed the levels of Cu/Zn, Fe in the serum of the gastric cancer group were higher than those of the control group respectively(P < 0.05, 0.01), and the levels of Zn, Mn were lower than those of the control group respectively (P < 0.05, 0.01). The data on Zn were submitted to multi-variate non-conditional logistic analysis. The rate of HP infection and the positive expression of COX-2 were 88% and 78% respectively in the gastric cancer group, 42.0% and 0 in the control group (P < 0.01). These findings suggest that the decrease of Zn in serum may be a precancerous factor of gastric cancer development which induces HP infection and the higher expression of COX-2 and hence may lead to the development of gastric cancer. Detecting the trace elements could conduce to the diagnosis of gastric cancer. Regulating the level of trace element in the patient can be an effective chemoprophylaxis for gastric cancer.
Adult
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Case-Control Studies
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Cyclooxygenase 2
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metabolism
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Female
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Helicobacter Infections
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metabolism
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Helicobacter pylori
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Humans
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Logistic Models
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Male
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Middle Aged
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Risk Factors
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Stomach Neoplasms
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blood
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metabolism
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microbiology
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Trace Elements
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blood
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Zinc
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blood