Objective To access the efficacy of oximeter in blood oxygen saturation monitoring in limb fracture patients. Method Monitor the blood oxygen saturation level in 200 patients with limb fractures , and determine whether blood circulation disorders exist in these patients accordingly. Results Within the 200 patients, 107 had normal blood oxygen saturation level, 50 patients had possible blood circulation disorder , 40 patients had blood circulation disorder, 3 patients had critical limb ischemia among which 2 were diagnosed as osteofascial compartment syndrome , and one as partial breakage of arteriovenous vessels. All the patients recovered well after prompt and proper treatment. Conclusion Blood oxygen saturation monitoring in post-limb- fracture patients using a oximeter can discover blood circulation disorders promptly , thus ensure proper treatment and avoid mal-practice and missed diagnosis.

OBJECTIVE: To assess the association of single nucleotide polymorphisms (SNPs) of microRNA-146a (miR-146a) with clinical features of rheumatoid arthritis (RA). METHODS: In 126 patients with RA and 102 matched healthy controls, SNPs of miR-146a rs2910164 locus were determined with a high-resolution melting method. The association of such polymorphisms with disease activity score in 28 joints (DAS28) and clinical features of RA was assessed. RESULTS: The distribution of SNPs of miR-146a rs2910164 among RA patients did not differ from that of the control group. No significant association was found between miR-146a rs2910164 polymorphism with DAS28. However, RA patients with a GG genotype had a greater chance to develop extra-articular manifestations (P<0.01). CONCLUSION Polymorphisms of miR-146a rs2910164 locus is not an independent risk factor for RA, though its GG genotype may be associated with extra-articular manifestations of RA.
Arthritis, Rheumatoid ; genetics ; Case-Control Studies ; Genetic Predisposition to Disease ; Genotype ; Humans ; MicroRNAs ; genetics ; Polymorphism, Single Nucleotide