Objective To investigate the influence of early postoperative enteral nutrition on the immunologic function and inci-sion infection in the patients with colorectal cancer .Methods 81 postoperative cases of colorectal cancer were randomly divided into the early parenteral nutrition(41 cases) ,and the early enteral nutrition(40 cases) by the random number table method .The anal ex-haust time ,ambulation time and occurrence situation of incision infection ,etc .were compared between the two groups ,and the im-munological indexes changes were also compared .Results Postoperative anal exhaust time ,bed activity time and the occurrence rate of incision infection in the early enteral nutrition group were significantly lower than those in the early parenteral nutrition group (P<0 .05);Th1/Th2 and lymphocyte count in the early enteral nutrition group were significantly higher than those in the early parenteral nutrition group(P<0 .05) .Conclusion The early postoperative enteral nutrition support in the patients with colorectal cancer can effectively improve the body's immune function and is an ideal method of nutritional support .

OBJECTIVE:To investigate the effects of intensive insulin therapy on related indexes of stress diabetes patients with multiple trauma. METHODS:82 stress diabetes patients with multiple trauma were randomly divided into observation group and control group,with 41 cases in each group. Two groups were given specific processing. Observation group was additionally giv-en biosynthetic human insulin therapy with 1-2 IU/h drops of micro pump,adjusting dripping speed of micro pump according to re-al-time blood glucose value. Control group was given metformin hydrochloride tablets,with a meal,the initial dose of 0.5 g,twice a day,adjusting the dose of glucose-lowering drugs according to blood glucose value,increasing the dose to 1 g,twice a day. Both groups were treated for 10 d. CRP,TNF-α,IL-1,IL-6,average blood glucose were observed in 2 groups before and after treat-ment. The occurrence of complications as local infection,sepsis and SIRS were compared between 2 groups. RESULTS:After treat-ment,the serum levels of CRP,TNF-α,IL-1,IL-6,average blood glucose in 2 groups were significantly lower than before,and the serum level of CRP,IL-1,IL-6 in observation group after 5,10 d of treatment and the serum level of TNF-α,average blood glu-cose after 1,5,10 d of treatment was significantly lower than control group at same time,with statistical significance(P<0.05). The incidence of complications in observation group after multiple trauma was significantly lower than control group,with statisti-cal significance (P<0.05). No obvious ADR was found in 2 groups during treatment. CONCLUSIONS:Based on routine treat-ment,intensive insulin therapy can more effectively reduce the levels of blood glucose and inflammatory factors and prevent the oc-currence of complications after multiple trauma,moreover,do not increase the occurrence of ADR.

OBJECTIVE:To observe the safety and therapeutic efficacy of low molecular weight heparin calcium in the preven-tion of venous thromboembolism (VTE) of ICU patients. METHODS:572 VTE patients were randomly divided into trial group and control group,with 286 cases in each group. Trial group was given Low molecular weight heparin calcium injection 0.3-0.6 ml, im,qd;control group was given Rivaroxaban tablet 10 mg,po,qd. The incidence of VTE,platelet count,coagulation function, quality score of life and the occurrence of ADR were compared between 2 groups. RESULTS:The incidence of VTE in trial group (0.3%)was significantly lower than control group(2.1%),with statistical significance(P<0.05). There was no statistical signifi-cance in platelet count,prothrombin time,APPT, fibrinogen and other indexes between 2 groups before and after treatment(P>0.05). The physical health,body function and role,general health,emotional role function,mental health and other aspects of trial group were improved significantly,compared to control group,with statistical significance(P>0.05). No obvious ADR was found in 2 groups. CONCLUSIONS:Low molecular weight heparin calcium can effectively prevent VTE and improve the quality of life, while doesn’t influence platelet count and coagulation function with good safety.