Objective To discuss the diagnostic value of bone esoinophilic granuloma with CT and X-ray plain film.Methods The X-ray and CT manifestations of 39 patients with esoinophilic granuloma of bone confirmed by pathology were analysed retrospectively.Results Monofocal lesion was found in 22 cases(56.4%) and multifocal lesions were in 17 cases(43.6%).Monofocal lesion was most seen in skull 8 cases in this group(36.4%).The X-ray and CT manifestations of bone eosinophilic granuloma were varied with the site and pathologic process of lesion.Conclusion CT is better than plain film in demonstrating the internal components of bone eosinophilic granuloma,especially the button sequestrum and soft tissue mass in the lesion,but plain film examination still can't be replaced with CT scan.Plain film is still the primary method in diagnosis of eosinophilic granuloma of bone.