Objective To observe the effects of ACEI( enalapril) on expression of MMP-2 and MMP-9 in renal hypertension rats with focal cerebral ischemia-reperfusion injury. Methods Twenty-eight Wistar male rats were randomly divided into two groups: hypertension group and normaltension group. The former which formed model of renal hypertension rats by constricted renovascular were randomly divided into enalapril group (Y) and hypertension ischemia and reperfusion group(HIR),which fed with enalapril 2mg/kg and equal volum saline respectively;The latter were divided into sham-operation group ( N) and normaltension ischemia and reperfusion group (IR). The focal cerebral ischemia model was established in Wistar rats by using the method of thread inserting left middle cerebral artery occlusion(MCAO) for 2h. After ischemic 24h,the expression of MMP-2 and MMP-9 were measured by immunohisto-chemistry,and the gray scale value was measured by imaging analysis. Results Compared with N,the gray scale values of MMP-2 and MMP-9 in IR were higher(P <0. 01); Compared with IR, the gray scale values of MMP-2 and MMP-9 in HIR were higher(P<0. 05);Compared with HIR,the gray scale values of MMP-2 and MMP-9 in Y were lower(P<0.01). Conclusion Hypertension can increase the expression of MMP-2 and MMP-9 in rats with focal cerebral ischemia-reperfusion. ACEI (Enalapril) could inhibit the expression of MMP-2 and MMP-9 in renal hypertension rats with focal cerebral ischemia-reperfusion.

Objective To investigate the effect of health education on treatment compliance and the quality of life (QOL) in adult patients with epilepsy. Methods A total of 130 adults patients with epilepsy were assigned to the bealth-education group ( n = 68 ) and the non-health-education group ( n = 62 ). All participants received standard treatment. In the health-education group, instructions on epilepsy prevention and treatment and individual psychological counseling were given to the patients or theirs families for 6 months. Quality of life in epilepsy-31 ( QOLIE-31, Chinese version ) was used for evaluation. Results Knowing rate of epilepsy-related information in the health-education group (94. 12% ) was significantly higher than that in the non-health-education group (29.03%) (X2 = 58.99 ,P ＜ 0. 05 ) ; patients with non-standard treatment and experienced adjusted medication were significantly lower in the health-education group ( 10. 29% vs. 27.42%, and 27.94% vs. 45. 16%, respectively ) ( P ＜ 0. 05 ). At 3 and 6 months, the patients whose attack rate decreased ＞ 50% and had disease completely controlled in the health-education group (79.41% vs. 51.61%, 36.77% vs. 20.97%, 85.29% vs. 61.29%, 42.65% vs. 25.81%,respectively) were more than that in the non-health-education group. QOL scores were remarkablely increased after intervention in all the patients ( P ＜ 0. 05 ), especially in the health-education group ( P ＜ 0. 05 ).Conclusions More health education may be helpful in improving treatment comphance and QOL and reducing disease attack in epilepsy patients.

Objective To investigate the distribution of arterial stenosis in patients with ischemic cerebrovas-cular disease and its risk factors .Methods 224 patients with ischemic cerebrovascular disease were divided into four groups according to DSA results .Patients showed no stenosis or mild stenosis were selected as control group ( 43 ca-ses),the other patients were divided into pure extracranial stenosis group (41 cases),simple intracranial stenosis group (93 cases) and extracranial stenosis group (47 cases).The results of laboratory test were analyzed .The ques-tionnaire was designed and the indicators including name ,age,long-term smoking,drinking,hypertension and diabetes were collected .Results Of all the subjects , there were 181 cases with artery stenosis .Single factor results showed that gender,age,long-term smoking,long-term drinking,hypertension,diabetes,high homocysteine,high level of lyso-phosphatidic acid were the independent risk factors of cerebral artery stenosis (χ2/t =8.744, 5.562, 10.736, 11.032,9.812,10.002,9.083,2.576,all P<0.05).Multivariate analysis showed that high homocysteine ,long-term smoking and drinking were the risk factors of simple intracranial artery stenosis .High homocysteine and high fibrino-gen were risk factors of simple extracranial stenosis .Age,hypertension,long-term smoking and drinking ,high homocys-teine and fibrinogen were risk factors of intracranial and extracranial stenosis .Conclusion In patients with ischemic cerebrovascular diseases ,the simple intracranial artery stenosis is most common .The incidence of cerebral artery ste-nosis has age characteristic ,with the increase of age ,the incidence rate of intracranial and extracranial artery stenosis is rising.High homocysteine,long-term smoking and drinking,hypertension,diabetes,high lysophosphatidic acid are independent risk factors of cerebral artery stenosis .