Combined Modality Therapy ; Drugs, Chinese Herbal ; therapeutic use ; Humans ; Medicine, Chinese Traditional ; methods ; trends ; Neoplasms ; diagnosis ; drug therapy ; therapy ; Phytotherapy ; Treatment Outcome

Dosage Forms ; Drug Carriers ; Drug Delivery Systems ; Drugs, Chinese Herbal ; administration & dosage ; Humans ; Nanotechnology

Antineoplastic Agents, Phytogenic ; pharmacology ; therapeutic use ; Apoptosis ; drug effects ; Cyclin-Dependent Kinases ; metabolism ; Drugs, Chinese Herbal ; pharmacology ; therapeutic use ; Gene Expression ; drug effects ; Gene Expression Regulation, Neoplastic ; drug effects ; Humans ; Neoplasms ; drug therapy ; metabolism ; Protein-Tyrosine Kinases ; metabolism ; Signal Transduction

Animals ; Annexin A2 ; chemistry ; genetics ; metabolism ; physiology ; DNA Replication ; Endocytosis ; Exocytosis ; Humans ; Neoplasm Invasiveness ; Neoplasm Metastasis ; Neoplasms ; metabolism ; pathology ; Prognosis ; Tissue Plasminogen Activator ; metabolism ; physiology

In an effort to search for more potent antibacterial drugs, the minimum inhibitory concentrations (MIC) of fifteen fosfomycin derivatives at 35℃ for 24h against S. aureus, Enterococcus, P.aeruginosa and Eschericha coli were determined, respectively. Preliminary antibacterial results showed that five derivatives of them were more potent than reference substance (Ⅳa) against some bacteria. Take compound Ⅳg for example, its antibacterial activity was three times as potent as that of compound Ⅳa against S.aureus. The structure-activity relationship of fosfomycin derivatives was investigated according to the mechanism of fosfomycin antibacterial action at molecular level which was pointed by Smeyers et al.

Alkaloids ; pharmacology ; Angiogenesis Inhibitors ; pharmacology ; Antineoplastic Agents, Phytogenic ; pharmacology ; Drugs, Chinese Herbal ; chemistry ; Ginsenosides ; pharmacology ; Humans ; Lymphatic Metastasis ; prevention & control ; Pyrazines ; pharmacology ; Quinolizines

Acupuncture Therapy ; Adult ; Female ; Humans ; Sjogren's Syndrome ; therapy

Animals ; Antineoplastic Agents, Phytogenic ; blood ; pharmacology ; Apoptosis ; drug effects ; Breast Neoplasms ; pathology ; Humans ; Liver Neoplasms ; pathology ; Serum ; chemistry ; physiology ; Tumor Cells, Cultured

Purpose To investigate the value of 3.0T MR T1ρquantitative analysis in early detection of disc degeneration. Materials and Methods Conventional T2WI and T1ρwere collected in 35 healthy volunteers (male 16, female 19) on 3.0T MRI, and the classification of disc nucleus was performed by Pfirrmann classification. T1ρvalue of nucleus pulposus was measured and analyzed for the relationship among Pfirrmann classification, segmental and gender. Results There was a significant negative correlation between T1ρvalue and Pfirrmann grade (r=-0.542, P<0.001). T1ρvalue in L5/S1 segment (94.80±26.60) ms was significantly lower than that in L2/L3 (117.18±25.64) ms and L3/L4 (115.52±28.53) ms (P<0.01), and there was no significant difference among other segments (P>0.05);there was no gender differences among the T1ρvalue of each segment (t=0.006, 0.042, 0.797, 1.022, 0.038, P>0.05). Conclusion T1ρ value is closely related to the degree of disc degeneration, and T1ρimaging can be used as an objective, sensitive and effective tool for early detection of disc degeneration.

0.05) when all cases were put together. But the observed morbidity in group B (20%) was less than that in group A (40%) with the difference being statistically significant (?~2=4.41,P=0.036). ConclusionsThe POSSUM methodology allows satisfactory prediction of mortality and morbidity rates in patients undergoing colorectal tumor surgery.