4.Regulatory action of Chinese herbs on the signal transmission abnormality in oncogenesis.
Chinese Journal of Integrated Traditional and Western Medicine 2003;23(11):876-879
Antineoplastic Agents, Phytogenic
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pharmacology
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therapeutic use
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Apoptosis
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drug effects
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Cyclin-Dependent Kinases
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metabolism
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Drugs, Chinese Herbal
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pharmacology
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therapeutic use
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Gene Expression
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drug effects
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Gene Expression Regulation, Neoplastic
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drug effects
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Humans
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Neoplasms
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drug therapy
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metabolism
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Protein-Tyrosine Kinases
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metabolism
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Signal Transduction
7.Analysis of risk factors on Type 2 diabetic with foot ulcer.
Guo-Chang CHEN ; Quan-Min LI ; Mo YUAN ; Al ET ;
Chinese Journal of Practical Internal Medicine 2006;0(S2):-
Objective To analyze the risk factors on type 2 diabetic with foot ulcer.Methods 69diabetic foot patients were involved in the study.According to ulcer,patients were divided into the ulcer group(n=25)and the no-ulcer group (n=44).FBG,2h PBG,HbA1c,TC,TG,HDL,LDL,BUN,Cr.CRP were examined.T-test and chi-square test were used to assess the risk factors on diabetic foot patients with clure.Results Compared with the no-ulce group,the ulcer grou were associated with HDL and CRP.Chi-square-test demonstrated a statistically significant difference between the groups with ulcer and no-ulcer grou on incidence of hypertension and ulcer in diabetic foot patients(P
8.Comparison of TNM and Lugano staging systems in predicting 5-year survival rate of primary gastrointestinal lymphoma patients
Shujian CHANG ; Xin SHI ; Zhenyu XU ; Quan LIU
Chinese Journal of Clinical Oncology 2015;(7):392-396
Objective:To assess the survival-predictive value of TNM and Lugano staging systems in patients with primary gastro-intestinal lymphoma (PGL). Methods:A total of 73 patients with PGL were recruited from February 2001 to August 2013. All patients were diagnosed according to the TNM and Lugano staging systems. Five-year survival rate was used as the major clinical outcome. Sur-vival curves were plotted using the Kaplan–Meier method and analyzed with the log-rank test. The prognostic value of different vari-ables for clinical outcomes was assessed using the Cox multiple regression model. Results:The median follow-up time of surviving pa-tients was 42.4 months (range:1.3-158.6 months). The estimated 5-year overall survival rate was 77.82%. When diagnosed with the TNM system, the 5-year survival rates in stagesⅠ,Ⅱ,Ⅲ, andⅣwere 100%, 90.0%, 67.4%, and 22.2%, respectively (χ2=17.7956, P=0.0005). When staged by the Lugano system, the 5-year survival rates in stagesⅠ,Ⅱ,ⅡE , andⅣwere 100%, 100%, 70.7%, and 46.2%, respectively (χ2=15.6776, P=0.0013). Cox analysis showed that the invasion depth (T) (P=0.0181) and metastasis (M) (P=0.0031) were covariates that were prognostically significant for the overall survival. Conclusion:The TNM staging system is more ac-curate than the Lugano system in predicting the 5-year survival rate of patients with PGL.
9.A 6-week mindfulness-based training on aggression and sleep quality in long-term incarcerated males
Quan YUAN ; Kun JIA ; Xinghua LIU ; Weidan LIU ; Chang YANG
Chinese Mental Health Journal 2015;(3):167-171
Objective:To investigate whether the mindfulness training can reduce the aggression level and im-prove the sleeping quality among incarcerated people.Methods:Fifty-four male criminals were recruited into the study.They were divided into mindfulness training group (n =25)and control group (n =29).The training group took mindfulness exercise once a week for 6 weeks.While the participants in waiting list control group waited for 6 weeks without intervention.After 6-week mindfulness training for training group and post-assessment for all partici-pants,the waiting list control group went into 6-week mindfulness training.The Five Facet Mindfulness Question-naire (FFMQ),Aggression Questionnaire (AQ)and Pittsburgh Sleep Quality Index (PSQI)were assessed before and after the intervention.Results:There were 19 valid data in training group,and 21 in control group.After 6-week training,the score difference between pre-and post-assessment of FFMQ (P <0.01 )was higher in the training group than in the control group,and the difference of AQ (P <0.01)and PSQI (P <0.01)was lower in training group than in the control group.Conclusion:The results suggest that 6-week mindfulness training could effectively reduce the aggression level and improve the sleep quality in the long-term incarcerated males.
10.Research progress in anti-tumor effect of emodin.
Wan-fu LIN ; Chen WANG ; Chang-quan LING
China Journal of Chinese Materia Medica 2015;40(20):3937-3940
Emodin is one of the main active ingredient of Rheum palmatum, and has anti-inflammatory, anti-bacterial, anti-viral and other effects. In recent years, it arouse concern since it has a significant anti-tumor effect with low toxicity. In this paper we mainly report the anti-cancer effects of emodin according to the studies of the past five years, including four parts such as inhibit tumor growth, inhibit migration and invasion, enhance the efficacy of combination therapy, increase chemosensitivity and attenuated side effects. We hope that our work may provide a reference for further study.
Animals
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Antineoplastic Agents, Phytogenic
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chemistry
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pharmacology
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Emodin
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chemistry
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pharmacology
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Humans
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Neoplasms
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drug therapy