ObjectiveTo observe the effect of comprehensive rehabilitation on elder hypertension.Methods136 old patients with hypertension were divided randomly into the simple recuperating group (control group) and comprehensive rehabilitation group (observing group) with 68 cases in each group. Patients in simple recuperating group were treated with routine medicine and meal therapy. Cases in comprehensive rehabilitation group were added with health education, recuperating with natural factors, kinesiatrics, psychology and view treatment, etc. The blood pressure, symptoms and dosage of medicine of patients of two groups were compared.ResultsAfter two months treatment, blood pressures of all patients of two groups were dwon and symptoms improved, but that of comprehensive rehabilitation group were more obvious (P<0.01 and P<0.05). While the number of persons ceasing or reducing dosage of medicine in comprehensive rehabilitation group was greater than that of in simple recuperating group (P<0.01).ConclusionThe comprehensive rehabilitation is effect on elder hypertension.

2 patients with tick fever had had an encephalo-meningitis complication, a rare condition with clinical symptoms similar with other type of encephalo-meningitis. In the diagnosis of encephalo-meningitis fever caused by Ricketsia, it must pay attention to the signs of conjunctive congestion, erythrema, especially the ulcerous lesions with high diagnostic value. The change in cerebro spinal fluid is not usually specific as meningitis caused by pyogenes bacteria. These are an increase of protein level, light decrease of glucose level and a minime increased of cell count. The early detection and specific treatment reduce the severity of the condition and cerebral symptoms can be reduced slower than the fever
Meningoencephalitis ; Encephalitis ; complications

51 patients with acute hepatitis B were studied at Infectious and Tropical Diseases Department, Hue Central Hospital with criteria of clinical features, transaminase 5 times higher than normal upper limit and positive HbsAg at hospitalized time. 62% of them admitted hospital from 1 to 14 days after developed disease, reminder admitted hospital later than 15thday. Symptoms: 45,1% patients no fever; 88,2% oligouria and dark urine; 58,8% without swell of liver; 9,8% bleeding; 9,8% faint. Test results: there were 11% of patients with prothrombin <60%, 82,4% with bilirubin <340µg/l. 62,7% with De Ritis<1, 35,3% with HbeAg(+) and 33,3% with HbsAg (+) remained for 6 months. HbsAg positive remained for 6 months is associated with the group of patients admitted hospital later than 15thday (X2=5.1, P<0,05), the group with no fever (X2=10.1, P<0,05), the group with oligouria and dark urine (X2=13.6, P<0,05) and the group with jaundice (X2=5.1, P<0,05). The associations also existed between bilirubin level <340µg/l and the remained HbsAg (+) for 6 months and HbsAg (+) at the patients’ admission and the remained HbsAg (+) for 6 months (X2=5.5, P<0,05 and X2=31.3, P<0,05, respectively). The latter is strongly positive association.
Hepatitis B ; Hepatitis B Surface Antigens

99 patients over 15 year old were treated at Hue central Hospital from July 2002 to May 2003. 45.5% was in male and 54.5% in female. The most prevalence of age group was from 15 to 24 years old (72.7%). The symptom of abdominal pain in Dengue haemorrhagic fever was 61.8% and 46.2% in Dengue fever, alvine flux in Dengue haemorrhagic fever was 58.8% and 47.7% in Dengue fever. Liver intumescence in Dengue haemorrhagic fever was 29.4% and 7.7% in Dengue fever, pain in epigastric region in Dengue haemorrhagic fever was 32.4% and 9.2% in Dengue fever. The signs of headache, retroorbital pain, muscles and joints, supracondylar intumescence and along to sternocleidomastoid muscle had equal prevalence in Dengue haemorrhagic fever and Dengue fever. Based on Dengue haemorrhagic fever degree of WHO, most of cases were in degree II (82.4%), degree I (11.8%) and degree III (5.8%). All 99 cases, who were diagnosed with Dengue haemorrhagic fever (100%) by basic systems, only 34.3% of cases with Dengue haemorrhagic fever were re-diagnosed by hospitals, the rest 65.7% cases were Dengue fever
Diagnosis ; adult ; dengue ; viruses ; epidemiology

At Hue Central Hospital, Transmitted disease department, 41 viral hepatitis with anorexia, flatulence and dyspepsia were divided into 2 groups: the control group using fortex, polyvitamin and the intervened group using pantyrase in addition. The study showed that acute hepatitis occurred more in male than in female patients, the most age at 16-45 years old (61%). The group using pantyrase got improvement on the symptoms of flatulence, dyspepsia, promoted the digestion and the appetition. The anorexia interrupted after 7.18  1.91 days in pantyrase group and 16.84  4.91 days in the control group
Anorexia ; Flatulence ; Hepatitis, Viral, Human

Objective To analyze the etiology of clinical cases of live attenuated varicella vaccine.Methods 64 samples of varicella vesicle fluid from 49 patients clinically diagnosed as varicella cases in phase Ⅲ clinical trial of live attenuated varicella vaccine in enterprises(the test site was Henan Province) were collected,extracted for DNA,and distinguished for wild-type strains and vaccine strains by PCR and restriction fragment length polymorphism(PCR-RFLP).Genotype was analyzed using the genotyping method recommended at the international(varicella-zoster virus,VZV) nomenclature meeting2008.Results 64 vesicle fluids were all wild-type strains(Pst Ⅰ~+Sma Ⅰ~-BssH Ⅱ~-Nae Ⅰ~-),and no vaccine-related cases occurred.All 49 isolates belonged to Clade 2.Additionally,compared with Clade 2,a synonymous mutation(T→C) in SNP18 082 was detected in all 49 isolates,and a mutation(C→A) in SNP790 was detected in one isolate.Conclusion In the clinical trial of live attenuated varicella vaccine in Henan Province,all the clinical cases were caused by infection of wild-type strain which belonged to Clade 2 genetic branch.

The rapid spread of Coronavirus Disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection has had a devastating impact on public health and the global economy. Tremendous efforts had been put on urgent development of prophylactic or therapeutic drugs against SARS-CoV-2,mainly smallmolecule antiviral drugs and monoclonal antibodies,to reduce the impact and burden of COVID-19. Currently,National Medical Products Administration(NMPA)of China or Food and Drug Administration(FDA)of the United States have approved three small-molecule drugs and three monoclonal antibodies for use. This paper reviews the clinical research progress and challenges of the main drugs against SARS-CoV-2 on the market at present.

BACKGROUND:Orthopedic lumbar disc herniation is a common and frequently-occurring disease which causes low back pain. Selection of surgical therapy and postoperation efficacy on lumbar disc herniation are hot focus in present study.
OBJECTIVE:To summarize current research and progress on surgical treatment of lumbar disc herniation. METHODS:The databases of PubMed and China National Knowledge Infrastructure were searched from January 1990 to January 2014 for articles on surgical treatment of lumbar disc herniation. Keywords were“Lumbar Herniated Disc;Surgical Therapy”in Chinese and English. Final y, 61 literatures were chosen.
RESULTS and CONCLUSION:There are a variety of surgical treatments for lumbar disc herniation at present, including traditional surgical procedures, lumbar fusion, percutaneous lumbar discectomy, percutaneous laser decompression, chemonucleolysis, artificial nucleus replacement, and artificial lumbar disc replacement. This study reviewed surgical methods, indication, efficacy and prognosis, and summarized the new progression of repair and therapy of lumbar disc herniation. Results found that posterior lumbar discectomy remains the most widely used and the most mature procedure, but this method has many complications and induces great trauma. Minimal y invasive treatment for lumbar disc herniation is considered to be the future direction for smal surgical trauma, less complications and fast recovery, but the surgical indications are narrow and the operation is relatively difficult, so this method stil needs more improvement and development. Lumbar disc replacement is a new treatment for lumbar disc herniation which has a good short-term postoperative fol ow-up, but the long-term prognosis stil has many problems and complications. Lumbar disc replacement needs more research and development in alternative materials and surgical approach, and should be widely applied after large-sample tests.

Objective The aim of this study is to review the surgical experience of bronchoplasty and pulmo-nary arterioplasty in treatment of central-type lung cancer. Methods From 2003 to 2005,36 cases of patients with central-type lung cancer underwent bronchoplasty and pulmonary arterioplasty. There were 28 males and 8 females with a mean age of 62 years. Accordlng to pTNM classification. 5 cases were in stage ⅡI B,and 27 in stage Ⅲ A and 4 in stage Ⅲ B. Histologically,there were 24 cases of squamous cell carcinoma,6 cases of adenocarcinoma,1 case of small cell lung cancer and 5 cases of adenesquamous carcinoma. Results No patients died in the perioperative peri-od. The overall 1-,3-, and 5-year survival rate were 74% (26/35) ,48% (11/23) and 33% (3/9) ,respectively.Conclusion The results suggest that bronchoplasty and pulmonary arterioplasty can decrease the proportions of total pneumonectomy and exploratory thoracetomy and expand the indication of operation. Bronchoplasty and pulmonary ar-terioplasty can be achieved with satisfactory outcome for central-type lung cancer,especially for those patients with ad-vanced lesions or poor pulmonary function.

OBJECTIVE:To systematically review the short-term efficacy and safety of paclitaxel combined with cisplatin in the treatment of advanced cervix cancer,and to provide evidence-based reference for clinical treatment. METHODS:Retrieved from CJFD,Wanfang database,VIP datebase,Cochrane library and EMBase,the randomized controlled trials(RCT)of paclitaxel+cisplatin(test group)versus surgery alone and/or combined with cisplatin(control group)in the treatment of advanced cervix can-cer were collected,and Meta-analysis was performed by using Rev Man 5.0 statistics software after extracting data and evaluating quality. RESULTS:A total of 9 RCTs were enrolled,involving 1 097 patients. Results of Meta-analysis showed total effective rate [OR=4.12,95%CI(2.91,5.83),P<0.001] in test group was significantly higher than control group,incidence of gastrointestinal re-actions [OR=0.22,95%CI(0.10,0.47),P<0.001] and incidence of alopecia [OR=0.48,95%CI(0.24,0.95),P=0.03] were signifi-cantly lower than control group;there were no significant differences in the incidence of myelosuppression [RR=1.02,95%CI (0.37,2.79),P=0.97] and incidence of allergic reaction[OR=1.87,95%CI(0.18,19.18),P=0.60] between 2 groups. CONCLU-SIONS:Paclitaxel combined with cisplatin has good short-term efficacy in the treatment of advanced cervix cancer,can reduce the incidence of adverse reactions and complications,with good safety. Due to the limit of research methodological quality,high quali-ty and large-scale RCTs are required for further validation of the conclusions.