Objective To investigate the possible mechanisms of ox-LDL on vascular smooth muscle cells (VSMC) with and without exogenous zinc finger protein A20 gene. Methods VSMC were trans-fected with plamid containing A20 gene and incubated with ox-LDL. TLR4 and LOX-1 mRNA expression were measured by RT-PCR. Results After VSMC incubated with ox-LDL, the expression of LOX-1 and TLR-4 mRNA reached a higher level. However, when VSMC were transfected with plasmid containing A20 gene, the NF-kB nuclear translocation and the ability of migration reduced to normal level. Conclusions ox-LDL can significantly activate NF-kB signaling system and enhance migration in VSMC. The activation may induce the inflammatory response in arterial wall, the migration of VSMC to the intima, and triggering the process of atherosclerosis. Transfecting plasmid containing A20 gene significantly inhibited the activation of NF-kB and the ability of migration of VSMC. A20 effects might be through inhibiting NF-kB signaling. Meanwhile, A20 blocked the development of atherosclerosis.

Hyperthyroidism with periodic paralysis is common in clinic,the curative effect of peroral drugs on it is not satisfactory. In order to evaluate the treatment of 131 I for periodic paralysis in patients with hyperthyroidism, fouty two patients with hyperthyroidism complicated with periodic paralysis were put on p.o. 5.0 9.0 mCi 131 I Na treatment and the remission rate of periodic paralysis was observed.The total effective rate was over 95%. It can be concluded that 131 I could be used as a routine therapy for periodic paralysis in most patients with hyperthyroidism for its safety and efficiency.

OBJECTIVE: As a new method of altitude training, stimulated living high-training low training (HiLo), can solve the problems in traditional altitude training. In this paper, we review the effect of simulated living high-training low on the related indexes of red blood cells and the expression of erythropoietin and hypoxia inducible factor-1mRNA to improve the development and application of HiLo, and make it better service for our athletes. DATA SOURCES: A computer-based online search of PubMed was undertaken for the articles published between January 1972 and December 2005, among which partial articles were retrieved according to relevant references with the keywords of "simulated living high-training low training (HiLo), indices of red blood cell, effect; erythropoietin, hypoxia inducible factor-1; gene". Meanwhile, we searched http://cnki.hunnu.edu.cn for the relevant articles published between 1996 and 2006 with the same key words in Chinese. STUDY SELECTION: The articles that involved the effect on the indices of red blood cell and the expression of erythropoietin and hypoxia inducible factor-1 mRNA in the model of stimulated living high-training low training through the first trial sport were chosen after the first selection. Then, the full texts of these articles were looked up to identify whether they were the relevant studies. Inclusive criteria: ①randomised controlled experiments; ②the experiment including control and intervention groups. Exclusive criteria: ①review articles; ②repetitive studies. DATA EXTRACTION: Totally 90 relevant articles were collected, of which 38 were accordant with the inclusive criteria and the 52 repetitive studies or review articles were excluded. DATA SYNTHESIS: ①Levine discovered that in HiLo the maximal O2 consumption (VO2max) in the training group was increased 5% in the mean and red cell 9% and the ability of exercise was largely improved, while the results of the control group had no significant changes. ②HiLo training can induce the production of hypoxia inducible factor-1, which regulates erythropoietin, and its production. The increase in erythropoietin triggers an increase in red cell mass and Hb concentration. This hematological acclimatization response facilitates the restoration of blood O2 content and improves tissue oxygenation. Continuous residence at moderate heights (over 2 000-2 500 m) could improve the oxygen transport capacity, augment VO2 max and enhance exercise performance by increasing the content of erythropoietin and hemoglobin concentration. ③HiLo can induce the expression of hypoxia inducible factor-1, but the problems that how it regulates the expression of erythropoietin and transport the signal, and HiLo can alert the portion of blood, which affects the ability of exercise still need further study. Then we will more clearly learn the mechanism of the effect of HiLo on the ability of athletes, and help to enhance their performance. CONCLUSION: HiLo can increase the expression of erythropoietin and hypoxia inducible factor-1mRNA and the generation of red blood cells, which leads to an increase in hemoglobincon concentration and hematocrit, and effectively improves the ability of athletes.

Ultrasonic scalpels,including incision type and aspiration type,are introduced from aspects of the principles,key technologies and clinical application.Uitrasonic scalpel has the advantages of less bleeding,exact incision,,safety,shortened time of operation and less damage to surrounding tissue.Some technology problems of ultrasonic scalpel are also summarized.It is pointed out that ultrasonic scalpel is the tendency and direction of clinical surgery development,which has extensive application prospects.

Humans ; Methyl Ethers ; toxicity ; Occupational Exposure

Objective To observe the CT features of mycoplasma pneumoniae pneumonia. Methods CT features of 40 adult patients with serologically proven mycoplasma pneumoniae pneumonia were retrospectively reviewed. Results The most common CT findings of mycoplasma pneumoniae pneumonia were ground-glass opacity (34/40, 85.00%) and consolidation (28/40, 70.00%). The other findings included nodules (18/40, 45.00%), thickening of the bronchovascular bundles (6/40, 15.00%), interlobular septal thickening (6/40, 15.00%), mediastinal lymphadenopathy (6/40, 15.00%) and pleural effusion (4/40, 10.00%). Most of the ground-glass opacity and consolidation showed tendency of lobular distribution and involving the lower lobes. In some patients, the absorption of the lesions was slower than the relief of symptoms. Conclusion CT findings of mycoplasma pneumoniae pneumonia have some features, and can provide help for the diagnosis of mycoplasma pneumoniae pneumonia.

Artificial intelligence (AI) is among the forefront science in recent years. The rapid development of intelligent medicine based on AI, a new concept in the medical field, has resulted in a large impact on traditional medicine. AI poses a great opportunity and also many challenges for clinical physicians. Recently, researches in the development and application of AI are increasingly published in the field of endocrinology, such as the diagnosis and prediction of diabetes and its complications, the optimizing treatment and blood glucose management, the development of artificial pancreas, the diagnosis and treatment of obesity, the prognosis of bariatric surgery, osteoporosis and fracture prediction, bone age analysis, non-invasive assessment of liver steatosis and fibrosis, diagnosis of acromegaly, pathological diagnosis of thyroid and pituitary tumors. Nevertheless, the clinical applications of AI for medicine are still at an initial stage. With the rapid development of AI, we are expecting that it will play a pivotal role in the field of endocrinology and metabolism in the future. This is a new era for medical community to embrace new technology. Only with the properly dealing with the innovation of AI, a win-win result could be achieved.

Objective:To investigate the changes of hyoid position and pharyngeal airway before and after sagittal split ramus osteotomy (SSRO) of skeletal mandibular prognathism. Methods:Sixteen severe skeletal mandibular prognathism cases(Class Ⅲ, 5 males and 11 females) were chosen. Pre and post operation lateral cephalograms analysis reflecting pharyngeal airway and position of the hyoid bone was performed. Results: ① After SSRO, the width of airway decreased significantly. ② The distance between the mandible and the hyoid bone was also decreased significantly. No significant differences were found regarding measurements of the hyoid bone to the cranial base in male patients. Conclusion: The distance from the mandible to the hyoid bone and the width of airway were decreased significantly after SSRO. It suggests that the tongue and airway might be reformed functionally to new environments following SSRO surgical treatment.

Objective To investigate the effects of early partial body weight supported stand training on depression and balance function after massive cerebral infarction.Methods 40 patients with depression after massive cerebral infarction were divided into 2 groups,training group(n=20) and control group(n=20).All patients were treated with routine medication and rehabilitation.The patients of the training group also received partial body weight supported stand training in addition.They were assessed with the Hamilton depression scale(HAMD) and the Berg balance scale(BBS) before and after the treatment.Results After 8 weeks of treatment,the scores of HAMD and BBS of the training group had improved significantly more than those in the control group(P<0.05).Conclusion Early partial body weight supported stand training on the patients with depression after massive cerebral infarction may obviously improve balance function and reduce the degree of depression.

GC retention index of volatilc component of Cyperus rotundus was studied by capillary Gas Chromatography, and the standard Gas Chromatographic diagram and GC retention in dex spectrum, which provide a new identification method for traditional Chinese medicine was established. This method may be used to difierentiate the genuine C. rotundus from other false or confusion products. The average CV (% ) of RI from 37 sets of C. rotundus from three differcnt producing areas were 0~0.24 The method posscsses well accuracy, comparability and good reproducibility