Objective To investigate and analyze the related factors about the occurrence of thyroid diseases induced by interfer‐on in treating the chronic hepatitis B .Methods A retrospective analysis and following up of 213 interferon‐treated patients with chronic hepatitis B were performed .They were treated for 48 weeks and Logistic regression analysis was performed to evaluate the risk factors of thyroid dysfuncion .Patients were followed up for 48 weeks after drug withdrawal .Results In 213 patients received interferon therapy ,there were 38 cases suffered thyroid dysfunction ,nine of which were hypothyroidism including six cases of Hashimoto′s disease and 3 cases of non‐autoimmune thyroid dysfunction ,six of which were hyperthyroidism including 3 cases of Grave disease and 3 cases of destructive thyroiditis ,five of which were subclinical hyperthyroidism and 18 of which were subclinical hypothyroidism .Until 48 weeks of following‐up after treatment ,all patients with thyroid function was normal .Logistic regression a‐nalysis showed that the risk factors of female(OR=3 .696) ,hepatitis C virus infection over the same period (OR=3 .675) and pre‐stored anti‐thyroid peroxidase antibody(OR=2 .008) were correlated independently with the suffering of interferon induced thyroid diseases in the chronic hepatitis B patients .Conclusion For patients with chronic hepatitis B virus using interferon therapy ,espe‐cially the woman who pre‐stored anti‐thyroid peroxidase antibody in a large number and infected with hepatitis C virus ,the clinical therapy should monitor the related index of thyroid function regularly to prevent the happening of thyroid diseases .