Objective To compare the effects of different nursing process on intestinal decompression. Methods Eighty-six patients undergoing intestinal decompression were randomly divided into the experimental group and the control group with 43 cases in each group. They used different nursing process during intestinal decompression, the effects were compared by χ2 test. Results The operation room contamination rate, incision contamination rate and stimulus rate to the medical staff in the experimental group were lower than those of the control group. Conclusions Using sterilized plastic bags on the rebuilding of nursing process of intestinal decompression can improve surgery staff's satisfaction and nursing quality of operation room.