Objective To investigate the change of cognitive function in the elders with first acute ischemic brain stroke.Methods The cognitive function was determined using senile cognitive function(SECF) scale in 110 senile patients with first ischemic brain stroke and 60 healthy elders.According to different sites of cerebral infarction identified by CT imaging,their cognitive functions were compared,respectively.Results The cognitive function obviously decayed in the elders after the first acute ischemic stroke and had the relation with age and site of the infarction.Conclusion The elders with first ischemic stroke have obvious disorder of cognitive function and could directly influence the recoveries of the patients.So,the therapy should include both somatic and cognitive function treatment.