Objective To explore the morbidity, diagnosis, treatment and prognostic influencing factor of 25 cases of male breast cancer. Methods The clinical characteristics, diagnosis, treatment and prognosis of 25 patients with male breast cancer were retrospectively analyzed. Results The morbidity of patients with male cancer was rela-tively low(1.1%), but they have older year(an average of 56 years), and longer course (an average of 39 months). The major pathological type was infiltrative cancer. The modified or traditional radical mastectomy combined with ra-diotherapy and chemotherapy and endocrine therapy were often applied. Conclusion Male breast cancer had lower morbidity, longer course and poorer prognosis.