The article mainly introduced development status of care robots for the older in the domestic and overseas, stated functions of care robots for the aged, listed problems of care robots for the older and put forward solutions. In addition, the article illustrated future development.

Recently the combination of acupuncture with assisted reproductive technology (ART) to increase the outcomes of ART is being widely studied. In this article, the literatures concerning random controlled clinical trials since 2002 are reviewed and the designs of the trials, especially the timing of acupuncture, are evaluated. Over the past 5 years, the related clinical trials have primarily showed that acupuncture done immediately before and after embryo transfer might increase the assisted reproduction rates, but still requiring further high quality trials with large samples; in addition, different stimulation modes could produce different result, and so far there has not been a consensus as to the optimal time-point for the acupuncture intervention during the in vitro fertilization-embryo transfer (IVF-ET) course. Since the effects of acupuncture change with women's endocrine cycles, it is important and possible to make a breakthrough in ART outcomes if acupuncture is performed at a suitable time point during the cycle of IVF/ET combined with ART.

Objective To investigate the rivalry mechanism of ginkgo in rat brain edema after intracerebral hemorrhage.Methods Totally 80 healthy Wistar rats were divided into 4 groups randomly(20 rats in each group).Fifty microliters saline(group A and group B) or auto-hemoglobin(group C and group D) was infused into the right caudate nuclears using stereo tactic guidance.Groups A and C were lavaged 50 g/L carboxymethyl cellulose sodium solution of 3 mL,groups B and D were lavaged the same amount of ginkgo(200 mg/kg) solution dissolved by 50 g/L carboxymethyl cellulose sodium solution once a day for 3 weeks.All the rats were decapitated after raised for 3 weeks,and superoxide dismutase,malondialdehyde,and the number of hemeoxygenase-1(HO-1) positive cells in brains were assayed.Results The differences in SOD and MDA contents as well as HO-1 positive cell number between every two groups were significant(P

Objective To investigate characteristics and psychological mechanisms of creativity of college students by using divergent thinking tasks and creativity potential test.Methods Totally 150 college students were selected and assessed with three types of open-ended divergent thinking tasks (unusual uses task,instances task,consequences task) and the Williams Scale of the Creativity Assessment Packet (CAP) in this study.The divergent productions were scored by two independent raters on fluency,originality,flexibility dimension,and the CAP results were analyzed on risk-taking,curiosity,imagination and complexity.Results (1) The results showed that scores on fluency,flexibility,and originality correlated with each other on each of the three different divergent thinking tasks (P＜0.01).(2) Scores on fluency and flexibility among the three different divergent thinking tasks significantly correlated with each other (fluency:r=0.22,P＜0.01; r=0.47,P＜0.01 ; r=0.26,P＜0.01 ;flexibility:r=0.26,P＜0.01 ; r=0.28,P＜0.01 ; r=0.18,P＜0.05),while the correction coefficients of scores on originality among the three tasks were not significant.(3) Most scores of fluency or flexibility of different tasks were significandy correlated with risk-taking and imagination (P＜0.05),while originality was correlated with different creativity potentials on each task (originality of instances task and imagination:r=0.18,P＜0.05 ; originality of consequences task and risk-taking:r=0.26,P＜0.01 ; originality of unusual uses task and complexity:r=0.17,P＜0.05).Conclusion The results suggest that fluency and flexibility are the general characteristics of divergent thinking,which are associated with imagination and adventure,while originality is specific nature of divergent thinking,which is associated with various creative potentials according to the tasks.

Objective:To study the effect ofmetformin combined with insulin aspart on the serum cholesterol(TC),total Bilirubin (TBil),uric Acid(UA),urinary Micro Protein(mAlb) levels and Maternal and Infant Outcomes of gravida with Gestational Diabetes Mellitus.Methods:84 patients ofgestational diabetes mellitus who received therapy from June 2014 to June 2016 in our hospital were selected.According to random number table,those patients were divided into the observation group (n=42) and the control group (n=42),on the basis of routine treatment,The control group was treated with insulin aspart,while the observation group was combined with metformin hydrochloride.The blood glucose index and the levels of TC,TBil,UA,mAlb and maternal and infant outcomes were compared.Results:After treatment,the levels of fasting blood glucose (FBG),postprandial 2h blood glucose (2hPG),glycosylated hemoglobin (HbA1c),TC,TBil,UA and mAlb in the observation group were significantly lower than the control group,the levels of TBil was significantly higher than the control group (P＜0.05);the incidence ofgestational hypertension,hydramnios,premature birth,cesarean section,giant child and neonatal jaundice were significantly lower than the control group (P ＜0.05).Conclusion:Metformin combined with insulin aspart was well for gestational diabetes mellitus,which could effectively improve the blood glucose indicators and TC,TBil,UA,mAlb levels,maternal and infant outcomes.

Objective To study the expression of WWOX gene in non-small cell lung cancer and its significance. Methods WWOX protein expression was evaluated by immunohistochemistry in 81 NSCLC patients(50 squamous cell carcinomas,31 adenocarcinomas and 20 adjacent normal lung tissues),and correlation with histopathologic(histotype,grade,tumor-node-metastasis,stage) and clinical characteristics was studied. Results WWOX expression was absent/reduced in 72.8% of NSCLC,whereas it was normal in 80.0% of adjacent normal lung tissues.WWOX expression was strongly associated with tumor histology and histologic grade(P

Objective To investigate the training scale and social demand of nursing undergraduates in recent five years in Henan province,and supply reference for trend of talent supply and demand in future five years in Henan province.Methods A cross-sectional questionnaire survey were taken,6 nursing colleges,78 hospitals took part in the survey.Literature searching and trend extrapolation method were used to predict the demand of nursing talents in Henan province from 2011 to 2015.Results Tertiary hospitals demand more nurses with bachelor degree than secondary hospitals; the appropriate proportion of nurses with bachelor degree in all nurses was 30％～50％; besides,a predictive model equation was proposed.Conclusions The scale of undergraduate nursing should develop in appropriate ratio based on the predictive values; we should strengthen undergraduate nursing education for all-around development to adapt tertiary hospitals and community nursing trend,and the predictive model equation needs continuous emendation.

Objectives To investigate the clinical significance of the airway inflammation mediators,eosinophil cationic protein (ECP) and urinary leukotriene E4 (LTE4),in children with respiratory syncytial virus (RSV) bronchiolitis. Methods A total of 120 inpatients with RSV bronchiolitis were classified into atopic and non-atopic groups. And 30 healthy subjects were se-lected as normal controls. Urinary LTE4 was determined by ELISA and ECP concentration in nasopharyngeal secretions (NPS) was tested by UniCAP100 allergen detector. The differences among groups were compared. Results The urinary LTE4 level in atopic group (172.21 ± 67.29 pg/ml) was elevated significantly (P<0.01) than that of non-atopic group (78.21 ± 28.78 pg/ml) and control group (44.22±16.14pg/ml). Significance was also found between non-atopic and control groups (P<0.01). Statistical anal-ysis indicated that urinary LTE4 positively correlated to serum IgE and ECP in children with RSV bronchiolitis (r=0.57,0.49;P<0.01). Conclusions The level of urinary LTE4 and ECP in NPS can provide the reference for treatment and prognosis of children with RSV bronchiolitis.

Aims To study the effects of clenbuterol on anoxia/reoxygenation( A/R) injury in neonatal Wistar rat cardiomyocytes and to explore whether its mecha-nism is related to reperfusion injury salvage kinase ( RISK) or not. Methods The cultured primary neo-natal cardiomyocytes were randomly divided into eight groups: ①normal culture group; ②anoxia/reoxygen-ation( A/R) group;③ clenbuterol ( 1 μmol · L-1 ) +A/R;④ICI118,551(10 μmol·L-1) + clenbuterol ( 1 μmol · L-1 ) + A/R; ⑤Metoprolol ( 10μmol · L-1 ) + clenbuterol(1μmol·L-1 ) + A/R group;⑥Metoprolol ( 10 μmol · L-1 ) + A/R group; ⑦PD98059 ( 20 μmol · L-1 ) + clenbuterol ( 1 μmol · L-1 ) + A/R group;⑧ LY294002(10 μmol·L-1 ) +clenbuterol(1 μmol · L-1 ) + A/R group. Cell via-bility was determined by the conventional MTT reduc-tion assay. The content of LDH in cultured medium was measured with colorimetry. Cardiomyocyte apopto-sis was determined by Hoechst33342 . Intracellular re-active species( ROS) were monitored by the fluorescent DCFH-DA. Total ERK2 and phosphorylated ERK were detected by western blot. Results Compared with A/R group, clenbuterol significantly increased vaibility of cells, reduced LDH release, lowered the rate of apop-tosis and ROS production. When addedβ2 receptor an-tagonist ICI118 , 551 , PI3 K inhibitor LY294002 and ERK inhibitor PD98059 , the effects of clenbuterol a-bove were inhibited; but β1 receptor antagonist Meto-prolol protected the cardiomyocytes from A/R injury, as evidenced by decreased LDH release and increased cell viability. There were no synergistic effects in the combined use of clenbuterol and Metoprolol. Conclu-sion clenbuterol exerts cardioprotective effects against A/R injury by inhibiting oxidative stress and apopto-sis. The protection of clenbuterol is inhibited by ICI118 , 551 , LY294002 and PD98059 . clenbuterol protects cardiomyocytes against A/R injury via RISK pathway by activation of β2 receptor.

Objective To compare effect and psychological state between ICU and conventional treatment in elderly patients with ischemic heart failure.Methods A total of 64 consecutives diagnosed as ischemic heart failure in the Second Center Hospital of Baoding from June 2013 to June 2014 were divided randomly into experiment and control group, each of 32 cases, after getting approval of our hospital's ethics committee and informed consent right of patients ,family members.The patients in experiment group were advised into ICU, and the patients in control group were into common ward, then compared the differences of cardiac functions,clinical effect and scale anxiety score (SAS), scale depression score (SDS).Results The left ventricular end diastolic diameter (LVEDd), ejection fraction (EF) and NYHA class in the two groups after treatment were both better than before, and the experiment group were significantly better than the control group (LVEDd: (56.7±4.1) mm vs.(59.2 ± 4.6) mm;EF : 0.49 ± 0.05 vs.0.42 ± 0.04;NYHAI degree: 23 vs 22;NYHA Ⅱ-Ⅲ degree: 11 vs 17;t =3.105,3.416;x2 =0.714,3.513;P＜0.05).The in-hosptical days and fees in experiment group were significantly less than the control group(t =3.846,3.913;P＜0.05).The treatment types in the two groups were no statistical difference (P ＞ 0.05).The death rate in-hosptical and follow-up in experiment group were both significantly lower than the control group(9.4％ vs.21.9％;12.5％ vs.28.1％;x2 =3.102,3.715;P＜0.05).The SAS, SDS scores in the two groups after treatment were both higher than before, and the control group were significantly higher than the treatment group(t =3.326,3.845;P＜0.05).Conclusion The serious condition of elderly patients with ischemic heart failure are better to ICU, which could greatly improve clinical effect and anxiety depression.