Objective:To investigate the efficacy of treatment of primary hepatic carcinoma by three different interventional theraputic methods.Methods:121 cases with moderate and advanced stages of HCC were treated with PEI +LP-TAE,chemoembolization,LP,and SLPGSTAE respectively.All cases were divided into two groups according to the tumor’s size:group A(＞8 cm)and group B(≤8 cm).The efficacy and survial incidence of the three different methods were analyzed.Results:62 of the 76 cases(81%)in group A and 16 of the 45 cases(35.5%)in group B were decreased in size after the same theraputic method,two groups had statistically significant (P＜0.01).In group A,9 cases treated with chemoembolization and LP were invalid.16 of the 36 cases became smaller after SLPGSTAE.The 1,2 and 3 year surval incidence of patients in group B were 77.6%、42.1%、18.4% respectively as compared with group A were 68.8%、40.0%、11.1%.Conclusion:PEI can cause small tumors to form nerosis,SLPGSTAE cn play dual embolization role and had no servious damage to liver function.