Objective To investigate the effect of nasal intermittent positive pressure ventilation(NIPPV) on the prognosis of infants with recurrent apenea of premature(AOP) for 12 months of correcting gestational age,thus to provide reference for the treatment of AOP.Methods The premature infants with recurrent AOP of the neonatal intensive care unit were divided into observation group and control group according to the random number table method.The observation group was treated with NIPPV,the control group was treated with nasal continuous positive airway pressure (NCPAP).All living premature infants were followed up for early intervention,hearing,visual acuity,physical and mental development after hospital discharge.Neonatal behavioral neurological assessment (NBNA) was given to the premature infants at the corrected gestational age of 40 weeks and 42 weeks,CDCC was used to test of the corrected gestational age of 1 year old,and the mental retardation,cerebral palsy,hearing impairment,severe deafness,blindness were assessed and compared.Results 123 cases were selected,including 2 cases were abandoned in the treatment,7 cases died(4 cases died during hospitalization,3 cases died after hospital discharge),5 cases were lost following up after hospital discharge,12 cases were treated with poor compliance,the actual research subjects were 97 cases,51 cases in NIPPV group,46 cases in NCPAP group.In NIPPV group,the NBNA score more than 35 points of 40 weeks and 42 weeks were in 38 cases(74.5％),47 cases(92.2％) respectively,which in NCPAP group were respectively in 28 cases(60.9％),37 cases (80.4％).There were statistically significant differences between the two groups (t =14.786,4.149,all P ＜ 0.05).In NIPPV group,MDI score ＜ 80 points,PDI score ＜ 80 points,mental retardation,cerebral palsy were respectively in 7 cases (13.7 ％),6 cases (11.8％),3 cases (5.9％),1 case (2.0％),which in NCPAP group were respectively in 15 cases(32.6％),14 cases(30.4％),8 cases(17.4％),5 cases(10.9％),there were statistically significant differences between the two groups (x2 =10.040,9.765,5.944,6.663,all P ＜ 0.05).In NIPPV group,the hearing impairment,very severe deafness,blindness were respectively in 2 cases (3.9％),0 cases (0.0％),0 cases(0.0％),which in NCPAP group were respectively in 7 cases(15.2％),2 cases(4.3％),2 cases (4.3％),there were statistically significant differences between the two groups (x2 =7.037,4.082,4.082,all P ＜0.05).Conclusion NIPPV in the treatment of premature infants with recurrent AOP has a certain improvement in prognosis.

Adenoma, Oxyphilic ; diagnosis ; metabolism ; Carcinoma, Renal Cell ; diagnosis ; metabolism ; Humans ; Immunohistochemistry ; methods ; Keratins ; analysis ; Kidney Neoplasms ; diagnosis ; metabolism ; Proto-Oncogene Proteins c-kit ; analysis ; Sensitivity and Specificity ; WT1 Proteins ; analysis ; Wilms Tumor ; diagnosis ; metabolism

Carcinoma, Renal Cell ; classification ; diagnosis ; genetics ; pathology ; Chromosomes, Human ; Humans ; Immunohistochemistry ; methods ; Kidney Neoplasms ; classification ; diagnosis ; genetics ; pathology ; Translocation, Genetic

Basic Helix-Loop-Helix Leucine Zipper Transcription Factors ; genetics ; metabolism ; Carcinoma, Renal Cell ; genetics ; metabolism ; Cell Cycle Proteins ; genetics ; metabolism ; Humans ; Melanoma ; genetics ; metabolism ; Microphthalmia-Associated Transcription Factor ; genetics ; metabolism ; Neoplasm Proteins ; genetics ; metabolism ; Oncogene Proteins, Fusion ; genetics ; metabolism ; Perivascular Epithelioid Cell Neoplasms ; genetics ; metabolism ; Sarcoma, Clear Cell ; genetics ; metabolism ; Translocation, Genetic

Objective To explore whether glycyrrhizin has protective effect on acute liver injury in mice by NF‐κB signaling pathway .Methods Totally 200 Kunming mice which the body weight were about 29 -30 g were chose and divided into 4 groups randomly ,50 cases in each group .The first group was the control group;the second group was acute liver injury group induced by CCl4 ;the third group was injected with Stronger Neo‐Minophagen C(SNMC) injection on the basis of second groups;the fourth group was treated with NF‐κB inhibitor (proDTC) on the basis of the third group .After 1 ,3 ,5 d treatment ,the serum expressing levels of ALT ,AST ,total bilirubin ,albumin of mice and prothrombin time were detected ,the Child‐Pugh score was calculated ,and the pathological observation was performed .Results The results showed that ,compared to the first group ,after CCl4 treatment ,the expressing levels of AST ,ALT ,total bilirubin and albumin ,the PT and Child Pugh score all were significantly increased(P<0 .05) , which indicated that the acute liver injury model induced by CCl4 was successfully established .After the treatment of SNMT (CCl4 +SNMT) in mice ,although the level of each index did not return to normal level ,with the extension of treatment time ,the level of each index was also significantly reduced (P<0 .05) .At the same time ,this effect could be reversed by NF‐κB inhibitor proDTC .Conclusion SNMT plays a significantly protective role in acute liver injury via regulating NF‐κB signaling pathway .

Based on the investigation of the scale of recruiting students in Chinese medicine colleges,the author thinks that Chinese medicine colleges and universities should develop the specialities featuring Chinese medicaine and the related rising specialties to provide personnel support for the development of the modern industry of Chinese medicine.

The authors investigated the medical higher universities enrollment and specialty setting of international economic & trade situation and proposed to strengthen the study and bold attempt of the differentiation of international economic & trade situation as well as to appropriately add some new branches to this specialty.Meanwhile,medical institutions must emphasize their medical characteristics.

Humans ; International Agencies ; Lymph Nodes ; pathology ; Lymphatic Metastasis ; Male ; Neoplasm Invasiveness ; Neoplasm Staging ; methods ; Prostate-Specific Antigen ; metabolism ; Prostatic Neoplasms ; pathology ; Seminal Vesicles ; pathology ; Societies, Medical ; Tumor Burden ; United States ; Urinary Bladder ; pathology

Aim To investigate the changes of plasticity and distribution in the lungs of asthmatic guinea pigs.Methods Guinea pigs were divided into asthma group and control group.Immunohistochemistry was used in this study to observe the changes of ERK1/2 and Elk phosphoryiation in the lungs of guinea pigs.Results There were significant changes in distribution of EPK1/2 and Elk in the lungs of asthma group.The positive cells were detected on the walls of respiratory bronchioles and alveolar ducts,especially on the smooth muscle layer and basement membrane.In addition,the numbers of positive cell were clearly increased in asthma group(P< 0.01). Conclusion There is close relationship between the EPK1/2 and Elk phosphoryiation and attack of asthma.It may be a reason for persistence and progress of asthma.

Objective: To explore the safety and efficacy of intravenous thrombolysis therapy with tissue plasminogen activator ( tPA) in aged acute ischemic stroke patients. Methods:The patients treated with intravenous tPA were analyzed and divided into≥80-year group (n=16) and <80-year group (n=79), and 30 hospitalized patients with the age above 80 years without thrombolytic therapy were selected as the control group. The prognosis of the three groups was compared. Results:①The incidence of ICH in the two thrombolysis therapy groups was 13. 9% and 18. 7% in 24h, and that of SICH was 5. 1% and 6. 3% with no significant difference (P>0. 05). ② No significant difference was found in favorable prognosis between the two therapy groups 90 days after thrombolysis (P=0. 771), while very bad prognosis rate was higher in the≥80-year group than in the <80-year group (P<0. 05). ③The≥80 years group had an increased favorable outcome compared with the control group (P<0. 05), while the very bad prognosis rate in the two groups showed no significant difference (P>0. 05). Conclusion:It is safe and effective for old patients to receive IV-tPA throm-bolysis therapy.