“Mechanical memory” approach was commonly used in the knowledge learning of traditional Chinese medicine, which makes students often feel that the knowledge is too abstract, and this method is thus ineffective. “Qihuang the way” using Unity 3D game development platform inte-grates the elements of medical knowledge of the Chinese medical history, and combines TCM theoretical knowledge learning with serious games , which can help invoke students' enthusiasm and improve learning efficiency in an entertaining way.

Objective To investigate the clinical effect of different fixed way of tumor chemotherapy patients with PICC .Methods Totals of 90 patients during June 2009 to June 2012 were randomly divided into experimental group and control group , with 45 cases in each group .Experimental group used the puncture vascular direction fixing way ,while control group used the “S” shape traditional fixed method .The breakage of catheter, catheter-related complications, patients ’ satisfaction and comfort of two groups were observed . Results In experimental group , catheter fracture rate was significantly lower than that in control group , and the difference was statistically significant (4.4% vs 20.0%, χ2 =5.075, P=0.024).Local bleeding occurred cases in experimental group were significantly less than that in control group (1 vs 9,χ2 =7.200,P=0.007). While phlebitis , catheter related infection , catheter obstruction , the complications such as tube out between two groups, no statistically significant difference was found (P>0.05).Experimental group had lower patients ’ satisfaction and comfort scores than control group , and the difference was statistically significant [(1.02 ±0.27) vs (2.16 ±0.35),(1.32 ±0.61) vs (2.45 ±0.67), t =1.173,1.528,respectively; P <0.05]. Conclusions Using the puncture vascular direction fixing way can reduce the local bleeding of PICC application and maintenance process , at the same time can prevent the PICC catheter fracture and increase patients ’ satisfaction and comfort in clinic .It is worth promoting clinically .