AIM: To study the effects of nabumetone on immunological fuctions in mice METHODS: After nabumetone was given ig to mice, the weight of thymus and spleen, phagocytizing function of macrophages, PHA- induced lymphocyte transformation were observed respectively in mice RESULTS: The weight of thymus and spleen was decreased, the phagocytizing function of macrophages was reduced, PHA- induced lymphocyte transformation was markedly inhibited with nabumetone in mice CONCLUSION: The immunological function in mice was significantly inhibited with nonsteriod anti- inflammatory drug- nabumetone