Paclitaxel(PTX), an effective anti-tumor drugs, is water-insoluble. And Cremophor as a solubilizer in its commercial formulation, Taxol® , often causes side-effects which limit its antitumor effect. We designed and synthesized PEGylated carboxymethyl chitosan-rhein(CRmP)conjugate, and further prepared PTX-loaded CRmP polymeric micelles(PTX/CRmP). CRmP conjugate was characterized by fourier transform infrared spectrum(FT-IR)and nuclear magnetic resonance spectroscopy(1H NMR). The particle size and surface morphology of PTX/CRmP were characterized by dynamic laser particle size analyzer(DLS)and atomic force microscope(AFM), respectively. The cytotoxicity of CRmP conjugate and PTX/CRmP against MCF-7 cells were evaluated by MTT assay. The results showed that CRmP conjugates displayed very low cytotoxicity and that PTX/CRmP exhibited better in vitro anti-tumor activity than Taxol® at the same drug concentration after a long-term administration.

Objective To evaluate the reliability and validity of the Chinese version of multidimen-sional existential meaning scale (MEMS-C) in college students. Methods The MEMS was translated into Chinese. A total of 453 college students was tested by convenience sampling method via online survery. Eighteen college students were surveyed by MEMS-C before and after a two-week interval in order to analyze the retest reliability of the scale. Results The fitting indexes of the confirmatory factor analysis were χ2=450. 510,df=74,P<0. 01,χ2/df=6. 088,GFI=0. 859,CFI=0. 930,RMSEA=0. 106,RMR=0. 074,SRMR=0. 0494. The correlation validity coefficient of the scale was 0. 617 (P<0. 01). Internal consistency relia-bility coefficient of the total scale,comprehension,purpose,and mattering factors were 0. 935,0. 893,0. 936, 0. 733. The retest reliability was 0. 908 (P<0. 01). Conclusion The MEMS-C has good reliability and va-lidity. It is suitable to measure the sense of life of college students.

Objective: To explore the effect of family doctor team service in the medical association model on empowerment behavior and health status of elderly patients with diabetes in the community. Methods: A total of 158 patients with diabetes who were diagnosed with free physical examination and were diagnosed as diabetic patients in 4 communities under the jurisdiction of Fuzhong Community Health Service Center From March 2018 to May 2018, we conveniently divided into intervention group (79 cases) and the control group (79 cases), according to whether or not to sign a family doctor. The control group was older people who did not sign up for a family doctor, the control group was given routine intervention according to the community chronic disease follow-up mode, while the intervention group gave the contracted family doctor on the basis of routine intervention, and carried out individual assessment, group management, group intervention, one-on-one guidance, and the body mass index, abdominal circumference, fasting blood glucose, HbA₁c, self-management ability of the two groups were evaluated before intervention and 6 months after intervenation. Results: There was no significant difference between the two groups before intervention (P >0.05). After 6 months of intervention,abdominal circumference, fasting blood glucose and HbA₁c was (79.5±5.0) cm, (6.1±0.7) mmol/L, (6.3±0.6)% in the intervention group, (85.2±11.4) cm, (6.5±0.8) mmol/L, (6.8±0.7)% in the control group, and there was significant difference between the two groups (t=2.142, 3.345, 4.820, P<0.05 or 0.01); the self-empowerment ability and the self-management was (37.7±1.7), (44.3±6.8) in the intervention group, (30.1±2.5), (36.5±2.8) in the control group, and there was significant difference between the two groups (t=22.344, 9.427, P<0.01) . Conclusion The family doctor team service under the model of medical association can improve empowerment behavior of elderly diabetic patients in the community and improve their health status.