Objective To observe the pharmacological effect of Jiaweisinisan (JWSNS) on alcohol liver diseases. Methods Feeding Wistar rats with alcohol induced the alcohol liver diseases model. Then JWSNS was used on the alcohol liver diseases model to observe the histological variation of liver and detect the effect on the liver’s expression of SOD, GSH-PX, CAT and MDA. At the same time, Xiaochaihu granule group was used as control. Results On the alcohol liver diseases model group processed with JWSNS, obvious decrease of pathological injury with expression of MDA in liver was observed, while a markedly increased expression of SOD, GSH-PX and CAT was detected. Conclusions JWSNS can prevent liver cells from peroxided injury by alcohol.

Objective To observe the clinical effect of Jiawei Sinisan (JWSNS) on patients with alcohol liver diseases. Methods 80 patients of alcohol liver diseases were divided into two groups, JWSNS and Xiaochaihu (as control) were used respectively to observe the variation of lipoprotein and the expression of hepatic fibrosis markers. Results The symptoms and indicators of patients were improved by JWSNS. The high variation of lipoprotein and the expression of hepatic fibrosis markers were obviously detected on alcohol liver diseases patients who were treated with JWSNS (with an effectivity of 97.5%). However, patients treated with Xiaochaihu had less therapeutic effect. Conclusions JWSNS can obviously regulate the fat metabolism, resist hepatic fibrosis, and improve the symptom of patients suffering from alcohol liver diseases.

Objective To study new preoperative preparation for primary hyperthyroidism. Methods Before operation, Lugol solution was used(5～10 getts/time, 3 times/d) for 10 days. On the 7th day, dexamethasone 20?mg was added to 5%～10% glucose solution 500?ml was consecutively used for 3 days before the operation. Results FT 3 fell to normal value after dexamethasone 20?mg was used once, and FT 4 fell to normalvalue after dexamethasone used 3 days. There was no any complication, such as thyroid crisis occurring in this series. Conclusions Dexamelhasone applied before operation as the preoperative preoparation for primary hyperthyroidism is testified a safe and effective method.

Objective To determine whether prenatal ultrasonography (US) score is more effective than renal pelvic anterior posterior diameter (PAPD) for the prognostic evaluation of fetal hydronephrosis.Methods Fetuses with hydronephrosis (PAPD≥ 10 mm) were examined by prenatal US in the third trimester.PAPD,renal parenchyma thickness (RPT) and pelvicaliceal morphology (PM) were measured and graded from 0 to 3 score on the basis of severity of hydronephrosis,then the total US score of each kidney was obtained.According to the follow-up results after birth,all the cases were divided into two groups:physiological and pathological hydronephrosis.Via Z test,paired comparison was made to analyze area under the curve (AUC) of US score and each of the other three factors.Results Confirmed by postnatal US and other clinical examinations,of 198 kidneys (158 cases ) with hydronephrosis,139 (70.20％ ) were physiological hydronephrosis and 59 (29.80％ ) were pathological hydronephrosis.AUC of PAPD,RPT,PM,US score was 0.897 (minimum),0.957,0.944 and 0.982 (maximum) respectively,and there was significant difference between AUC of US score and each of the other three ( P ＜0.05).US score was the best approach for differential diagnosis of fetal hydronephrosis.Conclusions Prenatal US score is more effective and accurate than the single factor (PAPD,RPT,PM) to differentiate fetal physiological and pathological hydronephrosis.It was a new quantitative method to evaluate the prognosis of fetal hydronephrosis,and should be disseminated and applied clinically.