Humans ; Spirituality

On the basis of summarizing the general situation of current internal and external network construction of hospitals,the paper introduces the main hidden dangers of hospital network security,puts forward internal and external network security management measures,and elaborates the internal and external network security construction principle,network topology structure,and network construction achievements of the First Affiliated Hospital of Guangxi Medical University.

With rapid ageing population,the extensive application of mechanical ventilation and development of organ transplantation,infection caused by gram-negative (G-) bacilli,which have become the common pathogens causing nosocomial (especially ICU) infection,has increased and accounted for more than 65% of the hospital acquired infections.Severe infections in intensive care units are usually caused by Pseudomonas aeruginosa,Acinetobacter sp.,Enterobacteriaceae bacteria and Stenotrophomonas maltophilia,presenting challenges to the treatment.In addition,drug-resistant G-bacilli strains have increased year by year,accompanying with appearance of muti-drug resistant and pan-resistant strains of Pseudomonas aeruginosa and Acinetobacter baumannii.Several pathways may lead to drug resistance of G-bacilli,including permeability changes in ectal membrane,reformation of penicillin-binding protein,enhancement in level of pump MexAB-OprM,overproduction of antibiotic modification enzymes such as cephalosporinase,new type of beta-lactamases especially extended-spectrum beta-lactamases (ESBLs),AmpC beta-lactamase and Klebsiella pneumoniae carbapenemase (KPC).Clinical work is facing the challenges caused by drug resistance of G-bacilli,so the isolation and cultivation of pathogenic bacteria,drug sensitivity test in vitro,monitoring of drug resistance and researches on resistant mechanism should be enhanced,and proper antibiotics should be selected for treatment of G-bacilli infection.Polymyxin is recommended,if necessary,for treatment of multi-and pan-resistance G-bacilli infection,meanwhile the adverse effects of polymyxin treatment should be closely monitored.

Objective To evaluate CT features and diagnostic value of fungus infection of paranasal sinuses. Methods CT findings in 16 patients with fungus infection of paranasal sinuses proved surgically and pathologically were analyzed.Results CT findings of fungus infection of paranasal sinuses included: unilateral involved, maxillary sinus was mainly affected or other paranasal sinuses involved simaltaneously, the soft tissue within paranasal sinuses presented as hyperplasia of nodule and polyp-like, and there were some punctuated and tubercular calcification inside .Sinus cavity enlarged and the bone wall was destroyed in some cases. Conclusion CT manifestations of fungus infection of paranasal sinuses are of characteristics, CT scan is of important value in diagnosing this disease.

This article summarized literatures in the recent ten years on the mechanisms of Ci-xue therapy from such aspects as hemorheology, vascular biology, blood constituents and blood coagulating system.

Acupuncture Points ; Acupuncture Therapy ; Adult ; Aged ; Anti-Anxiety Agents ; therapeutic use ; Anxiety Disorders ; drug therapy ; etiology ; therapy ; Combined Modality Therapy ; Female ; Humans ; Male ; Middle Aged ; Stroke ; complications

Virtual Reality is just emerging as an accepted scientific discipline. It has been widely used in medicine. The major applications of virtual reality for medicine are introduced from three areas :virtual humans,the fusion of virtual humans with real humans and virtual telemedicine. The advanced graphics behind medical virtual reality,such as computational demands,hardware and software environments is briefly discussed. This article also gives a summary of existing distributed VR systems.

Objective:To research expression and function of c-myc gene in hyperacute r ejection of xenotransplantation. 　　Method:Through the model of hyperacute rejection of xenotransplantation wit h isolated rat heart perfused with human plasma,we detected c-myc mRNA expressi on and cell localization with in situ hybridization in hyperacute rejection. 　　Result:c-myc mRNA increased expression in the endothelium cell of heart.Th e value of signal is 450.09±409.99.The value of signal of group of control is 1 74.40±51.50(p＜0.05)。 　　Conclusion:From these study findings,it would appear that hyperacute rejecti on is associated with the elevation of c-myc mRNA expression.

MiR-200 family is a cluster of miRNAs closely linked to EMT. The miR-200 family contains miR-200a, miR-200b, miR-200c, miR-141 and miR-429. Many studies have shown that miR-200 family are key regulators of EMT and determine the epithelial phenotype. They are important to both EMT development and tumor progression. This paper reviews the advancement in the research of miR-200 family and its mechanism.

OBJECTIVE:To study the consistency policies of generic drugs in China,America and Japan comparatively,and provide reference for perfecting quality and efficacy consistency evaluation of generic drugs in China. METHODS:Generic drugConsistency evaluationQuality evaluationDESIwere used as keywords to search the related literatures or information of ge-neric drugs published or reported in CNKI,Web of Science,Elsevier,Springer database and USA FDA website during Jan. 1st, 1950-Jun. 30th,2016. And comparative analysis was conducted for the historical background,evaluation methods and policy influ-ences of consistency policies of generic drugs in China,America and Japan. RESULTS:There were differences in the historical background,evaluation methods,major participants and policy influences of consistency policies of generic drugs in China,Ameri-ca and Japan. The evaluation for generic drugs in USA was reevaluation of the drugs effectiveness under the history of drug registra-tion regulation was imperfect. With experts'review,it was evaluated based on FDA,enterprises,scientific literature evidence and experts review. Main evaluation method was in vitro dissolution test in Japan. The consistency evaluation of generic drug in China focused on the generic drug marketing authorization,mainly using in vivo bioequivalence. And the standards of reference prepara-tions were from the basically similar drugs to the original drugs. CONCLUSIONS:Compared with innovation-based countries like America and Japan,the availability of reference preparations in China is low,and policy environment is more complex. China should further improve the laws and regulations,giving reasonable buffer period,considering the diversity of evaluation methods, exemptions in special circumstances and current situation of pharmaceutical industry,paying attention to the balance between techni-cal supervision and system supervision.