Object To study the action of lotus leaf extract (LLE) in scavengings hydroxyl and superoxide anion radical Methods By spin trapping with electron spin resonance Results 26 94 ug/mL LLE can scavenge 65 60% superoxide anion radical (O ? 2) produced by Hypoxanthine Xanthine oxidase system, while at concentrations over 8 98 mg/mL a complete eradication of hydroxyl radical (?OH) produced from Fenten reaction system was achieved Conclusion LLE is highly effective in scavenging ?OH and O ? 2 free radicals