Objective:To investigate the predictive value of QT interval dispersion (QTd),cor rected QT interval dispersion (QTcd) and corrected QT interval(QTc) of car diac events in patients with congestive heart failure (CHF).Methods: QTd、QTcd、QTc and QTcd/QTc of 106 CHF patients were reviewed. Results:QTd、QTcd、QTc and QTcd/QTc of patients with and without cardiac events had significant difference respectively(P<0.05、<0.01、<0.05、<0.001 respectively).Conclusion: QTd、QTcd、QTc and QTcd/QTc are independent factors in predictin g cardiac events of CHF patients. In which,QTcd/QTc is the most accurate factor.

AIM: To observe the changes of transient receptor potential channel 5 (TRPC5) in vascular smooth muscle cells ( VSMCs) of apolipoprotein E-knockout ( ApoE-/-) mice and the effect of atorvastatin interference, and to investigate the mechanism of atorvastatin therapy.METHODS:Male ApoE-/-mice at 6 weeks of age were used to establish the atherosclerosis model by feeding with hyperlipidic diet.The mice were randomly divided into model group and atorvastatin group.The mice in atorvastatin group were lavaged with atorvastatin at 20 mg· kg-1 · d-1 , while the mice in model group received normal saline.The healthy C57BL/6J mice with the same age and the same genetic background, feeding with ordinary food, served as control group.At the time points of 14 and 24 weeks, the mice were sacrificed.The serum was collected for detecting the lipid levels.The aortic roots of the heart were taken to make paraffin sections with HE staining for measuring and comparing the relative atherosclerotic plaque area in each section.The expression of TRPC5 in VSMCs was examined with immunohistochemical staining.The mRNA levels of TRPC5 in the serum and the thoracoabdom-inal aorta were measured by real-time PCR.RESULTS: Compared with model group, blood lipids in atorvastatin group were significantly decreased, and the formation of plaque under aorta intima also decreased.The protein expression of TR-PC5 in atorvastatin group decreased significantly compared with model group.Compared with 20-week model group, TRPC5 in 30-week model group showed increasing tendency, but has no statistical significance.Compared with 20-week atorvasta-tin group, TRPC5 of 30-week atorvastatin group declined.CONCLUSION: Atorvastatin suppresses TRPC5 expression, thus attenuating atherosclerotic development in ApoE-/-mice.

Objective To investigate the clinical characteristics of acute pulmonary embolism in the elderly and its differences between the elderly and non-elderly patients,and explore the predictive effect of red blood cell distribution width(RDW)on chronic thromboembolic pulmonary hypertension (CTEPH)in patients with acute pulmonary embolism.Methods A total of 129 consecutive patients with acute pulmonary embolism admitted into Affiliated Hospital of Binzhou Medical College were selected from Jan.2009 to Dec.2013.Clinical data including the basic data,blood routine test,blood gas analysis,Doppler echocardiography during admission were retrospectively analyzed.All the patients were followed-up.Ancillary findings and changes of the disease were recorded in detail during the follow-up period.SPSS 19.0 was used to analyze the results.Results The incidences of CEPPH and venous thromboembolism(VTE)in APE patients were higher in the elderly than in non-elderly.The mean RDW and pulmonary arterial systolic pressure on admission in APE patients were higher in the elderly than in non-elderly [(14.22±2.11)％ vs.(13.48± 1.69)％,P=0.033,for mean RDW] and [(54.82± 21.77)mmHg vs.(42.20 ± 19.36) mmHg,P=0.010 for pulmonary arterial systolic pressure].The mean RDW was higher in CTEPH patients than in patients without CTEPH [(16.79 ± 3.08) ％ vs.(13.68± 1.68)％,P=0.016].Multivariate Logistic analyses showed that the increased RDW level was an independent risk factors for CTEPH in APE patients(OR=1.535,95％ CI:1.094-2.155,P=0.013).The area under receiver operating characteristics curve(AUC)of RDW level for predicting CTEPH in APE patients was 0.856(95％ CI:0.706-0.987,P＜0.001),the corresponding cut-off point was 14.85％,and the sensitivity and specificity were 88.9％ and 87.5％ respectively.Conclusions The increased RDW level could predict the risk of CTEPH to a certain extent in APE patients.

Objective To analyze the clinical effect of infrapopliteal arteries revascularization in patients with limb ischemic ulcer.Methods Clinical data of 152 patients (152 legs) suffering from CLI ischemic ulcer from June 2011 to June 2013 undergoing arterial revascularization using angiosome concept were retrospectively reviewed.Patients were grouped according to runoff,WB angiography,the number of outflow,angiosome model of revascularization and quality of pedal arch.Results Reintervention or ampatation (RAO) rate within 12 months was higher in runoff 0 group that in runoff ＞ 1 group (P ＜ 0.05)and runoff 1 (P ＜0.05).WB (+) group vs WB (-) group of RAO rate within 12 months,ulcer healing rate within 12 months showed no statistical difference.Limb salvage rate within 18 months was higher in WB (+) group than that in WB (-) group (P ＜0.05).Ulcer healing rate within 12 months and limb salvage · rate 18 months in group IRw was lower than group DR (P ＜ 0.05) and group IRc(P ＜ 0.05).RAO rate within 12 month rate was higher in IRw group than in DR group (P ＜ 0.05) and group IRe (P ＜ 0.05).Ulcer healing rate within 12 months and limb salvage rate within 18 months in group NPA was lower than group CPA (P ＜ 0.05) and group IPA (P ＜ 0.05).RAO rate within 12 month rate was higher in NPA group than in CPA group (P ＜ 0.05) and group IPA (P ＜ 0.05).Conclusion The rate of limb salvage was higher in WB (+).IRc revascularization has similar outcome with DR revascularization in ulcer healing rate and limb salvage rate.Clinical effect of CPA and IPA are better than NPA.