Objective To compare the efficacy and side effect of radiotherapy and radiotherapy combined with chemotherapy for esophageal carcinoma. Methods 90 patients with esophageal carcinoma were randomly divided into tow groups: control group 45 patients and combined therapy group 45 patients. Radiotherapy was performed on the control group, radiotherapy combined with chemotherapy which consisted of Carboplatin, 5-Fluorouracil and Hydroxycamptothecine were carried out the combined group. The two groups were under the same technical conditions and radiation dose. Three radiation fields were performed on both two groups at 200 cGy each time. The total radiation dose were 6 400 ~ 6 800 cGy. Results The local tumor control rate of combined group were higher than control group markedly. The acute gastrointestinal tract reaction and myetlosuppression were more serious than the control group. However, the late radiation reaction were not significance between the two groups. The main late reaction were radiation esophageal stricture and lung fibrosis. Conclusion Radiotherapy combined with chemotherapy is able to enhance the local control rate, 1 year and 3 years survival rate for esophageal carcinoma, but the acute side effect also increased and the late reaction were not increased.

Objective To investigate the influencing factors on re-examination compliance of patients with breast cancer Who were in the stage of recovery.Methods By clinic services and telephones,we investigated the reexamination compliance of 189 cases of breast cancer.Results 66.1% of the cases took periodic re-examinations and on the opposite,33.9% of the patients didn't do so.Statistical meaning could be found from the difference of ages,living sites and survival time limits(P＜0.05).Conclusions The main factors to influence the re-examination compliance of patients with breast cancer are age,living site and survival time limit.And it is possible to improve the re-examination compliance of patients by enhancing health education,raising medicsl levels and service qualities,and creating comfortable environment for patients.

Objective To analyze the efficacy and debase the toxicity of radiotherapy combined with composite Kushen injection in treatment of esophageal carcinoma patients. Methods A total of 126 cases of esophageal cancer were treated by radiotherapy were analysed. All patients were treated with the continuative hyperfractionated radiotherapy. The total dose was 66 ~ 74 Gy/5 ~ 7 wk, 2.2 ~ 2.4 Gy/d of esophageal carcinoma patients. Two groups were given respectively delivered with the same radioactive dosages and methods.But the synthetic group was treated by radiotherapy with composite Kushen injection. composite Kushen injection was given at the dosage of 20 ml with 500 ml of saline infusion for 20 consecutive days. Results X-ray grades of esophageal cancer after radiotherapy. The grade I of X-ray manifestation after radiotherapy for patients in synthetic group was superior to that patient in the radiotherapy alone group. (60.4 % vs 41 %; ?2 =4.57, P

OBJECTIVETo explore a new technique to prevent the dispersal of Oncomelania hupensis snail through leading flood for irrigation by floodgate in irrigation schemes.

METHODSHydromechanical and biological were applied and to combine laboratory experiment with the field observation to form a new multidisciplinary regarding snail biological hydraulics and technical line. Findings including characteristics of hydraulics and biomechanics and move regulation etc. Physics parameter of snails were used to design and construct as well as to exam the effect of facilities and rebuilt floodgate which could prevent the snail dispersal.

RESULTSThrough five years efforts, the major achievements were found as: 1) the method in testing the special gravity of snail and snail eggs was determined. 2) the special gravity of snail was (1.8 +/- 0.01) g/cm(3) and special gravity snail eggs was (2.29 +/- 0.01) g/cm(3); the classification method and classified criterion of snail size were made based on geometrical characteristics of snail shell. Six special values indicating dropping and start speed of snail in running water were obtained; Five practical formula of snail dropping and start in water were established; threshold value and movement characteristics in water were observed and tested and move mechanism of snail dispersal in water was also clarified. Based on the findings from fundamental research, the facilities of "precipitation pool for snail" and "leading water from middle level of water body" that could prevent snail dispersal were designed and rebuilt in the endemic area. Through examination to these facilities, the rate of precipitating and blocking of snails reached 100%.

CONCLUSIONThe achievement of the study provided reliable theoretical basis for the rebuilt of floodgate and to development of models that could prevent the dispersal of snail effectively.

Agriculture ; Animals ; Disease Vectors ; Schistosomiasis ; prevention & control ; transmission ; Snails ; growth & development ; Specific Gravity

Objective:To investigate the application value of fecal Syndecan-2 (SDC2) gene methylated SDC2 (m SDC2) detection in colorectal cancer (CRC) screening among urban residents in Guangzhou City. Methods:A cross-sectional study was conducted in Shitan Town, Zengcheng District, Guangzhou City from July to December 2022. A community-based screening program for CRC was conducted among residents aged 40-74 years old. m SDC2 detection was employed in the participants, and those with positive results should be recommended to receive colonoscopy examination. The positive rate of m SDC2 detection, colonoscopy compliance rate, detection rate of intestinal lesions and clinicopathological characteristics were observed. The relationship between cycle threshold (CT) value of m SDC2 and intestinal lesions was explored. Further, the cost-effectiveness of screening was evaluated. Results:A total of 8 189 fecal samples were collected from 8 877 participants with the recovery rate of 92.25%. 8 048 qualified samples were enrolled in this study, consisted of 3 182 males (39.54%) and 4 866 females (60.46%), with the average age of 56 years old (40-74 years). The positive rate of m SDC2 detection was 7.99% (643/8 048), and the compliance rate of colonoscopy was 73.10% (470/643). 20 cases (4.25%) of colorectal cancer, 109 cases (23.19%) of advanced adenoma, 145 cases (30.85%) of non-advanced adenoma, 79 cases (16.81%) of polyps were detected. The detection rate of intestinal lesions was 75.11% and indicated significant differences in gender and age. 20 CRCs included 15 of stage 0-I, 4 of stage Ⅱ-Ⅲ and 1 of unknown stage. The CT value of m SDC2 was negatively correlated with the proportion of advanced colorectal neoplasms ( χ2=16.063, P<0.001). The total cost of the screening was 4.339 5 million yuan, the screening benefit was 28.506 2 million yuan, and the benefit-cost ratio was 6.57. Conclusion:The CRC screening strategy of fecal m SDC2 detection combined with colonoscopy has high colonoscopy compliance and detection rate of intestinal lesions, which is conducive to the detection of early CRCs, and has good cost-effectiveness. This study suggests that this method may be applied to the general CRC screening in China and contribute to the prevention of CRC. The CT value of m SDC2 may have a certain suggestion on the malignant degree of intestinal tumors.

Objective:To investigate the application value of fecal Syndecan-2 (SDC2) gene methylated SDC2 (m SDC2) detection in colorectal cancer (CRC) screening among urban residents in Guangzhou City. Methods:A cross-sectional study was conducted in Shitan Town, Zengcheng District, Guangzhou City from July to December 2022. A community-based screening program for CRC was conducted among residents aged 40-74 years old. m SDC2 detection was employed in the participants, and those with positive results should be recommended to receive colonoscopy examination. The positive rate of m SDC2 detection, colonoscopy compliance rate, detection rate of intestinal lesions and clinicopathological characteristics were observed. The relationship between cycle threshold (CT) value of m SDC2 and intestinal lesions was explored. Further, the cost-effectiveness of screening was evaluated. Results:A total of 8 189 fecal samples were collected from 8 877 participants with the recovery rate of 92.25%. 8 048 qualified samples were enrolled in this study, consisted of 3 182 males (39.54%) and 4 866 females (60.46%), with the average age of 56 years old (40-74 years). The positive rate of m SDC2 detection was 7.99% (643/8 048), and the compliance rate of colonoscopy was 73.10% (470/643). 20 cases (4.25%) of colorectal cancer, 109 cases (23.19%) of advanced adenoma, 145 cases (30.85%) of non-advanced adenoma, 79 cases (16.81%) of polyps were detected. The detection rate of intestinal lesions was 75.11% and indicated significant differences in gender and age. 20 CRCs included 15 of stage 0-I, 4 of stage Ⅱ-Ⅲ and 1 of unknown stage. The CT value of m SDC2 was negatively correlated with the proportion of advanced colorectal neoplasms ( χ2=16.063, P<0.001). The total cost of the screening was 4.339 5 million yuan, the screening benefit was 28.506 2 million yuan, and the benefit-cost ratio was 6.57. Conclusion:The CRC screening strategy of fecal m SDC2 detection combined with colonoscopy has high colonoscopy compliance and detection rate of intestinal lesions, which is conducive to the detection of early CRCs, and has good cost-effectiveness. This study suggests that this method may be applied to the general CRC screening in China and contribute to the prevention of CRC. The CT value of m SDC2 may have a certain suggestion on the malignant degree of intestinal tumors.