The authors study the character of properties,micro-organization and general physical and chemical identification of Radix Tetrastigmae from Zhejiang and Guangxi,that provides an experimental basis for identification and establishing quality specifica- tions of Radix Tetrastigmae.

Objective To analyze the clinical features and risk factors for mortality of patients with severe fever with thrombocytopenia syndrome (SFTS) in Zhoushan, the eastern coastal of China with high incidence of severe fever with thrambocytopenia syndrome bunyavirus infection, to provide reference for reducing the mortality rate of SFTS.Methods Clinical data of 107 cases of SFTS from Zhoushan Hospital during June 2011 to June 2016 were retrospectively analyzed.According to the prognosis, patients were divided into survival group and death group.The clinical features and the laboratory results were analyzed with a case-control method to analyze the prognostic factors.Normal distribution data were compared with the independent t test.Kolmogorov-Smirnov Z test were used in data with skewness distribution.Categorical data were analyze by chi-square test.The related risk factors were analyzed with the receiver-operating characteristic (ROC) curve and multivariate unconditioned logistics regression analysis.Results Seventeen cases among 107 STFs patients died, yielding the mortality rate of 15.9%.The proportion of patients suffering from two or more underlying diseases, with disorders of consciousness, activated partial thromboplastin time (APTT), the level of creatine kinase (CK), lactate dehydrogenase (LDH) as well as sepsis-related or sequential organ failure assessment (SOFA) score in death group were all significantly higher than those in the survival group (all P<0.05).The Ca2+ level and fibrinogen level in death group were significantly lower than those in the survival group (both P<0.05).Indexes mentioned above were analyzed by ROC curve, and the calculated cut-off value was set as the optimal diagnostic thresholds.These data were then included into the multivariate logistic regression analysis.It turned out that Ca2+<1.625 mmol/L, APTT >73.45 s, SOFA scores >9 were the independent risk factors for mortality of SFTS (OR=6.947, 8.459 and 11.770, respectively, all P<0.05).Conclusion Ca2+, APTT and SOFA score are the independent risk factors for prognosis of SFTS, which provide reference for prognostic evaluation of SFTS.

Objective:To survey the status quo of community practice bases for general practice residency training in Sichuan province.Methods:The study was a cross-sectional survey. Online questionnaires were distributed via a WeChat group to 71 teaching managers of primary practice bases for general practice residency training in Sichuan Province in April 2023, and was completed anonymously. The questionnaire was designed according to the Standard for Residency Standardized Training Bases in General Practice (2022 Revision) (referred to as the Base Standard), the Content and Standard for Residency Standardized Training-Rules for General Practice Training (2022 Revision) (referred to as the Rules), and the relevant literature. The contents of the questionnaire included the basic information of the teaching managers and their institutions. Results:Seventy-one questionnaires were distributed. A total of 52 questionnaires were filled, and 51 valid ones were returned with an effective recovery rate of 71.8%. The participants were from 17 urban areas in Sichuan province, including 10(19.6%) base directors, 19(37.3%) teaching directors, and 22(43.1%) teaching secretaries. Among 51 participants, 49(96.1%) knew the rules; and 49(96.1%) had received teacher training. More than 70% of the bases had classrooms, meeting rooms or libraries, projectors, and reference books on general medicine; 50(98.0%) bases met the requirements for faculty number and quality set by the base standard; 49(96.1%) had teaching teams, 45(88.2%) bases had held upgrading causes for teaching faculty, 47(92.2%) set up incentive mechanisms for teaching faculty, and 39(76.5%) of the teaching managers thought that the teaching faculty in their institutions was qualified; and 26(51.0%) thought the leadership of the bases fulfilled the "main leadership responsibility system". All bases had set up resident management system; over 70% of the bases had completed the system for enrollment, assessment, lecturing, case discussion, and teaching clinics. The main problems in the teaching bases included unequal ability of teaching team, lack of guidance and cohesion, and imperfect organization structure, etc.; and the awareness and willingness of teaching faculty need to be enhanced, the quality and teaching ability of teaching faculty need to be improved, and more attention should be paid by institutions to the training bases.Conclusion:The vast majority of community practice bases for general practice residency training in Sichuan province comply with the Standards in terms of scale, basic conditions, faculty requirements, and teaching requirements, but there are still certain problems that need to be further improved.

Objective:To compare the clinical efficacy and safety of ledipasvir/sofosbuvir (LDV/SOF) and elbasvir/grazoprevir (EBR/GZR) in treatment of patients with chronic hepatitis C (CHC).Methods:The clinical data of 143 patients with genotype 1b CHC treated in Huzhou Central Hospital from January 2020 to December 2021 were retrospectively analyzed, including 74 cases treated with LDV/SOF and 69 cases treated with EBR/GZR. The virological response after 4 and 12 weeks of treatment and 12wk after drug withdrawal was determined; and the serological and liver inflammation indexes before and after treatment in two groups were compared. SPSS 25.0 software was used for statistical analysis of the data.Results:The virological response rates of the LDV/SOF group and EBR/GZR group were 97.30% and 98.55%, 98.65% and 100.00%, 97.30% and 98.55% after 4 and 12 weeks of treatment and 12 weeks after the end of treatment, respectively (all P > 0.05). At the end of treatment, the liver inflammation indexes ALT, AST and GGT in the two groups were significantly lower than the baseline levels ( Z=-7.470 and -6.974, -9.757 and -6.832, -3.578 and -4.054, P<0.01). Adverse reactions in both groups were mild, and no serious adverse events occurred. Conclusion:Both LDV/SOF and EBR/GZR have good clinical efficacy in the treatment of genotype 1b CHC patients. And the patients are well tolerated.