Objective] To summarize the academic thought and clinical experience of Professor Lian Jianwei in diagnosis and treatment of diseases of spleen and stomach. [Methods] Through clinical practice following tutor and analysis of clinical cases, using the method of literature, we study Lian Jianwei's academic point of view and experience of prescription and herb in diagnosis and treatment of diseases of spleen and stomach.[Results] Professor Lian pays attention to adjusting the ascending and descending of Qi, harmonizing liver and spleen, reconciling cold and hot syndrome, emphasizes eliminating dampness chiefly, coordinating attacking pathogen and strengthening the resistance of body, removing blood stasis in chronic illness, advocates to protect stomach Qi and the combination of disease and syndrome. In clinical practice, Professor Lian uses prescription and herb skillfully and gently, so achieves good curative effect in clinic. [Conclusion] Professor Lian has bright academic opinion in the treatment of diseases of spleen and stomach, analyses syndrome carefully, and has abundant clinical experience. His academic thought and clinical experience are worth studying and inheriting deeply for us.

Objective To analyze the hepatitis B virus infection with extreme reduction of cholinesterase(CHE)not caused by liver synthesis dysfunction,and to explore its clinical significance.Methods The clinical data of 2 rare cases hospitalized in the 3rd people's hospital of Kunming in July 2021 and February 2022,including liver function,coagulation function,hepatitis B markers,hepatitis B virus volume,and whole exon sequencing,were collected and analyzed,and literature was reviewed.Results CHE was extremely reduced in 2 patients with HBV infection,liver synthesis function was good,and whole exon sequencing showed the presence of butyrylcholinesterase(BCHE)gene mutation.Conclusion The extremely low CHE in this case is not due to liver function disorder.Exon sequencing detected mutations in the BCHE gene in two patients.Screening for BCHE mutations may be necessary in patients with extremely low cholinesterase levels not due to liver dysfunction.