1.Analyzing Main Problems and Measurements in Financial Acceptance of Scientific Research Tasks
Chinese Health Economics 2014;(3):86-89
There are many existing problems of scientific research task financial acceptance in policy reference, acceptance content, organization form and methods. Specific measurements and suggestions of improvement are proposed on the basis of detailed list and analysis.
2.Analysis on Financial Management of Scientific Research Project
Chinese Health Economics 2013;(12):93-97
Problems of budget enforcement, financial accounting, expenditure balance and equipment material calculation exist in financial management of scientific research project , and relevant policies and suggestions are provided on this basis.
3.Main Problems in Research Projects Budgeting Preparation and Countermeasures
Chinese Health Economics 2013;(7):83-85
In the current research project budgeting preparovtion, there are many problems in the arrangement of construction, literal statement, and table settings; and the description of subject expenditure’s relevant to the objectives, consistent with policies and economic rationality. Based on the detailed presentation of problems and serious analysis, strategies and suggestions on budget improvement are proposed.
4.Application of parvule-impacted bone graft in the posterior lumbar interbody fusion
Qingming ZHANG ; Huiliang SHEN ; Li CAO
Orthopedic Journal of China 2006;0(11):-
[Objective] To investigate the feasibility of posterior interbody parvule-impacted bone graft fusion.[Method] A retrospective study was performed in 31 patients admited to our hospital in 2003~2006(M=14,F=17).The ages were 55 to 80,with an average of 66.2 years.There were 9 cases of spondylolisthesis,6 of degenerative unstability and 16 of developmental stenosis.All patients underwent posterior interbody impact bone graft fusion and pedicle screw fixation.The pre-and post-operative JOA score were used to calculate the improvement rate.The postoperative bending-extending plain films were taken to observe whether the fusion was successful.[Result]All patients were followed up for 12~18 months.Three patient had leg symptoms at postoperation and were released 3 months later.Thirteen patients had fusion at 6 month,16 had union at 12 month,and 2 had union at 18 month.The lumbar lordosis angle and intervertebral height got significant restoration.The spinal fusion rate was 100%.No dura tear leakage of cerebrospinal fluid or wound infection was found.No graft absorption,displacement or collapse occurred.There were 16 cases excellent,12 cases good,and 3 cases fair.JOA score was 24~29(average 27.4?1.9)at postoperation.The improvement rate was 89.4%.[Conclusion] Posterior interbody parvule-impacted bone graft is a feasible fusion method.The method is simple and cheap,with advantages of less injury and high fusion rate.
5.Detection of telomerase activity and cytology in the diagnosis of cardiac cancer.
Qiang WANG ; Qingming WU ; Shengbao LI
Chinese Journal of Practical Internal Medicine 2001;0(07):-
Objective To investigate the diagnostic significance of cytology and telomerase activity in the exfoliated cells of cardia obtained from endoscopic brushing in the cardiac cancer.Methods The technique of the qualitative TRAP siver staining and quantitative TRAP PCR ELISA were employed to detect telomerase activity in the exfoliated cells of cardiac obtained from endoscopic brushing in 72 cases with cardial lesions,cytological diagnosis was made at the same time.Results Telomerase activity with cardiac cancer group(1\^521?0\^192)was significantly higher than that with cardialitis group(0\^065?0\^014).Positive rate of telomerase activity detected in cardiac cancer group(88\^89%)was significantly higher than that with cardialitis group(11\^11%).Positive rate of telomerase activity detected in cardiac cancer group(88\^89%)was significantly higer than cytological examination(77\^78%).The diagnostic rate of cardiac cancer was improved to 93\^33% if telomerase activity and cytology were examined at the same time.Conclusion Results show that the combination of cytology and telomerase activity in the exfoliated cardiac cells may be an effective and sensitive method in the diagnosis of cardiac cancer.This research can be a basis for the mass screening of cardiac cancer.
6.Clinical effect on the treatment of the low-middle frequency sudden hearing loss with postaurical injection of methylprednisolone.
Sien WU ; Qingming LI ; Suhong HUANG
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2015;29(10):928-930
OBJECTIVE:
To evaluate the clinical efficacy on the treatment of the low-middle frequency sudden hearing loss with postaurical injection of methylprednisolone.
METHOD:
The 80 cases of the low-middle frequency sudden hearing loss were randomly divided into postaurical injection and oral hormone groups. The postaurical injection group (42 cases) received the postaurical injection of methylprednisolone, 40 mg/2 d, combined with the treatment of Ginkgo dipyidamolum and Alprostadil for 14 d; The oral hormone group (38 cases) received the oral prednisone, 1 mg/kg/d, administrated once on the morning for 3 d, if effective, prolonging for another 2 d, as mentioned above for Ginkgo dipyidamolum and Alprostadil.
RESULT:
The total effective rate was 88.10% in postaurical injection group and 86. 4o%in oral hormone group. There was no significant difference between the twbogroups( P> 0. 5).
CONCLUSION
Postaurical injection of methylprednisolone for the low-middle frequency sudden hearing loss is effective, safe and simple, which may be an alternative for systemic administration of gulcocorticoid.
Alprostadil
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therapeutic use
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Biological Products
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therapeutic use
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Glucocorticoids
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administration & dosage
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therapeutic use
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Hearing Loss, Sensorineural
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Hearing Loss, Sudden
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drug therapy
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Humans
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Injections
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Methylprednisolone
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administration & dosage
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therapeutic use
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Prednisone
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administration & dosage
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therapeutic use
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Treatment Outcome
7.Significance of CD105 expression in laryngeal carcinoma
Qingming LI ; Baoquan ZHANG ; Peihong PENG
Basic & Clinical Medicine 2006;0(03):-
Objective To study the expression of CD105 in laryngeal carcinoma and to evaluate the clinical significance of microvessel density(MVD).Methods Pathologic paraffin-embedded sections and clinical data from 40 patients with primary squmamous cell carcinoma of larynx were studied through immunohistochemistry.Microvessel density(MVD) highlighted by CD105 and CD34 were counted.Results CD105 expression in tumour tissue was significantly higher than normal health mucosa.The mean CD105-MVD value of T3 and T4 tumours showed a significantly deeper staining than T1 and T2;The mean CD105-MVD value of tumours with metastasis was also markedly higher than tumours with no metastasis;The diffenerce of mean CD105-MVD value between in 16 patients with recurred laryngeal carcinoma and in 20 patients with unrecurred laryngeal carcinoma for two years of follow-up was markedly significant(P
8.Prospective Randomized Controlled Study on Two Anesthesia Methods for Ureteroscopic Pneumatic Lithotripsy
Qingming YE ; Huadan ZHANG ; Wenjie LI
Chinese Journal of Minimally Invasive Surgery 2001;0(04):-
Objective To compare the efficacy and side-effects of combined spinal-epidural anesthesia(CSEA)and epidural anesthesia(EA)for ureteroscopic pneumatic lithotripsy.Methods A total of 60 patients with ureteral calculi(ASA gradeⅠ-Ⅱ)were divided into A and B groups randomly(30 in each).CSEA was performed in group A,and EA was carried out in group B.Anesthetic effects and side-effects were observed in both the groups.Results Anesthetic effects were satisfying in both the groups,no patient had headache after the operation.The onset time of anesthesia in group A was shorter than that in group B [(7.2?4.1)min vs(17.4?3.3)min,t=-10.615,P=0.000].The level of motor block of CSEA was stronger than that of EA(?2=40.000,P=0.000).No significant differences were found between the two groups in the number of patients who developed hypotension(6 in group A and 3 in group B,?2=0.523,P=0.470)or shivering(9 in group A and 6 in group B,?2=0.800,P=0.371).Conclusions Both CSEA and EA are applicable to ureteroscopic pneumatic lithotripsy.CSEA is more efficient than EA.
9.Hemodynamic Assessment of Ischemic Stroke with Near-Infrared Spectroscopy
Weiguo CHEN ; Pengcheng LI ; Qingming LUO ; Shaoqun ZENG ; Bo HU
Space Medicine & Medical Engineering 2000;13(2):84-89
Objective To validate near-infrared cerebral topography (NCT) as a practical toolin tracing the regional hemodynamic changes during normal ischemic stroke model of rat. Method Middle cerebral artery occlusion (MCAO) and photosensitizer induced intracranial infarction model of rat were established. The geometric shape and infarction area were measured by NCT, functional magnetic resonance imaging (fMRI), and TTC stained anatomical imaging techniques. Result In photosensitizer induced infarction model, the correlation between anatomical infarct area and NCT image area for infarct focus were r= 0.897 for 24 h group (P<0.05) and r=0.906 for 2 months group (P<0.01),respectively. The correlation between anatomical infarction area and NCT image area for infarct focus were r=0.820 for normothermia group (P<0.05) and r= 0.851 for hypothermia group (P<0.05), respectively. The correlation between fMRI and NCT image area for infarction focus were r= 0.874 for normothermia group (P<0.05) and r= 0.782 for hypothermia group (P<0.05),respectively. Conclusion Measurement with NCT for infarction focus matched well with fMRI and anatomic sample in rats. NCT technique might be a practical tool for short-term prediction of stroke and the rehabilitation after stroke in real time.
10.Effects of Naohuandan Recipe on learning and memory abilities of SAM-P/8 mice and its role in anti-oxidation and anti-apoptosis
Qingming LI ; Rongsen MENG ; Changxiu WEI ; Fangju KAN ; Qihui HUANG
Journal of Integrative Medicine 2006;4(1):48-51
OBJECTIVE: To investigate the effects of Naohuandan Recipe on learning and memory abilities of SAM-P/8 mice and its role in anti-oxidation and anti-apoptosis. METHODS: Forty SAM-P/8 mice were randomly divided into four groups, which were untreated (normal saline-treated) group, Yinkeluo Tablets (extracts of gingko leaf)-treated group, low-dose Naohuandan Recipe-treated group and high-dose Naohuandan Recipe-treated group. Mice in these groups were given corresponding drugs orally for 105 days. Then the performances of learning and memory of mice were tested by a step-down passive avoidance task and a Y-maze test. The serum levels of superoxide dismutase (SOD), malondialdehyde (MDA) and glutathione peroxidase (GSH-Px) were detected. The expression level of bcl-xl mRNA in cerebral cortex and hippocampus of mice was detected by reverse transcription-polymerase chain reaction (RT-PCR). RESULTS: The performances of learning and memory in the Yinkeluo Tablets-treated group, low- and high-dose Naohuandan Recipe-treated groups were significantly improved as compared with those in the untreated group (P<0.05 or P<0.01), and such performance was the best in the high-dose Naohuandan Recipe-treated group among these four groups (P<0.01). The serum levels of SOD and GSH-Px and the expression of bcl-xl mRNA in cerebral cortex and hippocampus of mice in the Yinkeluo Tablets-treated group, low- and high-dose Naohuandan Recipe-treated groups were also significantly higher than those in the untreated group (P<0.05 or P<0.01), while the serum level of MDA in the untreated group was higher than that in the other three groups (P<0.01). CONCLUSION: Naohuandan Recipe can improve learning and memory abilities of SAM-P/8 mice, and this effect may be related to its anti-oxidation efficacy and enhancement of expression level of bcl-xl mRNA.