Objective To find earliest or the best time for children with neonatal dacryocystitis acceptable treatment of lacrimal to shorten the course and improve treatment Methods Different time points after birth accepted probing treatment efficacy in children with neonatal dacryocystitis were retrospectively analyzed. Results Probing technique was effective for newborn infant with dacryocystitis. Symptoms recovered in 47 eyes,and 26 eyes were significantly improved with only a simple washing,there are 33 eyes need to wash and rinse probe or the expansion of the sclera again,and it was more common in the disease course of 4 ～6 months. Once probing technique treatment in the group( within 3 days) were effective in 23/34(67. 7% ) ,more than it in the group(more than 4 days) with effect of 24/72(33. 3%), One probing technique treatment in the group(within 10 days) were effect of 12/53(22.6%). Conclusion Press and simple washing techniques ineffective in children with neonatal dacryocystitis, was depended on operator proficiency, and time of lacrimal passage sounding could really advance the treatment to patients within 10 days after birth.