Objective To evaluate the molluscicidal effect of niclosamide ethanolamine salt clustable powder (DP). Methods A comparative molluscicidal experiment was carried out by spraying method with niclosamide ethanolamine salt 4% DP. The experiments were respectively done in the labatory and field. The spraying with niclosamide ethanolamine salt 50% wettable power (WP) was used as the control. Results The molluscicidal effects of niclosamide ethanolamine salt 4% DP and 50% WP were similar in the laboratory. In the field, the effect of niclosamide ethanolamine salt 4% DP was lower than that of 50% WP in 3 d. However, the molluscicidal effects of the two formulations had not significant difference after 7 d. Conclusion The molluscicidal effects of niclosamide ethanolamine salt 4% DP and 50% WP were almost the same. DP is suitable for some areas where water are lack, or the water level are difficult to control.