Objective To synthetical analyse the current status of medication in portal hypertension (PHT) and the direction of development. Methods Papers of treatment of PHT in large quantity of cases and /or by standard clinical test were collected and reviewed. Results Treatment of PHT had been converted from surgery to medication gradually.The effect of medication had increased gradually with drug improvement.Conclusions Medication of portal hypertention is an effective and practicable technique to treat portal hypertention, and it is the research direction in the future.