[Objective]To analyze the characteristics of outpatient prescription drug withdrawal,reduce out-patient drug withdrawal to ensure the safety of patients with medication.[Method]Make statistics on outpatients from January to September of 2007,1292 prescription drug withdrawals,drug withdrawal rate accordingly,drug dosage forms,drug types,the cause of drug withdrawal classification.[Result]There're many pediatric drug withdrawal,injection drug withdrawal,retreat antibiotic drugs,drug withdrawal and the main reason is unreasonable adverse drug reaction.[Conclusion] Analyzing the characteristics of drug withdrawal to strengthen rational drug use can reduce the greatest degree of adverse drug reaction,reducing out-patient drug withdrawal to ensure the drug safe,effective,rational and economic.

OBJECTIVE: To determine the contents of total flavonoids and quercetin in different parts of Apocynum venetum collected in Songnen grassland and study their antioxidant activities so as to provide references for efficient utilization of the herbal plant.METHODS: Ultrasonic extraction was applied to extract total flavonoids.The content of total flavonoids was determined by chromatometry and the content of quercetin was determined by HPLC.The antioxidant activities of the extracts from different parts of A.venetum were evaluated by determining their abilities in scavenging 1,1-diphenyl-2-picrylhydrazyl(DPPH?) radicals and?OH radicals.RESULTS: The contents of quercetin and total flavonoids were richer in both leaves and flowers of A.venetum than in stems.In addition,the total flavonoids extracted from the leaves and flowers of A.venetum showed higher antioxidant activity than from the stems.CONCLUSION: The leaves,flowers and stems of A.venetum can all be used as raw materials of natural antioxidants.

The publication and citation of academic papers are important indexes to evaluate science research level of colleges and institutes and also important index to evaluate researchers. In this paper we calculated and analyzed the number of publications, cited number, and cited frequency of SCI papers in three military medical universities and one military medical research institution from 1997 to 2006, and put forward some opinions and suggestions.

Objective To investigate the molecular mechanism of CCl_(4) inducing fibrosis in hepatic stellate cells.Methods The expression of Transforming growth factor-?1(TGF-?1) at mRNA and protein level were detected by RT-PCR method and Western blot analysis.The proliferation and cell cycle distribution were detected with MTT method and flow cytometry.Results After treatment by(10 mmol/L) CCL_(4) for 24 hours,the mRNA and protein expression of TGF-?1 in CCl_(4) group sharply increased.In the meantime,the proliferation of CCl_(4) group cells was markedly increased.There were less G_(0)/G_(1) phase_() cells and more G_(2)/M phase cells in CCl_(4) group than those in control group.Conclusion Suitable CCl_(4) may increase the expression of TGF-?1 and the proliferation of hepatic stellate cells,which is one of mechanisms leading to hepatic fibrosis.

Objective To investigate the prevalence and the associated risk factors of fatty liver disease in railway employees.Methods 3 520 railway employees aged 21～60 were observed,1 299 cases of fatty liver who were diagnosed by uhrasonography and 2 221 normal controls.Plasma triglycerides(TG),total cholesterol(TC)and fasting blood glucose(FBG) were determined.Results The prevalence rate of fatty liver was 36.9%(1 299/3 520).It increased with age.The prevalence rate of fatty liver in the groups with different age was significantly different(x~2=14.82,P

OBJECTIVE:To establish HPLC method for the content determination of paeoniflorin in wind-dispelling and itching-arresting oral liquid.METHODS:The determination was performed on Hypersil Gold C 18 column,the mobile phase consisted of methanol-1.5%H 3 PO 4 (35∶65)with flow rate at0.6ml/min and detection wavelength at230nm under room temperature.RESULTS:Peoniflorin was linear with peak area score when its sample size was within the range of0.0404?g～0.2020?g(r=0.9997),the average recovery was98.1%(RSD=0.99%).CONCLUSION:The method can be used to control the quality of wind-dispelling and itching-arresting oral liquid.