The publication and citation of academic papers are important indexes to evaluate science research level of colleges and institutes and also important index to evaluate researchers. In this paper we calculated and analyzed the number of publications, cited number, and cited frequency of SCI papers in three military medical universities and one military medical research institution from 1997 to 2006, and put forward some opinions and suggestions.

Objective To study the clinical methods and effects of root cause analysis on the application of the Swiss cheese model in the psychiatric nursing adverse events. Methods Safety management groups were established to train nurses, use Swiss cheese model to analysis the root cause,formulate the corrective measures. The annual rates of incidence and reporting rate of adverse events were compared. Results One year after the root cause analysis on the application of the Swiss cheese model,the annual number of patients increased from 3 420 to 3 730,the cases of nursing adverse events reduced from 141 to 120,and the rate of nursing adverse events dropped from 4.12 percents to 3.21 percents (X2=4.16,P<0.05). The reporting cases of nursing adverse events increased from 65 to 102,and the reporting rate of nursing adverse events enhanced from 46.10 percents to 85.00 percents ( X2=42.57,P<0.01). Conclusions The use of root cause analysis on the application of the Swiss cheese model is the effective management model to analyze the nursing adverse events and to improve the nursing safety.

Lung cancer causes the highest number of cancer-related death in China. Complete surgical resection is currently the best treatment modality for lung cancer. However, only one third of patients with lung cancer can be identified as candidates for operation. The other two thirds are inoperable, because they have late disease with distant metastasis or locally advanced lung cancer involving neighboring organs. Recently introduction of the theory and technique of cardiovascular surgery into lung cancer surgery has made possible en bloc resection of the lung combined with part of the involved left atrium, aorta, superior vena cava, and pulmonary artery. It has made possible for the patients with locally advanced lung cancer, who were thought as surgical contraindication or incurable cases, to not only have complete resection of the tumor, but also achieved long term survival and good life quality without evidence of recurrence and distant metastasis of the cancer.This paper will provide a brief background at the progression of surgical theory and technology of locally advanced lung cancer in China. Besides, the indication, present methods, results of surgical management and multimodality treatment for locally advanced lung cancer, including extended resection and reconstruction of superior vena cava, left atrium, aorta and pulmonary artery will be presented. Finally, the perioperative management for the extended resection of locally advanced lung cancer will also be discussed.

Objective To investigate the molecular mechanism of CCl_(4) inducing fibrosis in hepatic stellate cells.Methods The expression of Transforming growth factor-?1(TGF-?1) at mRNA and protein level were detected by RT-PCR method and Western blot analysis.The proliferation and cell cycle distribution were detected with MTT method and flow cytometry.Results After treatment by(10 mmol/L) CCL_(4) for 24 hours,the mRNA and protein expression of TGF-?1 in CCl_(4) group sharply increased.In the meantime,the proliferation of CCl_(4) group cells was markedly increased.There were less G_(0)/G_(1) phase_() cells and more G_(2)/M phase cells in CCl_(4) group than those in control group.Conclusion Suitable CCl_(4) may increase the expression of TGF-?1 and the proliferation of hepatic stellate cells,which is one of mechanisms leading to hepatic fibrosis.

For the patients with chronic type-B hepatitis,interferon-? is still the main anti-viral medicine,but it cannot be used in hepatic cirrhosis patients during decompensative period.All commercially available ribonucleoside analogs or trialdrugs can only persistently inhibit virus replication,but not thoroughly clear virus,and have to be used for long-time.The combined therapy is still on study.The physicians should make scientific and individualized antiviral therapeutic regimen according to virus characteristics,the patient's response to anti-HBV therapy,tolerance and psychological health.

[Objective]To measure the contents of rhychophyline in uncaria,and its regularity of variety with decoction time.[Methods]RP-HPLC method was used.The chromatographic conditions were listed below:Hypersil-BDS C18 column(150mm?4.6mm.5?m),amobine phase composed of metranol-water(70∶30),a flow rate of 1ml /min and wave lengths was 254nm,column temperature was 25 ℃.[Results]In the range of 0.19?g ~0.95?g,the linear was very well between the content of rhychophyline and peak area.[Conclusion]The contents of rhychophyline in decoction reached the peak at 11.4min after uncaria was added in boiling water.

OBJECTIVE:To establish HPLC method for the content determination of paeoniflorin in wind-dispelling and itching-arresting oral liquid.METHODS:The determination was performed on Hypersil Gold C 18 column,the mobile phase consisted of methanol-1.5%H 3 PO 4 (35∶65)with flow rate at0.6ml/min and detection wavelength at230nm under room temperature.RESULTS:Peoniflorin was linear with peak area score when its sample size was within the range of0.0404?g～0.2020?g(r=0.9997),the average recovery was98.1%(RSD=0.99%).CONCLUSION:The method can be used to control the quality of wind-dispelling and itching-arresting oral liquid.