Objective To assess the correlation of intima media thickness (IMT) in two dimension ultrasound and hemodynamic parameters of Doppler with arteriosclerosis.Methods Eighteen male New Zealand white rabbits were fed by fat rich feed.At the beginning and the end of 4th week,8th week, 10th week, and 12th week, the parameters of systolic velocity(SV),diastolic velocity(DV),mean velocity(MV),pulsitive index(PI),resistent index(RI) and SV/DV in Doppler as well as maximum IMT and mean IMT in two dimensional ultrasound were obtained in all objects' abdominal aorta and their correlations with arteriosclerosis confirmed by partly animal dissection at the end of 4th week,8th week,10th week and 12th week were compared.Results Of all parameters,SV,SV/DV,PI and RI had significant positive correlation with arteriosclerosis (P 0.05 ).Conclusions Among above hemodynamics parameters of Doppler and morphologic change in two dimensional ultrasound,maximum IMT and mean IMT were found to be best correlative with arteriosclerosis.