Thyroid hormones (TH) play an imp or tant role in the development and maturity of the mammalian brain. Maternal TH de ficiency, even subclinical hypothyroidism, leads to poor neurodevelopment of the fetus. Screening of pregnant women for hypothyroidism is recommended. Identific ation of the TH-responsive genes in the developing brain and investigation on t heir functions are helpful to provide insights into the molecular mechanisms by which TH influence brain development.

Objective To evaluate the clinical value of dual-energy subtraction digital radiography in diagnosing the pulmonary nodulesand calification in nodules.Methods Using American GE Revolutln DR-XR systems,All 80 patients were examined by dual-energy.Tissus images、bone images and the original digital radiographic images were obtained.Dual-energy digital subtraction images were compared with the original digital radiographic images.Results Of 186 pulmonary nodules proved by CT,126(94 uncalified and 32 calified)were detected by tissues images and bone images and 109(83 uncalified and 26 calified)were detected by the original digital radiographic images.Conclusion Dual-energy subtraction imaging is superior to the original digital radiographic images in detection of pulmonary nodules and calification in a nodule.Dual-energy subtraction images can act as a complement for the original digital radiographic images.

Objective To investigate the correlation between the glycosylated hemoglobin (HbA1c) detection data and hemo‐rheological indicators in diabetes patients to provide reference basis for its treatment and prevention .Methods One hundred and forty‐two patients with typeⅡdiabetes mellitus(T2DM ) in the hospital were selected as the research subjects and divided into the A group(69 cases ,better control) and B group(73 cases ,poor control) according to the HbA1c detection results .Contemporaneous 70 healthy individuals undergoing physical examination were selected as the control (C group) .The detection results of HbA1c ,hemo‐rheology and biochemical indexes were performed the contrastive analysis .Results Except hematocrit and erythrocyte deformation index without statistical difference among 3 groups(P>0 .05) ,the other hemorheologic indicators had statistical differences among 3 groups(P<0 .05) .No matter the HbA1c level in T2DM patients ,the hemorheological indexes ,triglyceride and total cholesterol were higher than those in the healthy people ,When the HbA1c leve was poorly controlled ,the increase degresss of various indexes were more significant .Conclusion The abnormality of hemorheology indices exist in most of the patients with diabetes mellitus .It is recommended that clinic should monitor the HbA1c level for long term and strictly observe the change of hemorheology indexes to guide the clinical treatment for reaching the effects of early vascular protection and prevention of diabetic complications .

Adolescent ; Adult ; Diagnosis, Differential ; Humans ; Male ; Mesothelioma ; pathology ; surgery ; Peritoneal Neoplasms ; pathology ; surgery ; Peritoneum ; pathology ; surgery

Objective To investigate the clinical features and prognosis of elderly patients with acute panereatitis.Methods One hundred and twelve elderly patients with acute pancreatitis were included in our study.The clinical features and prognosis were compared with those of the 120 non -aged patients with acute pancreatitis during the same period.Results Cholecystolithiasis was the most common etiology of acute pancreatitis in both groups[81 cases(66.3%) in aged group,70 cases (58.3%) in non-aged group].Abdominal pain was the most common symptom in both groups, followed by fever.Two elderly cases were diagnosed only by autopsy because of mild abdominal pain and rapidly attack of shock.There were 31 cases with severe pancreatitis in aged group and 14 in non -aged group (P

Medical postgraduates are the future core force of clinical diagnosis and treatment,scientific research,education and sanitary administration.Therefore,to cultivate qualified professionals,the key of contemporary medical postgraduate education is to pay more attention to comprehensive quality training in order to make students adapt to the continuous development of society and medical model.The First Clinical College in Wuhan University has implemented the hospital administration internship in combination with social needs and explored the education model of contemporary medical students with comprehensive quality.

A metabonomics method based on gas chromatography_mass spectrometry ( GC_MS) was developed for detecting the significant differences of root exudates of the Cd hyperaccumulator Sedum alfredii under different treatments and study the effect mechanism of S. alfredii tolerating or accumulating the heavy metal Cd. The root exudates were collected after treatment for 4 and 8 days with 0 and 40μmol/L Cd. The collected solution was lyophilized and dissolved with methanol, and after derivatization with methoxyamine hydrochloride and N_methyl_N_trifluoroacetamide, the samples were analyzed by GC_MS. Principal component analysis ( PCA) and orthogonal partial least_squares discrimination analysis ( OPLS_DA) were carried out for pattern recognition and a clear separation among the different treatments was achieved. Twelve compounds which caused the separation among the different treatments were found and identified. With the change of treatments, the relative amount of these 12 compounds revealed different trends, which indicated that the Cd hyperaccumulator S. alfredii could adjust the secretion of root exudates to tolerate or accumulate the heavy metal Cd.

Objective To observe the effect of tongue-drawing at lateral position in nasogastric intubation for senile patients with conscious disorders. Methods One hundred senile patients with conscious disorders were randomly divided into observation group and control group with 50 cases in each group. The patients in the control group were given routine nasogastric intubation while those in the observation group were given nasogastric intubation by tongue drawing at the lateral position. The two groups were compared in terms of success rate of intubation, the rate of adverse reactions and intubation effects. Result Compared with the control group, the observation group showed significantly higher in one-time intubation success rate , comfort rate and lower rate of adverse reaction (all P<0.01). Conclusions The nasogastric intubation by tongue-drawing at lateral position is superior to the routine intubation. It can improve the success rate of one-time intubation, decrease the rate of adverse reactions and relieve the pains of patients.

Objective To analyze the main clinical manifestations of intestinal lipoma and discuss the treatment of intestinal lipoma.Methods The clinical data of 19 patients with intestinal lipoma treated in our hospital in recent 15 years were analyzed retrospectively.CT,ultrasonography,and colonoscopy were used in diagnosis.Local intestinal resection by laparoscopy and laparotomy were employde.Results Intestinal lipoma presented with a variety of symptoms including intestinal bleeding,abdominal pain,anemia,intussusception,and bowel obstruction.In 17 of the intestinal lipoma patients,the main clinical manifestations were change of bowel habits,abdominal pain and bloody stool;13 of them had intestinal intussusception or obstruction,and two patients were asymptomatic.Sixteen patients underwent colonoscopy,and seven of them were correctly diagnosed.Seventeen patients received surgical resection and recovered.The diameter of mass was 3-6.5 cm.The pathologic exam showed submucosal lipoma in 12 cases,two cases showed ulcer formation with erosion,2 cases had intermural lipoma and one case had atypical lipoma with potential malignant transformation.Two asymptomatic patients diagnosed by colonoscopic biopsy werre only followed up at regular intervals.Conclusions Imaging diagnosis and colonoscopy are helpful in the preoperative diagnosis of intestinal lipoma.The method of treatment is based on the size of the tumor and presence or absence of pedicle.Endoscopic electrosection is often used for tumor mass less than 3 cm in diameter,otherwise local intestinal resection is the treatment of chocie.

Objective To evaluate the efficacy and safety of transdermal fentanyl path ( Durogesic, Xian Janssen) in patients with moderate to severe chronic non-cancer pain. Methods This open prospective study was approved by the Ethic committee of the hospital. After obtaining written informed consent we studied 46 ASA I - H patients (24 male, 22 female), aged 36-82 yr, suffering from moderate to severe chronic non-cancer pain. Durogesic 25 fxg/h was used. The patch and the site of application were changed every 3 days. The dose was adjusted to the level of pain reduction and side effects. The treatment was maintained for 2-4 weeks. The pain intensity measured using VAS, quality of life including appetite, mental state and sleep etc and side effects were recorded.Results Thirty-eight of the 46 patients completed the trial. The other 8 patients withdrew from the trial because of side effects. Durogesic significantly decreased pain (P