Objective: To assess the effect and safety of Qingwei Zhitong Pill(QZP) in treating duodenal ulcer with fire stagnation syndrome. Methods: A randomized, double-blinded double-mimic controlled trial was adopted. Sixty patients were treated with QZP, 60 with Sifang Wei tablet(SWT) and 40 served as the open treatment group. Results: In QZP group, the markedly effective rate evaluated by gastroscopy was 48.33%and the total effective rate was 76.67%; the markedly effective rate in relieving TCM syndromes was 73.33%and the total effective rate was 88.33%, the differences between the treatment group and the control group were significant (P

Objective To assess the therapeutic effect and safety of Longxiong Pingchuan Capsule(LPC) in treating bronchial asthma with sputum-stasis stagnation syndrome.Methods A randomized,double-blind positive controlled trial was adopted.Fifty two patients with bronchial asthma were treated with LPC,18 with Juanxiao Pill(JP).Results Compared with those before treatment,forced expiratory volume in one second(FEV1)and peak expiratory flow(PEF)increase obviously after treatment,difference being significant(P

Objective: To investigate the chemical constituents in the EtOAc fraction of the EtOH extract of Duchesnea indica Andr. Focke. Methods: Extraction was done with 95% EtOH. EtOAc fraction of the EtOH extract was isolated and purified by column chromatography using silica gel,RP-C18,Sephadex LH-20 and HPLC. The structures of the compounds were identified by their physico-chemical properties and spectral analysis. Results: Thirteen compounds were obtained from the EtOAc fraction of Duchesnea indica Andr. Focke and they were identified as euscaphic acid(1),arjunic acid(2),p-hydroxy cinnamic acid (3),apigenin(4),kaempferol(5),2α-hydroxy ursolic acid(6),2α-hydroxy oleanolic acid(7),tomentic acid(8),kaii-ichigeside F1 (9), potengriffioside A (10), rosamultin (11), kaempferol-3-O-β-D-glucoside (12), and isoquercitrin (13). Conclusion: The compounds 2-5,10, and 12 have been isolated from the genus of Duchesnea for the first time.

China ; Occupational Exposure ; prevention & control ; Risk Assessment ; Workplace

Objective: To assess the effect and safety of Qilong Capsule (QLC) in treating apoplexy involving the meridians (Qi-deficiency and blood-stasis syndrome ). Methods: A randomized , do uble-blinded double-dummy controlled trial was adopted. One hundred and two pati ents were treated with QLC, 101 with Xiaoshuan oral liquid (XOL ) and 200 served as the open treatment group. Results: The total effective rate in QLC group was 89.22% and symptomatic relieved rate 44.12%,showing t hat QLC was more effective than XOL（P＜0.01）.Conc lusion: QLC is effective for apoplexy involving the meridians and has no side an d toxic effects.

OBJECTIVE:To study the anti-inflammation effects of cacumen biotae water decoction on mice with auricle and ab-dominal inflammation. METHODS:Mice were randomized into a normal control group,a model group,a positive control group (0.25 g/L aspirin)and cacumen biotae high-dose,medium-dose and low-dose [1,0.5 and 0.25 g(medicinal materials)/L] groups, respectively marked as groups A,B,C,D,E and F,with 10 mice in each group. The mice were given drugs ig for 5 consecutive days. The models of auricle and abdominal inflammation were established for all groups except the normal control group. The con-tents of tumor necrosis factor α(TNF-α)and interleukin 1(IL-1)in the serum of mice with auricle inflammation were determined, and the swelling degree and swelling rate were calculated. The contents of TNF-α,IL-1 and acid-sensing ion channels 1a(ASIC1a) in the liver tissues of mice with abdominal inflammation and the concentration of proteins in the peritoneal lavage fluid(ΔA)there-of were detected. RESULTS:For mouse models of auricle inflammation,the contents of TNF-α and IL-1 in serum in group B were higher than in group A;the swelling degree and swelling rate and the contents of TNF-α and IL-1 in groups C,D,E and F were lower than in group B,and those of group E and F were higher than in group C. There were statistical differences(P<0.05). For mouse models of abdominal inflammation,the contents of TNF-α,IL-1 and ASIC1a in liver tissues and ΔA in group B were higher than in group A;the contents of TNF-α,IL-1 and ASIC1a as well as ΔA in groups C,D,E and F were lower than in group B. There were statistical differences(P<0.05). CONCLUSIONS:Cacumen biotae water decoction has anti-effect on acute auricle and abdominal inflammation by a mechanism which may be related to decreasing TNF-α,IL-1 and ASIC1a.

Objective To investigate the effect of Mahong decoction on serum VEGF and b-FGF of rat model bronchus asthma airway remolding. Method Forty SD rats randomly divided into four groups: blank group, asthma group, hormone group, Chinese medicine group. The asthmatic model was established by sensitization and challenge with ovalbumin, and the rats in the hormone group and Chinese medicine group conferred hormone and Chinese medicine before the challenge. ELISA was used to measure the level of serum VEGF and b-FGF. Results The serum VEGF and b-FGF in asthma group was higher than in other groups (P0.05). Conclusion Mahong decoction may control the level of serum VEGF and b-FGF of rat model of bronchus asthma airway remolding, which has the similar result with hormone.