1.Influences of astragulas(黄芪) on cerebroischemiareperfusion injury in gerbil
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care 2001;8(2):105-108
Objective:To study the influences of astragulas(黄芪) on cerebroischemiareperf usion injury in gerbils.Methods:The cerebral tissue delayed neuron death(DND) models of gerbil were established by means of ligating bilateral carotid arteries for 15 minutes then reperfusing for 48 hours and divided into shamoperation(SO) group,ischemiareperfusion(IR) group and astragulas injection (AI，黄芪注射液) group.The activities of Na ＋K＋ATPase and nitric oxide synthase(NOS) and the changes in contents of nitric oxide(NO) and excitat ory amino acid(EAA) in cerebral tissue were compared in different groups.Results:(1)In comparison with SO group the activities of Na＋K＋ATPase in IR and AI group were obviously decreased furthermore the decreases in IR group were mo re significant than those in AI group(all P<0.01).(2) The changes in co nten ts of lactic acid(LD) in cerebral tissue in all the groups had not statistically significance.(3)In comparison with SO group the activitis of NOS and the conten ts of NO in IR and AI group were reduced but the reductions in IR group were muc h more significant (P<0.05).(4)The contents of glutamic acid(Glu) in IR and AI group were higher than those in SO group and the increases in IR group w .05),meanwhile they in IR group were higher than those in AI group but the di fference was not significant.(6)Among all the groups the contents of γam inobutyric a cid (γGABA) and glycine(Gly) had not significant differences (all P>0.05).Conclusions:The mechanisms of astragulas on anticerebral ischemiareperfusion inj ury may be related to its preventing the reductions of activities of Na＋K ＋ATPase,NO S,and the decreases in synthetic volume of NO as well as its heightening the con tents of EAA after ischemia of brain tissue.
2.Effect of Tripterygium glycosides on thyroid function and auto-antibody in patients with Graves disease.
Ling TANG ; Zhi-qing LIANG ; Ke SU
Chinese Journal of Integrated Traditional and Western Medicine 2003;23(4):294-295
Adult
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Antithyroid Agents
;
therapeutic use
;
Autoantibodies
;
blood
;
Drugs, Chinese Herbal
;
therapeutic use
;
Female
;
Glycosides
;
therapeutic use
;
Graves Disease
;
drug therapy
;
immunology
;
Humans
;
Immunosuppressive Agents
;
therapeutic use
;
Male
;
Methimazole
;
therapeutic use
;
Middle Aged
;
Phytotherapy
;
Tripterygium
;
chemistry
5.Output strategies for publication of international papers on clinical trials of Chinese medicine.
Qing WANG ; Hong-Li MA ; Xiao-Ke WU
Chinese Journal of Integrated Traditional and Western Medicine 2014;34(9):1144-1148
Scientific research output of clinical trials in Chinese medicine (CM) is insufficient, but international papers hold an important scientific position in China. Based on the current situation, we analyzed the present publication situation of international medical papers in our country, and the feasibility and urgency of publishing international papers on clinical trials of CM. Finally, we proposed to use the PDCA (plan-do-check-action) cycle method to improve the quality control and management of CM clinical trials. Moreover, by combining our experience in relevant scientific research launched at our department, we expounded strategies for improving the quantity and quality of international papers in CM.
Bibliometrics
;
Clinical Trials as Topic
;
Medicine, Chinese Traditional
Result Analysis
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